Effects of induced hyperprolactinemia on in vitro fertilization cycles
To investigate the effect of induced endogenous hyperprolactinemia on the luteinization process, as expressed by the shift in the P:E2 ratio after hCG injection in IVF cycles. Serum PRL, E2, and P levels were measured in 49 IVF patients (leuprolide acetate and hMG protocol) on the day of hCG injecti...
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Published in | Fertility and sterility Vol. 63; no. 2; pp. 371 - 376 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
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New York, NY
Elsevier Inc
01.02.1995
Elsevier Science |
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Abstract | To investigate the effect of induced endogenous hyperprolactinemia on the luteinization process, as expressed by the shift in the P:E2 ratio after hCG injection in IVF cycles.
Serum PRL, E2, and P levels were measured in 49 IVF patients (leuprolide acetate and hMG protocol) on the day of hCG injection. Estradiol and P also were measured on the day after hCG. Serum P:E2 ratios were calculated for two groups of patients; group I (control): PRL ≤ 20 ng/mL (conversion factor to SI unit, 1.00); group II (hyperprolactinemia): PRL > 20 ng/mL. Estradiol and P also were measured in follicular fluid (FF) and the gamete performance was compared between groups.
Data analysis showed no significant differences in the mean ± SD serum peak E2(pg/mL; conversion factor to SI unit, 3.671) between groups: group I, 1,769 ± 843; group II, 2,333 ± 1,194; the mean FF E2 (pg/mL) group I, 351 ± 221; group II, 370 ± 186; or the mean FF P (ng/mL; conversion factor to SI unit, 3.180) group I, 8,357 ± 3,127; group II, 11,354 ± 12,888. No significant differences were found between groups in the P:E2 ratios on days 1 or 2: group I, 78 ± 48 and 209 ± 137; group II, 70 ± 47 and 224 ± 197, respectively. The magnitude of the P shift also showed no significant difference between the two groups; the mean ± SD shift in the P level was 2.9 ± 2.2 for group I, and 4.3 ±5.1 for group II. The serum PRL level had no effect on the fertilization rate (60% for group I and 70% for group II) or on the pregnancy rate (17% for group I and 23% for group II).
These findings suggest that mild endogenous hyperprolactinemia induced by ovarian stimulation does not affect granulosa cell luteinization and gamete performance in humans. |
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AbstractList | To investigate the effect of induced endogenous hyperprolactinemia on the luteinization process, as expressed by the shift in the P:E2 ratio after hCG injection in IVF cycles.
Serum PRL, E2, and P levels were measured in 49 IVF patients (leuprolide acetate and hMG protocol) on the day of hCG injection. Estradiol and P also were measured on the day after hCG. Serum P:E2 ratios were calculated for two groups of patients; group I (control): PRL < or = 20 ng/mL (conversion factor to SI unit, 1.00); group II (hyperprolactinemia): PRL > 20 ng/mL. Estradiol and P also were measured in follicular fluid (FF) and the gamete performance was compared between groups.
Data analysis showed no significant differences in the mean +/- SD serum peak E2 (pg/mL; conversion factor to SI unit, 3.671) between groups: group I, 1,769 +/- 843; group II, 2,333 +/- 1,194; the mean FF E2 (pg/mL) group I, 351 +/- 221; group II, 370 +/- 186; or the mean FF P (ng/mL; conversion factor to SI unit, 3.180) group I, 8,357 +/- 3,127; group II, 11,354 +/- 12,888. No significant differences were found between groups in the P:E2 ratios on days 1 or 2: group I, 78 +/- 48 and 209 +/- 137; group II, 70 +/- 47 and 224 +/- 197, respectively. The magnitude of the P shift also showed no significant difference between the two groups; the mean +/- SD shift in the P level was 2.9 +/- 2.2 for group I, and 4.3 +/- 5.1 for group II. The serum PRL level had no effect on the fertilization rate (60% for group I and 70% for group II) or on the pregnancy rate (17% for group I and 23% for group II).
These findings suggest that mild endogenous hyperprolactinemia induced by ovarian stimulation does not affect granulosa cell luteinization and gamete performance in humans. To investigate the effect of induced endogenous hyperprolactinemia on the luteinization process, as expressed by the shift in the P:E2 ratio after hCG injection in IVF cycles. Serum PRL, E2, and P levels were measured in 49 IVF patients (leuprolide acetate and hMG protocol) on the day of hCG injection. Estradiol and P also were measured on the day after hCG. Serum P:E2 ratios were calculated for two groups of patients; group I (control): PRL ≤ 20 ng/mL (conversion factor to SI unit, 1.00); group II (hyperprolactinemia): PRL > 20 ng/mL. Estradiol and P also were measured in follicular fluid (FF) and the gamete performance was compared between groups. Data analysis showed no significant differences in the mean ± SD serum peak E2(pg/mL; conversion factor to SI unit, 3.671) between groups: group I, 1,769 ± 843; group II, 2,333 ± 1,194; the mean FF E2 (pg/mL) group I, 351 ± 221; group II, 370 ± 186; or the mean FF P (ng/mL; conversion factor to SI unit, 3.180) group I, 8,357 ± 3,127; group II, 11,354 ± 12,888. No significant differences were found between groups in the P:E2 ratios on days 1 or 2: group I, 78 ± 48 and 209 ± 137; group II, 70 ± 47 and 224 ± 197, respectively. The magnitude of the P shift also showed no significant difference between the two groups; the mean ± SD shift in the P level was 2.9 ± 2.2 for group I, and 4.3 ±5.1 for group II. The serum PRL level had no effect on the fertilization rate (60% for group I and 70% for group II) or on the pregnancy rate (17% for group I and 23% for group II). These findings suggest that mild endogenous hyperprolactinemia induced by ovarian stimulation does not affect granulosa cell luteinization and gamete performance in humans. |
Author | Rawlins, Richard G. Piekos, Marek W. Radwanska, Ewa Binor, Zvi |
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Cites_doi | 10.1210/jcem-54-5-955 10.1210/jcem-59-4-727 10.1038/250653a0 10.1111/j.1365-2265.1974.tb01786.x 10.1210/endo-111-6-2001 10.1016/0002-9378(90)90920-3 10.1097/00003081-197803000-00010 10.1210/jcem-40-5-886 10.1210/jcem-60-3-501 10.1016/0002-9378(77)90735-9 10.1016/S0015-0282(16)47052-4 10.1016/S0015-0282(16)59768-4 10.1677/joe.0.0640555 10.1172/JCI107600 10.1210/jcem-56-3-474 10.1016/0039-128X(81)90067-2 10.1210/jcem-58-3-430 10.1210/jcem-54-6-1246 10.1016/S0015-0282(16)60975-5 |
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Copyright | 1995 American Society for Reproductive Medicine 1995 INIST-CNRS |
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Keywords | IVF fertilization Hyperprolactinemia ovulation induction pregnancy Human Agonist HMG Induction Peptide hormone Assisted procreation Gonadotropin RH Gonadotropin Luteinization Glycoprotein hormone Fecundation HCG In vitro Ovulation Placental hormone Hypothalamic hormone Endogenous Complication Female Biological effect Hormone releasing factor |
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prolactin in control of steroid secretion by the human graafian follicle publication-title: Nature doi: 10.1038/250653a0 contributor: fullname: McNatty – volume: 55 start-page: 8 year: 1980 ident: 10.1016/S0015-0282(16)57371-3_bb0055 article-title: Incidence of hyperprolactinemia during oral contraceptive therapy publication-title: Obstet Gynecol contributor: fullname: Reyniak – volume: 3 start-page: 105 year: 1974 ident: 10.1016/S0015-0282(16)57371-3_bb0010 article-title: Circulating levels of prolactin during the menstrual cycle publication-title: Clin Endocrinol (Oxf) doi: 10.1111/j.1365-2265.1974.tb01786.x contributor: fullname: McNeilly – volume: 111 start-page: 2001 year: 1982 ident: 10.1016/S0015-0282(16)57371-3_bb0045 article-title: Prolactin inhibition of LH stimulated androgen synthesis in ovarian interstitial cells cultures in defined medium: mechanism of action publication-title: Endocrinology doi: 10.1210/endo-111-6-2001 contributor: fullname: Magoffin – volume: 162 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publication-title: J Clin Endocrinol Metab doi: 10.1210/jcem-60-3-501 contributor: fullname: Richardson – volume: 129 start-page: 145 year: 1977 ident: 10.1016/S0015-0282(16)57371-3_bb0120 article-title: Plasma prolactin changes during the administration of human menopausal gonadotrophs in non-ovulatory women publication-title: Am J Obstet Gynecol doi: 10.1016/0002-9378(77)90735-9 contributor: fullname: Kemman – volume: 39 start-page: 594 year: 1983 ident: 10.1016/S0015-0282(16)57371-3_bb0030 article-title: Maturation and fertilization of morphologically immature human oocytes in a program of in vitro fertilization publication-title: Fertil Steril doi: 10.1016/S0015-0282(16)47052-4 contributor: fullname: Veeck – volume: 49 start-page: 432 year: 1988 ident: 10.1016/S0015-0282(16)57371-3_bb0075 article-title: Transient hyperprolactinemia during cycle stimulation: influence on the endocrine response and fertilization rate of human oocyte and effects of bromocriptine treatment publication-title: Fertil Steril doi: 10.1016/S0015-0282(16)59768-4 contributor: fullname: Reinthaller – volume: 73 start-page: 613 year: 1989 ident: 10.1016/S0015-0282(16)57371-3_bb0080 article-title: Luteal phase hyperprolactinemia during ovulation induction with human menopausal gonadotropins: incidence, recurrence and effect on pregnancy rates publication-title: Obstet Gynecol contributor: fullname: Tippet – volume: 29 start-page: 136 year: 1984 ident: 10.1016/S0015-0282(16)57371-3_bb0085 article-title: Transient hyperprolactinemia in human menopausal gonadotropin induction of ovulation publication-title: Int J Fertil contributor: fullname: Tang – volume: 64 start-page: 555 year: 1975 ident: 10.1016/S0015-0282(16)57371-3_bb0095 article-title: Changes in the concentration of pituitary hormones in the follicular fluid of human graafian follicles throughout the menstrual cycle publication-title: J Endocrinol doi: 10.1677/joe.0.0640555 contributor: fullname: McNatty – volume: 53 start-page: 652 year: 1974 ident: 10.1016/S0015-0282(16)57371-3_bb0050 article-title: Augmentation of prolactin secretion by estrogens in hypogonadal women publication-title: J Clin Invest doi: 10.1172/JCI107600 contributor: fullname: Yen – volume: 56 start-page: 474 year: 1983 ident: 10.1016/S0015-0282(16)57371-3_bb0025 article-title: Serum FSH, LH and PRL during the induction of ovulation with exogenous gonadotropin publication-title: J Clin Endocrinol Metab doi: 10.1210/jcem-56-3-474 contributor: fullname: Healy – volume: 38 start-page: 321 year: 1981 ident: 10.1016/S0015-0282(16)57371-3_bb0070 article-title: Hyperprolactinemia in monkeys: induction estrogen-progesterone synergy publication-title: Steroids doi: 10.1016/0039-128X(81)90067-2 contributor: fullname: Williams – volume: 58 start-page: 430 year: 1984 ident: 10.1016/S0015-0282(16)57371-3_bb0100 article-title: Gonadotropin and prolactin levels in follicular fluid of human ova successfully fertilized in vitro publication-title: J Clin Endocrinol Metab doi: 10.1210/jcem-58-3-430 contributor: fullname: Laufer – volume: 54 start-page: 1246 year: 1982 ident: 10.1016/S0015-0282(16)57371-3_bb0040 article-title: Prolactin directly inhibits basal as well as gonadotropin-stimulated secretion of progesterone and 17-β-estradiol in the human ovary publication-title: J Clin Endocrinol Metab doi: 10.1210/jcem-54-6-1246 contributor: fullname: Demura – volume: 52 start-page: 622 year: 1989 ident: 10.1016/S0015-0282(16)57371-3_bb0060 article-title: The incidence of transient hyperprolactinemia in gonadotropin stimulated cycles for in vitro fertilization and its effect on pregnancy outcome publication-title: Fertil Steril doi: 10.1016/S0015-0282(16)60975-5 contributor: fullname: Hofmann – volume: 12 start-page: 57 year: 1974 ident: 10.1016/S0015-0282(16)57371-3_bb0125 article-title: Prolactin and human reproduction publication-title: Br J Hosp Med contributor: fullname: McNeilly |
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Snippet | To investigate the effect of induced endogenous hyperprolactinemia on the luteinization process, as expressed by the shift in the P:E2 ratio after hCG... |
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SubjectTerms | Biological and medical sciences Birth control Chorionic Gonadotropin - therapeutic use Estradiol - blood Estradiol - metabolism Female fertilization Fertilization in Vitro Follicular Fluid - metabolism Gynecology. Andrology. Obstetrics Humans Hyperprolactinemia Hyperprolactinemia - blood Hyperprolactinemia - chemically induced IVF Leuprolide - therapeutic use Medical sciences Menotropins - adverse effects Menotropins - therapeutic use Ovulation Induction Pregnancy Progesterone - blood Progesterone - metabolism Sterility. Assisted procreation |
Title | Effects of induced hyperprolactinemia on in vitro fertilization cycles |
URI | https://dx.doi.org/10.1016/S0015-0282(16)57371-3 https://www.ncbi.nlm.nih.gov/pubmed/7843446 |
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