Interferon-β and serum 25-hydroxyvitamin D interact to modulate relapse risk in MS

• Published in: Neurology Vol. 79; no. 3; p. 254
• Main Authors: Stewart, Niall, Simpson, Jr, Steve, van der Mei, Ingrid, Ponsonby, Anne-Louise, Blizzard, Leigh, Dwyer, Terrence, Pittas, Fotini, Eyles, Darryl, Ko, Pauline, Taylor, Bruce V
• Format: Journal Article
• Language: English
• Published: United States 17.07.2012
• Subjects: Adult; Aged; Body Mass Index; Cohort Studies; Evidence-Based Medicine; Female; Forecasting; Humans; Immunologic Factors - adverse effects; Immunologic Factors - therapeutic use; Interferon-beta - adverse effects; Interferon-beta - therapeutic use; Kaplan-Meier Estimate; Longitudinal Studies; Male; Middle Aged; Multiple Sclerosis - blood; Multiple Sclerosis - drug therapy; Proportional Hazards Models; Prospective Studies; Recurrence; Sunlight; Survival Analysis; Ultraviolet Rays; Vitamin D - analogs & derivatives; Vitamin D - blood; Young Adult

To determine whether interferon-β (IFN-β) medication use is associated with vitamin D levels and whether the two interact in exerting effects on relapse risk. In a prospective cohort of 178 persons with clinically definite multiple sclerosis (MS) living in southern Tasmania in 2002-2005, serum 25-hy...