MicroRNA-191 regulates endometrial cancer cell growth via TET1-mediated epigenetic modulation of APC

• Published in: Journal of biochemistry (Tokyo) Vol. 168; no. 1; pp. 7 - 14
• Main Authors: Yang, Chiujung, Ota-Kurogi, Natsuki, Ikeda, Kazuhiro, Okumura, Toshiyuki, Horie-Inoue, Kuniko, Takeda, Satoru, Inoue, Satoshi
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.07.2020
• Subjects: Adenomatous Polyposis Coli Protein - genetics; Adenomatous Polyposis Coli Protein - metabolism; Biomarkers, Tumor - genetics; Cell Line, Tumor; Cell Proliferation; DNA Methylation; Down-Regulation; Endometrial Neoplasms - genetics; Endometrial Neoplasms - metabolism; Endometrial Neoplasms - pathology; Female; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs - genetics; Mixed Function Oxygenases - genetics; Mixed Function Oxygenases - metabolism; Promoter Regions, Genetic; Proto-Oncogene Proteins - genetics; Proto-Oncogene Proteins - metabolism; endometrial cancer; miRNA-191; epigenetic regulation; ten–eleven translocation 1; 5-hydroxymethylcytosine

Abstract Endometrial cancer (EC) is a common gynecological malignancy with relatively favourable prognosis, although alternative diagnostic and therapeutic options remain to be explored for advanced disease. Recent studies enabled to apply microRNAs (miRs) to clinical cancer management as promising...