Influenza virus carrying an R292K mutation in the neuraminidase gene is not transmitted in ferrets

• Published in: Antiviral research Vol. 54; no. 2; pp. 99 - 111
• Main Authors: Herlocher, M.L, Carr, J, Ives, J, Elias, S, Truscon, R, Roberts, N, Monto, A.S
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.05.2002; Elsevier
• Subjects: Animals; Biological and medical sciences; Disease Models, Animal; Disease Transmission, Infectious; DNA, Viral; Ferret; Ferrets - virology; Fever; Fundamental and applied biological sciences. Psychology; Genetics; Influenza; Influenza A virus - enzymology; Influenza A virus - genetics; Influenza virus; Male; Microbiology; Mutation; Nasal Lavage Fluid - virology; Neuraminidase; Neuraminidase - genetics; Orthomyxoviridae Infections - transmission; Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains; Resistance; Sequence Analysis, DNA; Transmission; Viral Load; Virology; Resistance; Influenza; Ferret; Transmission; Neuraminidase; Fissipedia; Carnivora; Enzyme; Orthomyxoviridae; Influenzavirus; Host virus relation; Infection; Virus; Vertebrata; Mammalia; Glycosidases; Animal; Exo-α-sialidase; Viral disease; Hydrolases; Mutation; O-Glycosidases

A model of influenza transmission has been established in ferrets in which wild-type influenza infection in a donor ferret can be transmitted sequentially to other ferrets. We have studied the transmission in ferrets of a clinical isolate of A/Sydney/5/97 (H3N2) carrying the neuraminidase 292K mutat...