Generalized estimating equation approach for analyzing the effects of metal-derived products on survival and hatching of zebrafish embryos

• Published in: Zebrafish Vol. 11; no. 4; p. 353
• Main Authors: Aparna, Chavare, Sanjeev, Sabnis, Ajit, Joshi, Shantaram, Kane, Jayesh, Bellare, Suresh, Akkihebbal K
• Format: Journal Article
• Language: English
• Published: United States 01.08.2014
• Subjects: Animals; Dose-Response Relationship, Drug; Embryo, Nonmammalian - drug effects; Embryo, Nonmammalian - embryology; Medicine, Ayurvedic; Metals - toxicity; Models, Theoretical; Time Factors; Toxicity Tests - methods; Zebrafish - embryology; Zebrafish - metabolism

Zebrafish embryos are widely used as a model to monitor the effect of chemicals on their survival and hatching at different time epochs. This experimental design generates longitudinal data in which the observations for a given subject are correlated and they are statistically independent across the...