A solid-state NMR method for characterization of pharmaceutical eutectics

Pharmaceutical eutectics are extremely useful for designing formulations, and currently, there are no techniques other than differential scanning calorimetry (DSC) that can confirm their formation. In this study, we demonstrate that 1 H fast magic angle spinning (MAS) solid-state NMR (SSNMR) experim...

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Bibliographic Details
Published inPhysical chemistry chemical physics : PCCP Vol. 26; no. 5; pp. 38 - 383
Main Authors Hareendran, Chaithanya, Shaligram, Parth S, Gonnade, Rajesh, Ajithkumar, T. G
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 31.01.2024
Subjects
Eutectics
Hydrogen bonding
NMR
Nuclear magnetic resonance
Pharmaceuticals
Solid state
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ISSN1463-9076
1463-9084
1463-9084
DOI10.1039/d3cp05615e

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Summary:Pharmaceutical eutectics are extremely useful for designing formulations, and currently, there are no techniques other than differential scanning calorimetry (DSC) that can confirm their formation. In this study, we demonstrate that 1 H fast magic angle spinning (MAS) solid-state NMR (SSNMR) experiments can confirm the formation of eutectics by detecting their intermolecular hydrogen bonding interactions. 2D 1 H- 1 H double quantum single quantum (DQSQ) correlation SSNMR experiment is demonstrated which can confirm the formation of pharmaceutical eutectics for which there are no techniques other than differential scanning calorimetry (DSC).
Bibliography:Electronic supplementary information (ESI) available. See DOI
https://doi.org/10.1039/d3cp05615e
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ISSN:1463-9076
1463-9084
1463-9084
DOI:10.1039/d3cp05615e