Self-assembly of hydrazide-linked porous organic polymers rich in titanium for efficient enrichment of glycopeptides and phosphopeptides from human serum

• Published in: Analyst (London) Vol. 148; no. 14; pp. 3392 - 342
• Main Authors: Wang, Danni, Feng, Quanshou, Luo, Yiting, Wang, Weimin, Yan, Yinghua, Ding, Chuan-Fan
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 10.07.2023
• Subjects: Breast cancer; Enrichment; Glycopeptides; Glycopeptides - analysis; Glycoproteins; Humans; Hydrazines; Oxidation; Phosphopeptides - analysis; Phosphoproteins; Polymers; Porosity; Self-assembly; Titanium

In this work, titanium-rich hydrazide-linked porous organic polymers (hydrazide-POPs-Ti 4+ ) were synthesized using hydrazine, 2,3-dihydroxyterephthalaldehyde (DHTA) and trimethyl 1,3,5-benzenetricarboxylate (TP) as the ligands. Hydrazide-POPs-Ti 4+ combined with HILIC and IMAC can be used for simul...