Reactivity and mechanism of α-nucleophile scaffolds as catalytic organophosphate scavengers

• Published in: Organic & biomolecular chemistry Vol. 17; no. 16; pp. 3951 - 3963
• Main Authors: Wong, Pamela T, Bhattacharjee, Somnath, Cannon, Jayme, Tang, Shengzhuang, Yang, Kelly, Bowden, Sierra, Varnau, Victoria, O'Konek, Jessica J, Choi, Seok Ki
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 17.04.2019; Royal Society of Chemistry
• Subjects: Acetylcholinesterase; Catalysis; Chemical reactions; Chemistry; Chemistry, Organic; Decontamination; Esterase; Hydroxamic acid; Inactivators; Lead compounds; Molecular structure; NMR; Nuclear magnetic resonance; Nucleophiles; Organic chemistry; Organophosphates; Paraoxon; Physical Sciences; Physicochemical properties; Pyridinium; Reactivity; Scaffolds; Science & Technology; Screening; Skin; NERVE AGENTS; OXIME REACTIVATORS; PARAOXON; KINETICS; PAMAM DENDRIMERS; SKIN DECONTAMINATION LOTION; WARFARE AGENTS; SARIN; COOPERATIVITY; INHIBITED HUMAN ACETYLCHOLINESTERASE

Despite their unique benefits imparted by their structure and reactivity, certain α-nucleophile molecules remain underexplored as chemical inactivators for the topical decontamination of reactive organophosphates (OPs). Here, we present a library of thirty α-nucleophile scaffolds, each designed with...