The role of solvation on the conformational landscape of α-synuclein

• Published in: Analyst (London) Vol. 149; no. 1; pp. 125 - 136
• Main Authors: Cheung See Kit, Melanie, Cropley, Tyler C, Bleiholder, Christian, Chouinard, Christopher D, Sobott, Frank, Webb, Ian K
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 18.12.2023
• Subjects: Bonding strength; Cations; Cross-sections; Crosslinking; Freezing; Ionic mobility; Mass spectrometry; NMR; Nuclear magnetic resonance; Proteins; Residues; Scientific imaging; Solvation; Vapor phases

Native ion mobility mass spectrometry has been used extensively to characterize ensembles of intrinsically disordered protein (IDP) conformers, but the extent to which the gaseous measurements provide realistic pictures of the solution conformations for such flexible proteins remains unclear. Theref...