Involvement of Immune Responses in the Efficacy of Cord Blood Cell Therapy for Cerebral Palsy

• Published in: Stem cells and development Vol. 24; no. 19; p. 2259
• Main Authors: Kang, Mino, Min, Kyunghoon, Jang, Joonyoung, Kim, Seung Chan, Kang, Myung Seo, Jang, Su Jin, Lee, Ji Young, Kim, Sang Heum, Kim, Moon Kyu, An, SeongSoo A, Kim, MinYoung
• Format: Journal Article
• Language: English
• Published: United States 01.10.2015
• Subjects: Adolescent; Cerebral Palsy - blood; Cerebral Palsy - physiopathology; Cerebral Palsy - therapy; Child; Child, Preschool; Cord Blood Stem Cell Transplantation - methods; Cytokines - blood; Double-Blind Method; Female; Fluorodeoxyglucose F18; Humans; Infant; Male; Muscle Strength - physiology; Positron-Emission Tomography - methods; Receptors, Cytokine - blood; Time Factors; Toll-Like Receptor 2 - blood; Toll-Like Receptor 4 - blood; TOR Serine-Threonine Kinases - blood; Treatment Outcome

This study evaluated the efficacy of umbilical cord blood (UCB) cell for patients with cerebral palsy (CP) in a randomized, placebo-controlled, double-blind trial and also assessed factors and mechanisms related to the efficacy. Thirty-six children (ages 6 months to 20 years old) with CP were enroll...