Modulating cancer mechanopathology to restore vascular function and enhance immunotherapy

• Published in: Cell reports. Medicine Vol. 5; no. 7; p. 101626
• Main Authors: Mpekris, Fotios, Panagi, Myrofora, Charalambous, Antonia, Voutouri, Chrysovalantis, Stylianopoulos, Triantafyllos
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 16.07.2024; Elsevier
• Subjects: Angiogenesis Inhibitors - therapeutic use; Animals; anti-angiogenic therapy; biomarkers; engineered bacteria; Humans; Immunotherapy - methods; Neoplasms - immunology; Neoplasms - pathology; Neoplasms - therapy; Neovascularization, Pathologic - pathology; precision oncology; Review; Tumor Microenvironment - drug effects; tumor normalization; precision oncology; anti-angiogenic therapy; engineered bacteria; tumor normalization; biomarkers

Solid tumor pathology, characterized by abnormalities in the tumor microenvironment (TME), challenges therapeutic effectiveness. Mechanical factors, including increased tumor stiffness and accumulation of intratumoral forces, can determine the success of cancer treatments, defining the tumor’s “mech...