MicroRNA-222 Promotes Invasion and Metastasis of Papillary Thyroid Cancer Through Targeting Protein Phosphatase 2 Regulatory Subunit B Alpha Expression

• Published in: Thyroid (New York, N.Y.) Vol. 28; no. 9; p. 1162
• Main Authors: Huang, Yanrui, Yu, Shuang, Cao, Siting, Yin, Yali, Hong, Shubin, Guan, Hongyu, Li, Yanbing, Xiao, Haipeng
• Format: Journal Article
• Language: English
• Published: United States 01.09.2018
• Subjects: Adult; Cell Line, Tumor; Cell Movement - physiology; Female; Gene Expression Regulation, Neoplastic; Humans; Male; MicroRNAs - genetics; MicroRNAs - metabolism; Middle Aged; Neoplasm Invasiveness - genetics; Neoplasm Invasiveness - pathology; Neoplasm Metastasis - genetics; Neoplasm Metastasis - pathology; Protein Phosphatase 2 - genetics; Protein Phosphatase 2 - metabolism; Thyroid Cancer, Papillary - genetics; Thyroid Cancer, Papillary - metabolism; Thyroid Cancer, Papillary - pathology; Thyroid Neoplasms - genetics; Thyroid Neoplasms - metabolism; Thyroid Neoplasms - pathology; AKT; PPP2R2A; invasion; papillary thyroid carcinoma; metastasis; miR-222

Increasing evidence indicates that microRNA dysfunction is involved in the pathogenesis and progression of cancer. MicroRNA-222 (miR-222) is upregulated in papillary thyroid carcinoma (PTC). However, the role of miR-222 in invasion and metastasis of PTC remains unknown. This study investigated the f...