Polymer-grafted hollow mesoporous silica nanoparticles integrated with microneedle patches for glucose-responsive drug delivery

A glucose-mediated drug delivery system would be highly satisfactory for diabetes diagnosis since it can intelligently release drug based on blood glucose levels. Herein, a glucose-responsive drug delivery system by integrating glucose-responsive poly(3-acrylamidophenylboronic acid) (PAPBA) function...

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Published inFrontiers of materials science Vol. 15; no. 1; pp. 98 - 112
Main Authors WANG, Yaping, CHENG, Songyue, HU, Wei, LIN, Xue, CAO, Cong, ZOU, Shufen, TONG, Zaizai, JIANG, Guohua, KONG, Xiangdong
Format Journal Article
LanguageEnglish
Published Beijing Higher Education Press 01.03.2021
Subjects
Chemistry and Materials Science
diabetes
glucose-responsive release
hollow mesoporous silica nanoparticles
Materials Science
microneedles
Research Article
transdermal delivery
microneedles
transdermal delivery
diabetes
glucose-responsive release
hollow mesoporous silica nanoparticles
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Abstract A glucose-mediated drug delivery system would be highly satisfactory for diabetes diagnosis since it can intelligently release drug based on blood glucose levels. Herein, a glucose-responsive drug delivery system by integrating glucose-responsive poly(3-acrylamidophenylboronic acid) (PAPBA) functionalized hollow mesoporous silica nanoparticles (HMSNs) with transcutaneous microneedles (MNs) has been designed. The grafted PAPBA serves as gatekeeper to prevent drug release from HMSNs at normoglycemic levels. In contrast, faster drug release is detected at a typical hyperglycemic level, which is due to the change of hydrophilicity of PAPBA at high glucose concentration. After transdermal administration to diabetic rats, an effective hypoglycemic effect is achieved compared with that of subcutaneous injection. These observations indicate that the designed glucose-responsive drug delivery system has a potential application in diabetes treatment.
AbstractList A glucose-mediated drug delivery system would be highly satisfactory for diabetes diagnosis since it can intelligently release drug based on blood glucose levels. Herein, a glucose-responsive drug delivery system by integrating glucose-responsive poly(3-acrylamidophenylboronic acid) (PAPBA) functionalized hollow mesoporous silica nanoparticles (HMSNs) with transcutaneous microneedles (MNs) has been designed. The grafted PAPBA serves as gatekeeper to prevent drug release from HMSNs at normoglycemic levels. In contrast, faster drug release is detected at a typical hyperglycemic level, which is due to the change of hydrophilicity of PAPBA at high glucose concentration. After transdermal administration to diabetic rats, an effective hypoglycemic effect is achieved compared with that of subcutaneous injection. These observations indicate that the designed glucose-responsive drug delivery system has a potential application in diabetes treatment.
Author WANG, Yaping
CAO, Cong
HU, Wei
ZOU, Shufen
LIN, Xue
TONG, Zaizai
KONG, Xiangdong
CHENG, Songyue
JIANG, Guohua
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  givenname: Songyue
  surname: CHENG
  fullname: CHENG, Songyue
  organization: College of Materials Science and Engineering & Institute of Smart Biomedical Materials & Zhejiang-Mauritius Joint Research Center for Biomaterials and Tissue Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China
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  givenname: Wei
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  organization: College of Materials Science and Engineering & Institute of Smart Biomedical Materials & Zhejiang-Mauritius Joint Research Center for Biomaterials and Tissue Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China
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  givenname: Xue
  surname: LIN
  fullname: LIN, Xue
  organization: College of Materials Science and Engineering & Institute of Smart Biomedical Materials & Zhejiang-Mauritius Joint Research Center for Biomaterials and Tissue Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China
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  givenname: Cong
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  givenname: Shufen
  surname: ZOU
  fullname: ZOU, Shufen
  organization: Jiangxi Province Key Laboratory of Polymer Micro/Nano Manufacturing and Devices, School of Chemistry, Biology and Materials Science, East China University of Technology, Nanchang 330013, China
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  givenname: Zaizai
  surname: TONG
  fullname: TONG, Zaizai
  email: tongzz@zstu.edu.cn
  organization: College of Materials Science and Engineering & Institute of Smart Biomedical Materials & Zhejiang-Mauritius Joint Research Center for Biomaterials and Tissue Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China
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– sequence: 9
  givenname: Xiangdong
  surname: KONG
  fullname: KONG, Xiangdong
  organization: College of Materials Science and Engineering & Institute of Smart Biomedical Materials & Zhejiang-Mauritius Joint Research Center for Biomaterials and Tissue Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China
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Issue 1
Keywords microneedles
transdermal delivery
diabetes
glucose-responsive release
hollow mesoporous silica nanoparticles
Language English
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Notes Document received on :2020-07-09
microneedles
transdermal delivery
diabetes
glucose-responsive release
Document accepted on :2020-09-28
hollow mesoporous silica nanoparticles
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Snippet A glucose-mediated drug delivery system would be highly satisfactory for diabetes diagnosis since it can intelligently release drug based on blood glucose...
SourceID crossref
springer
higheredpress
SourceType Enrichment Source
Index Database
Publisher
StartPage 98
SubjectTerms Chemistry and Materials Science
diabetes
glucose-responsive release
hollow mesoporous silica nanoparticles
Materials Science
microneedles
Research Article
transdermal delivery
Title Polymer-grafted hollow mesoporous silica nanoparticles integrated with microneedle patches for glucose-responsive drug delivery
URI https://journal.hep.com.cn/foms/EN/10.1007/s11706-021-0532-1
https://link.springer.com/article/10.1007/s11706-021-0532-1
Volume 15
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