Pristine gelatin incorporation as a strategy to enhance the biofunctionality of poly(vinyl alcohol)-based hydrogels for tissue engineering applications
Synthetic polymers, such as poly(vinyl alcohol) (PVA), are popular biomaterials for the fabrication of hydrogels for tissue engineering and regenerative medicine (TERM) applications, as they provide excellent control over the physico-chemical properties of the hydrogel. However, their bioinert natur...
Saved in:
Published in | Biomaterials science Vol. 12; no. 1; pp. 134 - 15 |
---|---|
Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Royal Society of Chemistry
19.12.2023
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Synthetic polymers, such as poly(vinyl alcohol) (PVA), are popular biomaterials for the fabrication of hydrogels for tissue engineering and regenerative medicine (TERM) applications, as they provide excellent control over the physico-chemical properties of the hydrogel. However, their bioinert nature is known to limit cell-biomaterial interactions by hindering cell infiltration, blood vessel recruitment and potentially limiting their integration with the host tissue. Efforts in the field have therefore focused on increasing the biofunctionality of synthetic hydrogels, without limiting the advantages associated with their tailorability and controlled release capacity. The aim of this study was to investigate the suitability of pristine gelatin to enhance the biofunctionality of tyraminated PVA (PVA-Tyr) hydrogels, by promoting cell infiltration and host blood vessel recruitment for TERM applications. Pure PVA-Tyr hydrogels and PVA-Tyr hydrogels incorporated with vascular endothelial growth factor (VEGF), a well-known pro-angiogenic stimulus, were used for comparison. Incorporating increasing concentrations of VEGF (0.01-10 μg mL
−1
) or gelatin (0.01-5 wt%) did not influence the physical properties of PVA-Tyr hydrogels. However, their presence within the polymer network (>0.1 μg mL
−1
VEGF and >0.1 wt% gelatin) promoted endothelial cell interactions with the hydrogels. The covalent binding of unmodified gelatin or VEGF to the PVA-Tyr network did not hamper their inherent bioactivity, as they both promoted angiogenesis in a chick chorioallantoic membrane (CAM) assay, performing comparably with the unbound VEGF control. When the PVA-Tyr hydrogels were implanted subcutaneously in mice, it was observed that cell infiltration into the hydrogels was possible in the absence of gelatin or VEGF at 1- or 3-weeks post-implantation, highlighting a clear difference between
in vitro
an
in vivo
cell-biomaterial interaction. Nevertheless, the presence of gelatin or VEGF was necessary to enhance blood vessel recruitment and infiltration, although no significant difference was observed between these two biological molecules. Overall, this study highlights the potential of gelatin as a standalone pro-angiogenic cue to enhance biofunctionality of synthetic hydrogels and provides promise for their use in a variety of TERM applications.
In this study, we investigated the suitability of pristine gelatin to enhance the biofunctionality of tyraminated PVA hydrogels, by promoting cell infiltration and host blood vessel recruitment
in vitro
and
in vivo
for tissue engineering applications. |
---|---|
AbstractList | Synthetic polymers, such as poly(vinyl alcohol) (PVA), are popular biomaterials for the fabrication of hydrogels for tissue engineering and regenerative medicine (TERM) applications, as they provide excellent control over the physico-chemical properties of the hydrogel. However, their bioinert nature is known to limit cell-biomaterial interactions by hindering cell infiltration, blood vessel recruitment and potentially limiting their integration with the host tissue. Efforts in the field have therefore focused on increasing the biofunctionality of synthetic hydrogels, without limiting the advantages associated with their tailorability and controlled release capacity. The aim of this study was to investigate the suitability of pristine gelatin to enhance the biofunctionality of tyraminated PVA (PVA-Tyr) hydrogels, by promoting cell infiltration and host blood vessel recruitment for TERM applications. Pure PVA-Tyr hydrogels and PVA-Tyr hydrogels incorporated with vascular endothelial growth factor (VEGF), a well-known pro-angiogenic stimulus, were used for comparison. Incorporating increasing concentrations of VEGF (0.01–10 μg mL−1) or gelatin (0.01–5 wt%) did not influence the physical properties of PVA-Tyr hydrogels. However, their presence within the polymer network (>0.1 μg mL−1 VEGF and >0.1 wt% gelatin) promoted endothelial cell interactions with the hydrogels. The covalent binding of unmodified gelatin or VEGF to the PVA-Tyr network did not hamper their inherent bioactivity, as they both promoted angiogenesis in a chick chorioallantoic membrane (CAM) assay, performing comparably with the unbound VEGF control. When the PVA-Tyr hydrogels were implanted subcutaneously in mice, it was observed that cell infiltration into the hydrogels was possible in the absence of gelatin or VEGF at 1- or 3-weeks post-implantation, highlighting a clear difference between in vitro an in vivo cell-biomaterial interaction. Nevertheless, the presence of gelatin or VEGF was necessary to enhance blood vessel recruitment and infiltration, although no significant difference was observed between these two biological molecules. Overall, this study highlights the potential of gelatin as a standalone pro-angiogenic cue to enhance biofunctionality of synthetic hydrogels and provides promise for their use in a variety of TERM applications. Synthetic polymers, such as poly(vinyl alcohol) (PVA), are popular biomaterials for the fabrication of hydrogels for tissue engineering and regenerative medicine (TERM) applications, as they provide excellent control over the physico-chemical properties of the hydrogel. However, their bioinert nature is known to limit cell-biomaterial interactions by hindering cell infiltration, blood vessel recruitment and potentially limiting their integration with the host tissue. Efforts in the field have therefore focused on increasing the biofunctionality of synthetic hydrogels, without limiting the advantages associated with their tailorability and controlled release capacity. The aim of this study was to investigate the suitability of pristine gelatin to enhance the biofunctionality of tyraminated PVA (PVA-Tyr) hydrogels, by promoting cell infiltration and host blood vessel recruitment for TERM applications. Pure PVA-Tyr hydrogels and PVA-Tyr hydrogels incorporated with vascular endothelial growth factor (VEGF), a well-known pro-angiogenic stimulus, were used for comparison. Incorporating increasing concentrations of VEGF (0.01–10 μg mL −1 ) or gelatin (0.01–5 wt%) did not influence the physical properties of PVA-Tyr hydrogels. However, their presence within the polymer network (>0.1 μg mL −1 VEGF and >0.1 wt% gelatin) promoted endothelial cell interactions with the hydrogels. The covalent binding of unmodified gelatin or VEGF to the PVA-Tyr network did not hamper their inherent bioactivity, as they both promoted angiogenesis in a chick chorioallantoic membrane (CAM) assay, performing comparably with the unbound VEGF control. When the PVA-Tyr hydrogels were implanted subcutaneously in mice, it was observed that cell infiltration into the hydrogels was possible in the absence of gelatin or VEGF at 1- or 3-weeks post-implantation, highlighting a clear difference between in vitro an in vivo cell-biomaterial interaction. Nevertheless, the presence of gelatin or VEGF was necessary to enhance blood vessel recruitment and infiltration, although no significant difference was observed between these two biological molecules. Overall, this study highlights the potential of gelatin as a standalone pro-angiogenic cue to enhance biofunctionality of synthetic hydrogels and provides promise for their use in a variety of TERM applications. Synthetic polymers, such as poly(vinyl alcohol) (PVA), are popular biomaterials for the fabrication of hydrogels for tissue engineering and regenerative medicine (TERM) applications, as they provide excellent control over the physico-chemical properties of the hydrogel. However, their bioinert nature is known to limit cell-biomaterial interactions by hindering cell infiltration, blood vessel recruitment and potentially limiting their integration with the host tissue. Efforts in the field have therefore focused on increasing the biofunctionality of synthetic hydrogels, without limiting the advantages associated with their tailorability and controlled release capacity. The aim of this study was to investigate the suitability of pristine gelatin to enhance the biofunctionality of tyraminated PVA (PVA-Tyr) hydrogels, by promoting cell infiltration and host blood vessel recruitment for TERM applications. Pure PVA-Tyr hydrogels and PVA-Tyr hydrogels incorporated with vascular endothelial growth factor (VEGF), a well-known pro-angiogenic stimulus, were used for comparison. Incorporating increasing concentrations of VEGF (0.01-10 μg mL-1) or gelatin (0.01-5 wt%) did not influence the physical properties of PVA-Tyr hydrogels. However, their presence within the polymer network (>0.1 μg mL-1 VEGF and >0.1 wt% gelatin) promoted endothelial cell interactions with the hydrogels. The covalent binding of unmodified gelatin or VEGF to the PVA-Tyr network did not hamper their inherent bioactivity, as they both promoted angiogenesis in a chick chorioallantoic membrane (CAM) assay, performing comparably with the unbound VEGF control. When the PVA-Tyr hydrogels were implanted subcutaneously in mice, it was observed that cell infiltration into the hydrogels was possible in the absence of gelatin or VEGF at 1- or 3-weeks post-implantation, highlighting a clear difference between in vitro an in vivo cell-biomaterial interaction. Nevertheless, the presence of gelatin or VEGF was necessary to enhance blood vessel recruitment and infiltration, although no significant difference was observed between these two biological molecules. Overall, this study highlights the potential of gelatin as a standalone pro-angiogenic cue to enhance biofunctionality of synthetic hydrogels and provides promise for their use in a variety of TERM applications. Synthetic polymers, such as poly(vinyl alcohol) (PVA), are popular biomaterials for the fabrication of hydrogels for tissue engineering and regenerative medicine (TERM) applications, as they provide excellent control over the physico-chemical properties of the hydrogel. However, their bioinert nature is known to limit cell-biomaterial interactions by hindering cell infiltration, blood vessel recruitment and potentially limiting their integration with the host tissue. Efforts in the field have therefore focused on increasing the biofunctionality of synthetic hydrogels, without limiting the advantages associated with their tailorability and controlled release capacity. The aim of this study was to investigate the suitability of pristine gelatin to enhance the biofunctionality of tyraminated PVA (PVA-Tyr) hydrogels, by promoting cell infiltration and host blood vessel recruitment for TERM applications. Pure PVA-Tyr hydrogels and PVA-Tyr hydrogels incorporated with vascular endothelial growth factor (VEGF), a well-known pro-angiogenic stimulus, were used for comparison. Incorporating increasing concentrations of VEGF (0.01-10 μg mL −1 ) or gelatin (0.01-5 wt%) did not influence the physical properties of PVA-Tyr hydrogels. However, their presence within the polymer network (>0.1 μg mL −1 VEGF and >0.1 wt% gelatin) promoted endothelial cell interactions with the hydrogels. The covalent binding of unmodified gelatin or VEGF to the PVA-Tyr network did not hamper their inherent bioactivity, as they both promoted angiogenesis in a chick chorioallantoic membrane (CAM) assay, performing comparably with the unbound VEGF control. When the PVA-Tyr hydrogels were implanted subcutaneously in mice, it was observed that cell infiltration into the hydrogels was possible in the absence of gelatin or VEGF at 1- or 3-weeks post-implantation, highlighting a clear difference between in vitro an in vivo cell-biomaterial interaction. Nevertheless, the presence of gelatin or VEGF was necessary to enhance blood vessel recruitment and infiltration, although no significant difference was observed between these two biological molecules. Overall, this study highlights the potential of gelatin as a standalone pro-angiogenic cue to enhance biofunctionality of synthetic hydrogels and provides promise for their use in a variety of TERM applications. In this study, we investigated the suitability of pristine gelatin to enhance the biofunctionality of tyraminated PVA hydrogels, by promoting cell infiltration and host blood vessel recruitment in vitro and in vivo for tissue engineering applications. Synthetic polymers, such as poly(vinyl alcohol) (PVA), are popular biomaterials for the fabrication of hydrogels for tissue engineering and regenerative medicine (TERM) applications, as they provide excellent control over the physico-chemical properties of the hydrogel. However, their bioinert nature is known to limit cell-biomaterial interactions by hindering cell infiltration, blood vessel recruitment and potentially limiting their integration with the host tissue. Efforts in the field have therefore focused on increasing the biofunctionality of synthetic hydrogels, without limiting the advantages associated with their tailorability and controlled release capacity. The aim of this study was to investigate the suitability of pristine gelatin to enhance the biofunctionality of tyraminated PVA (PVA-Tyr) hydrogels, by promoting cell infiltration and host blood vessel recruitment for TERM applications. Pure PVA-Tyr hydrogels and PVA-Tyr hydrogels incorporated with vascular endothelial growth factor (VEGF), a well-known pro-angiogenic stimulus, were used for comparison. Incorporating increasing concentrations of VEGF (0.01-10 μg mL ) or gelatin (0.01-5 wt%) did not influence the physical properties of PVA-Tyr hydrogels. However, their presence within the polymer network (>0.1 μg mL VEGF and >0.1 wt% gelatin) promoted endothelial cell interactions with the hydrogels. The covalent binding of unmodified gelatin or VEGF to the PVA-Tyr network did not hamper their inherent bioactivity, as they both promoted angiogenesis in a chick chorioallantoic membrane (CAM) assay, performing comparably with the unbound VEGF control. When the PVA-Tyr hydrogels were implanted subcutaneously in mice, it was observed that cell infiltration into the hydrogels was possible in the absence of gelatin or VEGF at 1- or 3-weeks post-implantation, highlighting a clear difference between an cell-biomaterial interaction. Nevertheless, the presence of gelatin or VEGF was necessary to enhance blood vessel recruitment and infiltration, although no significant difference was observed between these two biological molecules. Overall, this study highlights the potential of gelatin as a standalone pro-angiogenic cue to enhance biofunctionality of synthetic hydrogels and provides promise for their use in a variety of TERM applications. |
Author | Farrugia, Brooke L Lim, Khoon S Major, Gretel S Woodfield, Tim B. F Longoni, Alessia Kieser, David C Rnjak-Kovacina, Jelena Jiang, Shaoyuan |
AuthorAffiliation | UNSW Sydney University of Otago Christchurch Light-Activated Biomaterials Group Department of Orthopaedic Surgery and Musculoskeletal Medicine Graduate School of Biomedical Engineering University of Melbourne School of Biomedical Engineering School of Medical Sciences University of Sydney |
AuthorAffiliation_xml | – sequence: 0 name: University of Otago Christchurch – sequence: 0 name: School of Biomedical Engineering – sequence: 0 name: University of Melbourne – sequence: 0 name: Department of Orthopaedic Surgery and Musculoskeletal Medicine – sequence: 0 name: Light-Activated Biomaterials Group – sequence: 0 name: Graduate School of Biomedical Engineering – sequence: 0 name: UNSW Sydney – sequence: 0 name: School of Medical Sciences – sequence: 0 name: University of Sydney |
Author_xml | – sequence: 1 givenname: Alessia surname: Longoni fullname: Longoni, Alessia – sequence: 2 givenname: Gretel S surname: Major fullname: Major, Gretel S – sequence: 3 givenname: Shaoyuan surname: Jiang fullname: Jiang, Shaoyuan – sequence: 4 givenname: Brooke L surname: Farrugia fullname: Farrugia, Brooke L – sequence: 5 givenname: David C surname: Kieser fullname: Kieser, David C – sequence: 6 givenname: Tim B. F surname: Woodfield fullname: Woodfield, Tim B. F – sequence: 7 givenname: Jelena surname: Rnjak-Kovacina fullname: Rnjak-Kovacina, Jelena – sequence: 8 givenname: Khoon S surname: Lim fullname: Lim, Khoon S |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37933486$$D View this record in MEDLINE/PubMed |
BookMark | eNpdkU9v1DAQxS1URNulF-4gS1wKUsCO88c-QktbRBEc4BxNnPGui9dO7QQpn6RfF7dbFgkfxjOan97T6B2TAx88EvKCs3ecCfV-EP2Wcd6Wv56Qo5JVbVHJSh3se8EOyUlKNyy_tlWs4c_IoWiVEJVsjsjd92jTZD3SNTrIDbVehziGmIfgKSQKNE15wvVCp0DRb8BrpNMGaW-Dmb2-B8HZaaHB0DG45fS39Yuj4HTYBPem6CHhQDfLEEN2SdSESCeb0oxZbp3NMVq_pjCOzuoH3_ScPDXgEp48_ivy8-LTj7Or4vrb5eezD9eFFqKdClCDbsqqx1oxANkwpo0GKQE4IJRay7LBesinD1LXJedGKKW0qUCBactWrMjpTneM4XbGNHVbmzQ6Bx7DnLpSykYJVeeyIq__Q2_CHPPlmVJMiLqueZWptztKx5BSRNON0W4hLh1n3X1i3bn4-PUhsS8ZfvUoOfdbHPbo33wy8HIHxKT323-Riz9njaA0 |
CitedBy_id | crossref_primary_10_1002_adhm_202401195 crossref_primary_10_3390_ma17061286 crossref_primary_10_1016_j_cej_2024_150234 crossref_primary_10_1002_mabi_202400049 |
Cites_doi | 10.1016/j.msec.2021.112544 10.1016/j.biomaterials.2013.06.005 10.1016/j.actbio.2021.08.038 10.1039/D1MA00092F 10.1007/s10856-016-5763-9 10.1007/s10439-018-02171-3 10.1016/j.matdes.2021.109652 10.1074/jbc.M609323200 10.1089/ten.tea.2008.0146 10.1073/pnas.1404605111 10.1089/ten.teb.2019.0256 10.1186/s13287-022-03009-5 10.1002/mabi.201000505 10.1039/D0BM00603C 10.22203/eCM.v038a08 10.1016/j.actbio.2017.06.012 10.1007/s13233-022-0027-7 10.1016/j.biomaterials.2013.04.050 10.1021/acs.chemrev.1c00798 10.1038/am.2017.171 10.1016/j.biomaterials.2012.07.057 10.1016/j.actbio.2016.09.006 10.1021/acsabm.9b00275 10.1039/C5TB00939A 10.1021/acsbiomaterials.9b01624 10.3389/fbioe.2020.00188 10.1016/j.actbio.2017.02.044 10.3389/fbioe.2022.849831 10.2147/IJN.S18753 10.1016/j.mvr.2020.104026 10.1016/j.biomaterials.2005.05.036 10.1016/j.actbio.2020.03.005 10.1002/adhm.202100312 10.1016/0741-5214(93)90115-3 10.1016/j.yexcr.2021.112716 10.1016/j.ijpharm.2019.02.043 10.1002/jbm.a.35510 10.1016/j.actbio.2019.07.035 10.1002/advs.202000900 10.1016/j.matdes.2022.110663 10.1002/term.292 10.3390/molecules26040873 10.1016/j.ijbiomac.2022.08.025 10.1002/adhm.202102818 10.1371/journal.pone.0058897 10.1016/j.colsurfb.2019.110756 10.1172/JCI18420 10.1016/j.actbio.2015.08.044 10.1109/TSMC.1979.4310076 10.1096/fj.02-0691fje 10.1038/gt.2011.66 10.1016/j.biomaterials.2020.120104 10.1007/s13346-013-0142-2 10.1016/S0142-9612(00)00196-4 10.1021/acs.bioconjchem.0c00270 10.1016/j.tibtech.2018.01.008 10.1002/sctm.19-0319 10.1371/journal.pbio.3000410 10.1002/term.2957 10.1002/adfm.202210521 10.1016/j.actbio.2012.05.019 10.1021/bm7007907 10.1042/bj0840468 10.1016/j.biomaterials.2018.10.039 10.1021/acsbiomaterials.9b01220 10.1007/s10529-015-1907-0 10.1161/01.CIR.94.5.1074 10.1021/acsabm.0c01648 10.1016/j.biomaterials.2007.08.040 10.1002/adhm.201600058 10.1016/j.actbio.2015.02.024 10.3390/polym12030570 10.1016/j.actbio.2020.01.041 10.1088/2516-1091/abc947 10.1016/j.eurpolymj.2021.110974 10.1016/j.heliyon.2018.e00770 10.1016/j.biomaterials.2011.06.027 10.1016/j.actbio.2014.11.002 10.1038/s41598-017-17204-5 10.1016/j.ijbiomac.2014.09.058 |
ContentType | Journal Article |
Copyright | Copyright Royal Society of Chemistry 2024 |
Copyright_xml | – notice: Copyright Royal Society of Chemistry 2024 |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7SR 8BQ 8FD JG9 7X8 |
DOI | 10.1039/d3bm01172k |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Engineered Materials Abstracts METADEX Technology Research Database Materials Research Database MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Materials Research Database Engineered Materials Abstracts Technology Research Database METADEX MEDLINE - Academic |
DatabaseTitleList | Materials Research Database CrossRef MEDLINE - Academic MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Engineering |
EISSN | 2047-4849 |
EndPage | 15 |
ExternalDocumentID | 10_1039_D3BM01172K 37933486 d3bm01172k |
Genre | Journal Article |
GroupedDBID | -JG 0-7 0R~ 4.4 53G 705 AAEMU AAHBH AAIWI AAJAE AANOJ AARTK AAWGC AAXHV ABASK ABDVN ABEMK ABJNI ABPDG ABRYZ ABXOH ACGFS ACIWK ACLDK ADMRA ADSRN AEFDR AENEX AENGV AESAV AETIL AFLYV AFOGI AFVBQ AGEGJ AGRSR AGSTE AHGCF AKBGW ALMA_UNASSIGNED_HOLDINGS ANUXI APEMP ASKNT AUDPV BLAPV BSQNT C6K EBS ECGLT EE0 EF- GGIMP H13 HZ~ H~N J3I O-G O9- OK1 RAOCF RCNCU RPMJG RRC RSCEA RVUXY CGR CUY CVF ECM EIF NPM AAYXX CITATION 7SR 8BQ 8FD JG9 7X8 |
ID | FETCH-LOGICAL-c337t-a9dc624be590aa8600cfca88aa1aea2cc826e5d007d8c5211f3999cf4a9af7273 |
ISSN | 2047-4830 |
IngestDate | Fri Oct 25 04:57:06 EDT 2024 Thu Oct 10 17:07:46 EDT 2024 Fri Dec 06 01:39:08 EST 2024 Sat Nov 02 12:13:03 EDT 2024 Tue Dec 17 20:58:16 EST 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 1 |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c337t-a9dc624be590aa8600cfca88aa1aea2cc826e5d007d8c5211f3999cf4a9af7273 |
Notes | Electronic supplementary information (ESI) available. See DOI https://doi.org/10.1039/d3bm01172k ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ORCID | 0000-0002-5428-7575 0000-0003-1303-4165 0000-0002-2486-196X 0000-0001-6121-4676 |
PMID | 37933486 |
PQID | 2903355514 |
PQPubID | 2047520 |
PageCount | 17 |
ParticipantIDs | crossref_primary_10_1039_D3BM01172K pubmed_primary_37933486 rsc_primary_d3bm01172k proquest_journals_2903355514 proquest_miscellaneous_2886939569 |
PublicationCentury | 2000 |
PublicationDate | 2023-12-19 |
PublicationDateYYYYMMDD | 2023-12-19 |
PublicationDate_xml | – month: 12 year: 2023 text: 2023-12-19 day: 19 |
PublicationDecade | 2020 |
PublicationPlace | England |
PublicationPlace_xml | – name: England – name: Cambridge |
PublicationTitle | Biomaterials science |
PublicationTitleAlternate | Biomater Sci |
PublicationYear | 2023 |
Publisher | Royal Society of Chemistry |
Publisher_xml | – name: Royal Society of Chemistry |
References | Wang (D3BM01172K/cit36/1) 2017; 9 Bankhead (D3BM01172K/cit48/1) 2017; 7 Cobbett (D3BM01172K/cit65/1) 1962; 84 Martino (D3BM01172K/cit35/1) 2015; 1 Bello (D3BM01172K/cit37/1) 2020; 26 Atienza-Roca (D3BM01172K/cit41/1) 2020; 8 Lan (D3BM01172K/cit78/1) 2021; 204 Nafea (D3BM01172K/cit12/1) 2015; 103 Hu (D3BM01172K/cit21/1) 2012; 33 Tan (D3BM01172K/cit29/1) 2011; 6 Lim (D3BM01172K/cit42/1) 2015; 15 Lai (D3BM01172K/cit84/1) 2022; 218 Jeong (D3BM01172K/cit52/1) 2022; 30 Mastrullo (D3BM01172K/cit20/1) 2020; 8 Lyu (D3BM01172K/cit67/1) 2021; 26 Sacchi (D3BM01172K/cit26/1) 2014; 111 Koolen (D3BM01172K/cit47/1) 2019; 38 Chiu (D3BM01172K/cit31/1) 2011; 5 Hao (D3BM01172K/cit57/1) 2020; 108 Hutchings (D3BM01172K/cit61/1) 2003; 17 Campillo-Fernández (D3BM01172K/cit55/1) 2008; 15 Unal (D3BM01172K/cit3/1) 2020; 31 Lazarous (D3BM01172K/cit24/1) 1996; 94 Chokoza (D3BM01172K/cit4/1) 2019; 5 Rojek (D3BM01172K/cit85/1) 2022; 122 Anderson (D3BM01172K/cit22/1) 2011; 32 Huang (D3BM01172K/cit58/1) 2005; 26 Abdallah (D3BM01172K/cit74/1) 2017; 54 Van Hoorick (D3BM01172K/cit14/1) 2019; 97 Huettner (D3BM01172K/cit11/1) 2018; 36 Barros (D3BM01172K/cit9/1) 2019; 192 Su (D3BM01172K/cit13/1) 2015; 37 Kim (D3BM01172K/cit75/1) 2020; 188 Ziats (D3BM01172K/cit56/1) 1993; 17 Babavalian (D3BM01172K/cit66/1) 2014; 1 Ribatti (D3BM01172K/cit69/1) 2021; 405 Phelps (D3BM01172K/cit80/1) 2015; 5 Karvinen (D3BM01172K/cit28/1) 2011; 18 Merkle (D3BM01172K/cit51/1) 2015; 27 Bolívar-Monsalve (D3BM01172K/cit2/1) 2021; 2 Marchioli (D3BM01172K/cit19/1) 2016; 5 Chapla (D3BM01172K/cit8/1) 2021; 3 Mori da Cunha (D3BM01172K/cit5/1) 2020; 106 Cerroni (D3BM01172K/cit76/1) 2018; 4 Dreesmann (D3BM01172K/cit38/1) 2007; 28 Davidenko (D3BM01172K/cit82/1) 2016; 27 Percie du Sert (D3BM01172K/cit45/1) 2020; 18 Vlahakis (D3BM01172K/cit60/1) 2007; 282 Xu (D3BM01172K/cit1/1) 2022; 10 Fu (D3BM01172K/cit34/1) 2017; 58 Byzova (D3BM01172K/cit63/1) 2000; 6 Ozawa (D3BM01172K/cit27/1) 2004; 113 Jia (D3BM01172K/cit10/1) 2016; 45 Saotome (D3BM01172K/cit54/1) 2015; 3 Echave (D3BM01172K/cit18/1) 2019; 562 Guerrero (D3BM01172K/cit64/1) 2020; 12 Ramadhan (D3BM01172K/cit50/1) 2019; 2 Mann (D3BM01172K/cit33/1) 2001; 22 Mony (D3BM01172K/cit40/1) 2021; 4 Tang (D3BM01172K/cit72/1) 2022; 11 Zhang (D3BM01172K/cit15/1) 2022; 219 Adelnia (D3BM01172K/cit73/1) 2022; 164 Oliviero (D3BM01172K/cit71/1) 2012; 8 Otsu (D3BM01172K/cit44/1) 1979; 9 Ma (D3BM01172K/cit83/1) 2022; 13 Soliman (D3BM01172K/cit46/1) 2023; 33 Monchaux (D3BM01172K/cit53/1) 2007; 8 Chuang (D3BM01172K/cit79/1) 2015; 19 Turturro (D3BM01172K/cit77/1) 2013; 8 Lim (D3BM01172K/cit17/1) 2013; 34 Qaum (D3BM01172K/cit30/1) 2001; 42 Kopeć (D3BM01172K/cit16/1) 2022; 134 Traub (D3BM01172K/cit62/1) 2013; 34 Li (D3BM01172K/cit70/1) 2015; 13 Ribatti (D3BM01172K/cit68/1) 2020; 131 Shalumon (D3BM01172K/cit49/1) 2015; 72 Tang (D3BM01172K/cit81/1) 2020; 6 Masters (D3BM01172K/cit32/1) 2011; 11 Wang (D3BM01172K/cit39/1) 2022; 11 Trujillo (D3BM01172K/cit7/1) 2020; 252 Post (D3BM01172K/cit59/1) 2019; 47 Gianni-Barrera (D3BM01172K/cit25/1) 2020; 9 Lin (D3BM01172K/cit43/1) 2020; 7 Wang (D3BM01172K/cit6/1) 2021; 135 Mizuno (D3BM01172K/cit23/1) 2019; 13 |
References_xml | – volume: 134 start-page: 112544 year: 2022 ident: D3BM01172K/cit16/1 publication-title: Biomater. Adv. doi: 10.1016/j.msec.2021.112544 contributor: fullname: Kopeć – volume: 34 start-page: 7097 year: 2013 ident: D3BM01172K/cit17/1 publication-title: Biomaterials doi: 10.1016/j.biomaterials.2013.06.005 contributor: fullname: Lim – volume: 135 start-page: 260 year: 2021 ident: D3BM01172K/cit6/1 publication-title: Acta Biomater. doi: 10.1016/j.actbio.2021.08.038 contributor: fullname: Wang – volume: 2 start-page: 4447 year: 2021 ident: D3BM01172K/cit2/1 publication-title: Mater. Adv. doi: 10.1039/D1MA00092F contributor: fullname: Bolívar-Monsalve – volume: 27 start-page: 148 year: 2016 ident: D3BM01172K/cit82/1 publication-title: J. Mater. Sci. Mater. Med. doi: 10.1007/s10856-016-5763-9 contributor: fullname: Davidenko – volume: 47 start-page: 366 year: 2019 ident: D3BM01172K/cit59/1 publication-title: Ann. Biomed. Eng. doi: 10.1007/s10439-018-02171-3 contributor: fullname: Post – volume: 204 start-page: 109652 year: 2021 ident: D3BM01172K/cit78/1 publication-title: Mater. Des. doi: 10.1016/j.matdes.2021.109652 contributor: fullname: Lan – volume: 282 start-page: 15187 year: 2007 ident: D3BM01172K/cit60/1 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M609323200 contributor: fullname: Vlahakis – volume: 15 start-page: 1331 year: 2008 ident: D3BM01172K/cit55/1 publication-title: Tissue Eng., Part A doi: 10.1089/ten.tea.2008.0146 contributor: fullname: Campillo-Fernández – volume: 111 start-page: 6952 year: 2014 ident: D3BM01172K/cit26/1 publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.1404605111 contributor: fullname: Sacchi – volume: 26 start-page: 164 year: 2020 ident: D3BM01172K/cit37/1 publication-title: Tissue Eng., Part B doi: 10.1089/ten.teb.2019.0256 contributor: fullname: Bello – volume: 13 start-page: 327 year: 2022 ident: D3BM01172K/cit83/1 publication-title: Stem Cell Res. Ther. doi: 10.1186/s13287-022-03009-5 contributor: fullname: Ma – volume: 11 start-page: 1149 year: 2011 ident: D3BM01172K/cit32/1 publication-title: Macromol. Biosci. doi: 10.1002/mabi.201000505 contributor: fullname: Masters – volume: 8 start-page: 5005 year: 2020 ident: D3BM01172K/cit41/1 publication-title: Biomater. Sci. doi: 10.1039/D0BM00603C contributor: fullname: Atienza-Roca – volume: 38 start-page: 94 year: 2019 ident: D3BM01172K/cit47/1 publication-title: Eur. Cells Mater. doi: 10.22203/eCM.v038a08 contributor: fullname: Koolen – volume: 58 start-page: 225 year: 2017 ident: D3BM01172K/cit34/1 publication-title: Acta Biomater. doi: 10.1016/j.actbio.2017.06.012 contributor: fullname: Fu – volume: 30 start-page: 223 year: 2022 ident: D3BM01172K/cit52/1 publication-title: Macromol. Res. doi: 10.1007/s13233-022-0027-7 contributor: fullname: Jeong – volume: 34 start-page: 5958 year: 2013 ident: D3BM01172K/cit62/1 publication-title: Biomaterials doi: 10.1016/j.biomaterials.2013.04.050 contributor: fullname: Traub – volume: 122 start-page: 16839 year: 2022 ident: D3BM01172K/cit85/1 publication-title: Chem. Rev. doi: 10.1021/acs.chemrev.1c00798 contributor: fullname: Rojek – volume: 9 start-page: e435 year: 2017 ident: D3BM01172K/cit36/1 publication-title: NPG Asia Mater. doi: 10.1038/am.2017.171 contributor: fullname: Wang – volume: 33 start-page: 8082 year: 2012 ident: D3BM01172K/cit21/1 publication-title: Biomaterials doi: 10.1016/j.biomaterials.2012.07.057 contributor: fullname: Hu – volume: 45 start-page: 110 year: 2016 ident: D3BM01172K/cit10/1 publication-title: Acta Biomater. doi: 10.1016/j.actbio.2016.09.006 contributor: fullname: Jia – volume: 2 start-page: 2600 year: 2019 ident: D3BM01172K/cit50/1 publication-title: ACS Appl. Bio Mater. doi: 10.1021/acsabm.9b00275 contributor: fullname: Ramadhan – volume: 3 start-page: 7109 year: 2015 ident: D3BM01172K/cit54/1 publication-title: J. Mater. Chem. B doi: 10.1039/C5TB00939A contributor: fullname: Saotome – volume: 6 start-page: 1476 year: 2020 ident: D3BM01172K/cit81/1 publication-title: ACS Biomater. Sci. Eng. doi: 10.1021/acsbiomaterials.9b01624 contributor: fullname: Tang – volume: 8 start-page: 188 year: 2020 ident: D3BM01172K/cit20/1 publication-title: Front. Bioeng. Biotechnol. doi: 10.3389/fbioe.2020.00188 contributor: fullname: Mastrullo – volume: 54 start-page: 150 year: 2017 ident: D3BM01172K/cit74/1 publication-title: Acta Biomater. doi: 10.1016/j.actbio.2017.02.044 contributor: fullname: Abdallah – volume: 10 start-page: 849831 year: 2022 ident: D3BM01172K/cit1/1 publication-title: Front. Bioeng. Biotechnol. doi: 10.3389/fbioe.2022.849831 contributor: fullname: Xu – volume: 6 start-page: 929 year: 2011 ident: D3BM01172K/cit29/1 publication-title: Int. J. Nanomed. doi: 10.2147/IJN.S18753 contributor: fullname: Tan – volume: 131 start-page: 104026 year: 2020 ident: D3BM01172K/cit68/1 publication-title: Microvasc. Res. doi: 10.1016/j.mvr.2020.104026 contributor: fullname: Ribatti – volume: 26 start-page: 7616 year: 2005 ident: D3BM01172K/cit58/1 publication-title: Biomaterials doi: 10.1016/j.biomaterials.2005.05.036 contributor: fullname: Huang – volume: 108 start-page: 178 year: 2020 ident: D3BM01172K/cit57/1 publication-title: Acta Biomater. doi: 10.1016/j.actbio.2020.03.005 contributor: fullname: Hao – volume: 6 start-page: 851 year: 2000 ident: D3BM01172K/cit63/1 publication-title: Mol. Cell contributor: fullname: Byzova – volume: 1 start-page: 83 year: 2014 ident: D3BM01172K/cit66/1 publication-title: J. Appl. Biotechnol. Rep. contributor: fullname: Babavalian – volume: 11 start-page: 2100312 year: 2022 ident: D3BM01172K/cit72/1 publication-title: Adv. Healthcare Mater. doi: 10.1002/adhm.202100312 contributor: fullname: Tang – volume: 17 start-page: 710 year: 1993 ident: D3BM01172K/cit56/1 publication-title: J. Vasc. Surg. doi: 10.1016/0741-5214(93)90115-3 contributor: fullname: Ziats – volume: 405 start-page: 112716 year: 2021 ident: D3BM01172K/cit69/1 publication-title: Exp. Cell Res. doi: 10.1016/j.yexcr.2021.112716 contributor: fullname: Ribatti – volume: 15 start-page: 1423 issue: 10 year: 2015 ident: D3BM01172K/cit42/1 publication-title: Cham contributor: fullname: Lim – volume: 562 start-page: 151 year: 2019 ident: D3BM01172K/cit18/1 publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2019.02.043 contributor: fullname: Echave – volume: 103 start-page: 3727 year: 2015 ident: D3BM01172K/cit12/1 publication-title: J. Biomed. Mater. Res., Part A doi: 10.1002/jbm.a.35510 contributor: fullname: Nafea – volume: 97 start-page: 46 year: 2019 ident: D3BM01172K/cit14/1 publication-title: Acta Biomater. doi: 10.1016/j.actbio.2019.07.035 contributor: fullname: Van Hoorick – volume: 7 start-page: 2000900 year: 2020 ident: D3BM01172K/cit43/1 publication-title: Adv. Sci. doi: 10.1002/advs.202000900 contributor: fullname: Lin – volume: 218 start-page: 110663 year: 2022 ident: D3BM01172K/cit84/1 publication-title: Mater. Des. doi: 10.1016/j.matdes.2022.110663 contributor: fullname: Lai – volume: 5 start-page: 69 year: 2011 ident: D3BM01172K/cit31/1 publication-title: J. Tissue Eng. Regener. Med. doi: 10.1002/term.292 contributor: fullname: Chiu – volume: 26 start-page: 873 issue: 4 year: 2021 ident: D3BM01172K/cit67/1 publication-title: Molecules doi: 10.3390/molecules26040873 contributor: fullname: Lyu – volume: 219 start-page: 672 year: 2022 ident: D3BM01172K/cit15/1 publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2022.08.025 contributor: fullname: Zhang – volume: 11 start-page: 2102818 year: 2022 ident: D3BM01172K/cit39/1 publication-title: Adv. Healthcare Mater. doi: 10.1002/adhm.202102818 contributor: fullname: Wang – volume: 8 start-page: e58897 year: 2013 ident: D3BM01172K/cit77/1 publication-title: PLoS One doi: 10.1371/journal.pone.0058897 contributor: fullname: Turturro – volume: 188 start-page: 110756 year: 2020 ident: D3BM01172K/cit75/1 publication-title: Colloids Surf., B doi: 10.1016/j.colsurfb.2019.110756 contributor: fullname: Kim – volume: 113 start-page: 516 year: 2004 ident: D3BM01172K/cit27/1 publication-title: J. Clin. Invest. doi: 10.1172/JCI18420 contributor: fullname: Ozawa – volume: 27 start-page: 77 year: 2015 ident: D3BM01172K/cit51/1 publication-title: Acta Biomater. doi: 10.1016/j.actbio.2015.08.044 contributor: fullname: Merkle – volume: 9 start-page: 62 year: 1979 ident: D3BM01172K/cit44/1 publication-title: IEEE Trans. Syst., Man, Cyber. doi: 10.1109/TSMC.1979.4310076 contributor: fullname: Otsu – volume: 17 start-page: 1520 year: 2003 ident: D3BM01172K/cit61/1 publication-title: FASEB J. doi: 10.1096/fj.02-0691fje contributor: fullname: Hutchings – volume: 42 start-page: 2408 year: 2001 ident: D3BM01172K/cit30/1 publication-title: Invest. Ophthalmol. Visual Sci. contributor: fullname: Qaum – volume: 18 start-page: 1166 year: 2011 ident: D3BM01172K/cit28/1 publication-title: Gene Ther. doi: 10.1038/gt.2011.66 contributor: fullname: Karvinen – volume: 252 start-page: 120104 year: 2020 ident: D3BM01172K/cit7/1 publication-title: Biomaterials doi: 10.1016/j.biomaterials.2020.120104 contributor: fullname: Trujillo – volume: 5 start-page: 125 year: 2015 ident: D3BM01172K/cit80/1 publication-title: Drug Delivery Transl. Res. doi: 10.1007/s13346-013-0142-2 contributor: fullname: Phelps – volume: 22 start-page: 439 year: 2001 ident: D3BM01172K/cit33/1 publication-title: Biomaterials doi: 10.1016/S0142-9612(00)00196-4 contributor: fullname: Mann – volume: 31 start-page: 2253 year: 2020 ident: D3BM01172K/cit3/1 publication-title: Bioconjugate Chem. doi: 10.1021/acs.bioconjchem.0c00270 contributor: fullname: Unal – volume: 36 start-page: 372 year: 2018 ident: D3BM01172K/cit11/1 publication-title: Trends Biotechnol. doi: 10.1016/j.tibtech.2018.01.008 contributor: fullname: Huettner – volume: 9 start-page: 433 year: 2020 ident: D3BM01172K/cit25/1 publication-title: Stem Cells Transl. Med. doi: 10.1002/sctm.19-0319 contributor: fullname: Gianni-Barrera – volume: 18 start-page: e3000410 year: 2020 ident: D3BM01172K/cit45/1 publication-title: PLos Biol. doi: 10.1371/journal.pbio.3000410 contributor: fullname: Percie du Sert – volume: 13 start-page: 2291 year: 2019 ident: D3BM01172K/cit23/1 publication-title: J. Tissue Eng. Regener. Med. doi: 10.1002/term.2957 contributor: fullname: Mizuno – volume: 33 start-page: 2210521 year: 2023 ident: D3BM01172K/cit46/1 publication-title: Adv. Funct. Mater. doi: 10.1002/adfm.202210521 contributor: fullname: Soliman – volume: 8 start-page: 3294 year: 2012 ident: D3BM01172K/cit71/1 publication-title: Acta Biomater. doi: 10.1016/j.actbio.2012.05.019 contributor: fullname: Oliviero – volume: 8 start-page: 3668 year: 2007 ident: D3BM01172K/cit53/1 publication-title: Biomacromolecules doi: 10.1021/bm7007907 contributor: fullname: Monchaux – volume: 84 start-page: 468 year: 1962 ident: D3BM01172K/cit65/1 publication-title: Biochem. J. doi: 10.1042/bj0840468 contributor: fullname: Cobbett – volume: 1 start-page: 3 year: 2015 ident: D3BM01172K/cit35/1 publication-title: Front. Bioeng. Biotechnol. contributor: fullname: Martino – volume: 192 start-page: 601 year: 2019 ident: D3BM01172K/cit9/1 publication-title: Biomaterials doi: 10.1016/j.biomaterials.2018.10.039 contributor: fullname: Barros – volume: 5 start-page: 5430 year: 2019 ident: D3BM01172K/cit4/1 publication-title: ACS Biomater. Sci. Eng. doi: 10.1021/acsbiomaterials.9b01220 contributor: fullname: Chokoza – volume: 37 start-page: 2139 year: 2015 ident: D3BM01172K/cit13/1 publication-title: Biotechnol. Lett. doi: 10.1007/s10529-015-1907-0 contributor: fullname: Su – volume: 94 start-page: 1074 year: 1996 ident: D3BM01172K/cit24/1 publication-title: Circulation doi: 10.1161/01.CIR.94.5.1074 contributor: fullname: Lazarous – volume: 4 start-page: 3320 year: 2021 ident: D3BM01172K/cit40/1 publication-title: ACS Appl. Bio Mater. doi: 10.1021/acsabm.0c01648 contributor: fullname: Mony – volume: 28 start-page: 5536 year: 2007 ident: D3BM01172K/cit38/1 publication-title: Biomaterials doi: 10.1016/j.biomaterials.2007.08.040 contributor: fullname: Dreesmann – volume: 5 start-page: 1606 year: 2016 ident: D3BM01172K/cit19/1 publication-title: Adv. Healthcare Mater. doi: 10.1002/adhm.201600058 contributor: fullname: Marchioli – volume: 19 start-page: 85 year: 2015 ident: D3BM01172K/cit79/1 publication-title: Acta Biomater. doi: 10.1016/j.actbio.2015.02.024 contributor: fullname: Chuang – volume: 12 start-page: 570 year: 2020 ident: D3BM01172K/cit64/1 publication-title: Polymers doi: 10.3390/polym12030570 contributor: fullname: Guerrero – volume: 106 start-page: 82 year: 2020 ident: D3BM01172K/cit5/1 publication-title: Acta Biomater. doi: 10.1016/j.actbio.2020.01.041 contributor: fullname: Mori da Cunha – volume: 3 start-page: 012002 year: 2021 ident: D3BM01172K/cit8/1 publication-title: Prog. Biomed. Eng. doi: 10.1088/2516-1091/abc947 contributor: fullname: Chapla – volume: 164 start-page: 110974 year: 2022 ident: D3BM01172K/cit73/1 publication-title: Eur. Polym. J. doi: 10.1016/j.eurpolymj.2021.110974 contributor: fullname: Adelnia – volume: 4 start-page: e00770 year: 2018 ident: D3BM01172K/cit76/1 publication-title: Heliyon doi: 10.1016/j.heliyon.2018.e00770 contributor: fullname: Cerroni – volume: 32 start-page: 7432 year: 2011 ident: D3BM01172K/cit22/1 publication-title: Biomaterials doi: 10.1016/j.biomaterials.2011.06.027 contributor: fullname: Anderson – volume: 13 start-page: 88 year: 2015 ident: D3BM01172K/cit70/1 publication-title: Acta Biomater. doi: 10.1016/j.actbio.2014.11.002 contributor: fullname: Li – volume: 7 start-page: 16878 year: 2017 ident: D3BM01172K/cit48/1 publication-title: Sci. Rep. doi: 10.1038/s41598-017-17204-5 contributor: fullname: Bankhead – volume: 72 start-page: 1048 year: 2015 ident: D3BM01172K/cit49/1 publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2014.09.058 contributor: fullname: Shalumon |
SSID | ssj0000779061 |
Score | 2.3852706 |
Snippet | Synthetic polymers, such as poly(vinyl alcohol) (PVA), are popular biomaterials for the fabrication of hydrogels for tissue engineering and regenerative... |
SourceID | proquest crossref pubmed rsc |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 134 |
SubjectTerms | Animals Biocompatible Materials - chemistry Biocompatible Materials - pharmacology Biomedical materials Blood vessels Chemical properties Constraining Controlled release Endothelial cells Ethanol Gelatin Gelatin - chemistry Growth factors Hydrogels Hydrogels - chemistry Infiltration Mice Physical properties Polymers - chemistry Polyvinyl alcohol Polyvinyl Alcohol - chemistry Surgical implants Tissue Engineering Vascular endothelial growth factor Vascular Endothelial Growth Factor A |
Title | Pristine gelatin incorporation as a strategy to enhance the biofunctionality of poly(vinyl alcohol)-based hydrogels for tissue engineering applications |
URI | https://www.ncbi.nlm.nih.gov/pubmed/37933486 https://www.proquest.com/docview/2903355514 https://search.proquest.com/docview/2886939569 |
Volume | 12 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLZK9wIPiNugMJARIIGilMZOsvhxg8GAFSHRSXurHMe9cEmmXpDKH-Ef8bs4x3bcdOVh8BJVbmu3OV_O-Wwff4eQpzKKFVbSDjXLRRjHOQ9zpZMQSxXCfCJXCcOzw_2P6fFp_P4sOWu1fjeylpaLvKt-_vVcyf9YFdrArnhK9h8s6zuFBngN9oUrWBiul7LxJ_OEAk0cm5Q2TFpUTpnYZBnPAxnMrfysIZm6nJgTAkg282mFMc0uBbq8jPMK605nP6blChOXTfHcZ0yEGOqKYLIqZhWMNLepicZi0KXXMwyam-Ebm8XTCnixvSGBC7k-Eagqx5UpK4VnbeAB9WGiL7_YpYS3MyD234LPXZ_tM60XuSeyWi3X-EZFyeXYpv8ezlBMNDjpNtc1GMccEec9jftjqCERZ27XRjfbrMip999sC6fWGUdumdTG9cgK3G6FjB5HxdXX_LCP8njswzow1skAF-Klz2I0-_dcDNffvUJ2UJAxbpOdg6PBuxO_2tdDWUcj3uv_Vq2Vy8XLdQeb7GhrygMEaFYXpjEEaHCDXHczF3pgYXiTtHR5i1xr6FneJr9qQFIHSLoBSCrnVNIakHRRUQdICoCkFwFJqxFFQD43cKQOji8sGKkHIwUwUgtG2gAjbYLxDjl9czR4dRy6yh-h4nx_EUpRqJTFuU5ET8oMSLkaKZllUkZSS6YUTIp1UsBtLTLwJlE0Ap4t1CiWQo6Qke-SdlmV-h6hrNAyilSaxVrHKIOri32JddcYdKUy1SFP6js-PLcCL8Ntw3bIXm2MoXMA8yETPQ50HaYcHfLYvw3uGffcZKmrJXwmy1LBRZKKDrlrjeiH4RAbeZylHbILVvXNBc-_m1G_3r_Ub3tArq6fnz3SXsyW-iEw5UX-yMHwD9T8xY0 |
link.rule.ids | 314,780,784,27924,27925 |
linkProvider | Royal Society of Chemistry |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Pristine+gelatin+incorporation+as+a+strategy+to+enhance+the+biofunctionality+of+poly%28vinyl+alcohol%29-based+hydrogels+for+tissue+engineering+applications&rft.jtitle=Biomaterials+science&rft.au=Longoni%2C+Alessia&rft.au=Major%2C+Gretel+S.&rft.au=Jiang%2C+Shaoyuan&rft.au=Farrugia%2C+Brooke+L.&rft.date=2023-12-19&rft.issn=2047-4830&rft.eissn=2047-4849&rft.volume=12&rft.issue=1&rft.spage=134&rft.epage=150&rft_id=info:doi/10.1039%2FD3BM01172K&rft.externalDBID=n%2Fa&rft.externalDocID=10_1039_D3BM01172K |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2047-4830&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2047-4830&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2047-4830&client=summon |