Ketamine/Xylazine Anesthesia-Related Corneal Lesions in Rats With Surgically Implanted Venous Catheters Utilized in Nonclinical Intravenous Studies

• Published in: Toxicologic pathology Vol. 49; no. 3; p. 598
• Main Authors: Zwick, Laura S, Patrick, Daniel J, Knupp, Lauren C, Ramos, Meg F
• Format: Journal Article
• Language: English
• Published: United States 01.04.2021
• Subjects: rats; cornea; ketamine; xylazine; anesthesia

Nonclinical rodent studies with repeat slow intravenous dosing, such as safety assessments of anticancer therapeutics, often require the use of animals with surgically implanted catheters. Catheterization is a relatively short surgical procedure but requires use of anesthesia. Ketamine/xylazine inje...