Pristine gelatin incorporation as a strategy to enhance the biofunctionality of poly(vinyl alcohol)-based hydrogels for tissue engineering applications

• Published in: Biomaterials science Vol. 12; no. 1; pp. 134 - 15
• Main Authors: Longoni, Alessia, Major, Gretel S, Jiang, Shaoyuan, Farrugia, Brooke L, Kieser, David C, Woodfield, Tim B. F, Rnjak-Kovacina, Jelena, Lim, Khoon S
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 19.12.2023
• Subjects: Animals; Biocompatible Materials - chemistry; Biocompatible Materials - pharmacology; Biomedical materials; Blood vessels; Chemical properties; Constraining; Controlled release; Endothelial cells; Ethanol; Gelatin; Gelatin - chemistry; Growth factors; Hydrogels; Hydrogels - chemistry; Infiltration; Mice; Physical properties; Polymers - chemistry; Polyvinyl alcohol; Polyvinyl Alcohol - chemistry; Surgical implants; Tissue Engineering; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A

Synthetic polymers, such as poly(vinyl alcohol) (PVA), are popular biomaterials for the fabrication of hydrogels for tissue engineering and regenerative medicine (TERM) applications, as they provide excellent control over the physico-chemical properties of the hydrogel. However, their bioinert natur...