Effects of induced hyperprolactinemia on in vitro fertilization cycles
To investigate the effect of induced endogenous hyperprolactinemia on the luteinization process, as expressed by the shift in the P:E2 ratio after hCG injection in IVF cycles. Serum PRL, E2, and P levels were measured in 49 IVF patients (leuprolide acetate and hMG protocol) on the day of hCG injecti...
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Published in | Fertility and sterility Vol. 63; no. 2; pp. 371 - 376 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
New York, NY
Elsevier Inc
01.02.1995
Elsevier Science |
Subjects | |
Online Access | Get full text |
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Summary: | To investigate the effect of induced endogenous hyperprolactinemia on the luteinization process, as expressed by the shift in the P:E2 ratio after hCG injection in IVF cycles.
Serum PRL, E2, and P levels were measured in 49 IVF patients (leuprolide acetate and hMG protocol) on the day of hCG injection. Estradiol and P also were measured on the day after hCG. Serum P:E2 ratios were calculated for two groups of patients; group I (control): PRL ≤ 20 ng/mL (conversion factor to SI unit, 1.00); group II (hyperprolactinemia): PRL > 20 ng/mL. Estradiol and P also were measured in follicular fluid (FF) and the gamete performance was compared between groups.
Data analysis showed no significant differences in the mean ± SD serum peak E2(pg/mL; conversion factor to SI unit, 3.671) between groups: group I, 1,769 ± 843; group II, 2,333 ± 1,194; the mean FF E2 (pg/mL) group I, 351 ± 221; group II, 370 ± 186; or the mean FF P (ng/mL; conversion factor to SI unit, 3.180) group I, 8,357 ± 3,127; group II, 11,354 ± 12,888. No significant differences were found between groups in the P:E2 ratios on days 1 or 2: group I, 78 ± 48 and 209 ± 137; group II, 70 ± 47 and 224 ± 197, respectively. The magnitude of the P shift also showed no significant difference between the two groups; the mean ± SD shift in the P level was 2.9 ± 2.2 for group I, and 4.3 ±5.1 for group II. The serum PRL level had no effect on the fertilization rate (60% for group I and 70% for group II) or on the pregnancy rate (17% for group I and 23% for group II).
These findings suggest that mild endogenous hyperprolactinemia induced by ovarian stimulation does not affect granulosa cell luteinization and gamete performance in humans. |
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ISSN: | 0015-0282 1556-5653 |
DOI: | 10.1016/S0015-0282(16)57371-3 |