Injectable hydrogel-mediated combination of hyperthermia ablation and photo-enhanced chemotherapy in the NIR-II window for tumor eradication

Local administration of therapeutic agents with long-term retention capabilities efficiently avoids nonspecific distribution in normal organs with an increased drug concentration in pathological tissue. Herein, we developed an injectable and degradable alginate-calcium (Ca 2+ ) hydrogel for the loca...

Full description

Saved in:
Bibliographic Details
Published inBiomaterials science Vol. 9; no. 9; pp. 3516 - 3525
Main Authors Wang, Gang, Zhang, Na, Cao, Ziyang, Zhang, Zhenghai, Zhu, Zhongming, Sun, Gengyun, Jin, Liangjie, Yang, Xianzhu
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 04.05.2021
Subjects
Ablation
Alginates
Animals
Biocompatibility
Calcium ions
Cell Line, Tumor
Chemical compounds
Chemotherapy
Doxorubicin
Gold
Hydrogels
Hyperthermia
Hyperthermia, Induced
Mice
Nanorods
Near infrared radiation
Neoplasms - therapy
Organs
Pharmacology
Silver
Tumors
Online AccessGet full text

Cover

Abstract Local administration of therapeutic agents with long-term retention capabilities efficiently avoids nonspecific distribution in normal organs with an increased drug concentration in pathological tissue. Herein, we developed an injectable and degradable alginate-calcium (Ca 2+ ) hydrogel for the local administration of corn-like Au/Ag nanorods (NRs) and doxorubicin hydrochloride (DOX·HCl). The immobilized Au/Ag NRs with strong absorbance in the near-infrared II (NIR-II) window efficiently ablated the majority of tumor cells after 1064 nm laser irradiation and triggered the release of DOX to kill residual tumor cells. As a result, injectable hydrogel-mediated NIR-II photothermal therapy (PTT) and chemotherapy efficiently inhibited tumor growth, resulting in the complete eradication of tumors in most of the treated mice. Furthermore, owing to the confinement of the Au/Ag NRs and DOX·HCl within the hydrogel, such treatment exhibited excellent biocompatibility. An injectable alginate hydrogel was developed for local delivery of corn-like Au/Ag NRs and DOX for combined NIR-II PTT and chemotherapy.
AbstractList Local administration of therapeutic agents with long-term retention capabilities efficiently avoids nonspecific distribution in normal organs with an increased drug concentration in pathological tissue. Herein, we developed an injectable and degradable alginate-calcium (Ca2+) hydrogel for the local administration of corn-like Au/Ag nanorods (NRs) and doxorubicin hydrochloride (DOX·HCl). The immobilized Au/Ag NRs with strong absorbance in the near-infrared II (NIR-II) window efficiently ablated the majority of tumor cells after 1064 nm laser irradiation and triggered the release of DOX to kill residual tumor cells. As a result, injectable hydrogel-mediated NIR-II photothermal therapy (PTT) and chemotherapy efficiently inhibited tumor growth, resulting in the complete eradication of tumors in most of the treated mice. Furthermore, owing to the confinement of the Au/Ag NRs and DOX·HCl within the hydrogel, such treatment exhibited excellent biocompatibility.
Local administration of therapeutic agents with long-term retention capabilities efficiently avoids nonspecific distribution in normal organs with an increased drug concentration in pathological tissue. Herein, we developed an injectable and degradable alginate-calcium (Ca 2+ ) hydrogel for the local administration of corn-like Au/Ag nanorods (NRs) and doxorubicin hydrochloride (DOX·HCl). The immobilized Au/Ag NRs with strong absorbance in the near-infrared II (NIR-II) window efficiently ablated the majority of tumor cells after 1064 nm laser irradiation and triggered the release of DOX to kill residual tumor cells. As a result, injectable hydrogel-mediated NIR-II photothermal therapy (PTT) and chemotherapy efficiently inhibited tumor growth, resulting in the complete eradication of tumors in most of the treated mice. Furthermore, owing to the confinement of the Au/Ag NRs and DOX·HCl within the hydrogel, such treatment exhibited excellent biocompatibility.
Local administration of therapeutic agents with long-term retention capabilities efficiently avoids nonspecific distribution in normal organs with an increased drug concentration in pathological tissue. Herein, we developed an injectable and degradable alginate-calcium (Ca 2+ ) hydrogel for the local administration of corn-like Au/Ag nanorods (NRs) and doxorubicin hydrochloride (DOX·HCl). The immobilized Au/Ag NRs with strong absorbance in the near-infrared II (NIR-II) window efficiently ablated the majority of tumor cells after 1064 nm laser irradiation and triggered the release of DOX to kill residual tumor cells. As a result, injectable hydrogel-mediated NIR-II photothermal therapy (PTT) and chemotherapy efficiently inhibited tumor growth, resulting in the complete eradication of tumors in most of the treated mice. Furthermore, owing to the confinement of the Au/Ag NRs and DOX·HCl within the hydrogel, such treatment exhibited excellent biocompatibility. An injectable alginate hydrogel was developed for local delivery of corn-like Au/Ag NRs and DOX for combined NIR-II PTT and chemotherapy.
Author Zhang, Zhenghai
Sun, Gengyun
Zhu, Zhongming
Yang, Xianzhu
Jin, Liangjie
Zhang, Na
Wang, Gang
Cao, Ziyang
AuthorAffiliation East District of the First Affiliated Hospital of Anhui Medical University
South China University of Technology
Department of Respiratory and Critical Care Medicine
The First Affiliated Hospital of Anhui Medical University
School of Medicine
Respiratory Medicine
AuthorAffiliation_xml – name: School of Medicine
– name: South China University of Technology
– name: Department of Respiratory and Critical Care Medicine
– name: Respiratory Medicine
– name: The First Affiliated Hospital of Anhui Medical University
– name: East District of the First Affiliated Hospital of Anhui Medical University
Author_xml – sequence: 1
  givenname: Gang
  surname: Wang
  fullname: Wang, Gang
– sequence: 2
  givenname: Na
  surname: Zhang
  fullname: Zhang, Na
– sequence: 3
  givenname: Ziyang
  surname: Cao
  fullname: Cao, Ziyang
– sequence: 4
  givenname: Zhenghai
  surname: Zhang
  fullname: Zhang, Zhenghai
– sequence: 5
  givenname: Zhongming
  surname: Zhu
  fullname: Zhu, Zhongming
– sequence: 6
  givenname: Gengyun
  surname: Sun
  fullname: Sun, Gengyun
– sequence: 7
  givenname: Liangjie
  surname: Jin
  fullname: Jin, Liangjie
– sequence: 8
  givenname: Xianzhu
  surname: Yang
  fullname: Yang, Xianzhu
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33949443$$D View this record in MEDLINE/PubMed
BookMark eNpd0Utr3DAQAGARUpI0zSX3BEEvpeBGT3t1bNKXIU2hNGcjWeNaiy25kk3Y_9AfXe1uuoXqIA3MN4OYeYmOffCA0CUl7yjh6sZSMxLCK2qO0BkjoirESqjjQ8zJKbpIaU3yqSpFSnqCTjlXQgnBz9Dv2q-hnbUZAPcbG8NPGIoRrNMzWNyG0TivZxc8Dl0GE8S5hzg6jXPJPqG9xVMf5lCA77Vvt3U9jGEL9bTBzuMc4of6e1HX-Ml5G55wFyKelzHfGVnX7lq9Qi86PSS4eH7P0eOnjz_uvhT33z7Xd-_vi5bzai6k0iXITtrKGCW1VIobW1rDBaWVAUpLnqcCzAptKXSMEyKtkKJTJQe2ovwcvdn3nWL4tUCam9GlFoZBewhLaphkjKsVF1Wmr_-j67BEn3-3VVQyxXbq7V61MaQUoWum6EYdNw0lzXZNzQd6-3W3ptuMr59bLiZP-kD_LiWDqz2IqT1k_-2Z_wFuZ5oC
CitedBy_id crossref_primary_10_3390_gels8050315
crossref_primary_10_1039_D2NR00953F
crossref_primary_10_1016_j_actbio_2024_04_011
crossref_primary_10_1039_D3TB01769A
crossref_primary_10_1039_D3BM00845B
crossref_primary_10_1021_acsami_2c06890
crossref_primary_10_1186_s12951_023_01887_2
crossref_primary_10_1016_j_jconrel_2022_05_049
crossref_primary_10_1016_j_cej_2024_150067
crossref_primary_10_1039_D1BM00679G
Cites_doi 10.1021/acsnano.9b01515
10.1016/j.jconrel.2016.06.015
10.1016/j.pmatsci.2020.100666
10.1002/anie.201712550
10.1093/nsr/nwz201
10.1038/nature08956
10.1021/acs.langmuir.9b03001
10.1002/adma.201602997
10.1016/j.jconrel.2018.12.048
10.1002/adma.201705980
10.1038/s41565-019-0567-y
10.1021/acsnano.9b00452
10.1016/j.biomaterials.2017.06.030
10.1021/acsami.6b07838
10.1038/s41557-018-0055-2
10.1016/j.biomaterials.2016.07.013
10.1038/nrd4685
10.1038/s41551-018-0262-6
10.1039/C9NJ01402K
10.1016/j.biomaterials.2020.120453
10.1016/j.biomaterials.2018.12.025
10.1002/smll.202004161
10.1021/acs.nanolett.9b01716
10.7150/thno.16923
10.1021/acsnano.7b08616
10.1016/j.biomaterials.2019.01.019
10.1016/j.canlet.2017.09.043
10.1021/acs.nanolett.8b04179
10.1002/adma.202002439
10.1016/j.biomaterials.2018.10.046
10.1021/acsnano.5b07882
10.1002/adma.201602486
10.1038/s41467-019-11269-8
10.3390/cancers9020015
10.1002/adma.201506312
10.1021/acs.langmuir.7b00097
10.1016/j.cej.2019.01.095
10.1002/smll.202004879
10.1016/j.biomaterials.2017.10.030
10.1021/acsami.7b02307
10.1021/acs.nanolett.5b01833
10.1016/j.cell.2018.10.049
10.1038/natrevmats.2016.14
10.1016/j.biomaterials.2020.119934
10.1002/adhm.201901101
10.1021/jp064341w
10.1038/natrevmats.2016.69
ContentType Journal Article
Copyright Copyright Royal Society of Chemistry 2021
Copyright_xml – notice: Copyright Royal Society of Chemistry 2021
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7SR
8BQ
8FD
JG9
7X8
DOI 10.1039/d1bm00371b
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
Engineered Materials Abstracts
METADEX
Technology Research Database
Materials Research Database
MEDLINE - Academic
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Materials Research Database
Engineered Materials Abstracts
Technology Research Database
METADEX
MEDLINE - Academic
DatabaseTitleList MEDLINE
Materials Research Database
CrossRef
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Engineering
EISSN 2047-4849
EndPage 3525
ExternalDocumentID 10_1039_D1BM00371B
33949443
d1bm00371b
Genre Journal Article
GroupedDBID 0-7
0R
4.4
53G
705
AAEMU
AAGNR
AAIWI
AANOJ
ABASK
ABDVN
ABGFH
ABRYZ
ACGFS
ACIWK
ACLDK
ADMRA
ADSRN
AENEX
AFVBQ
AGRSR
AGSTE
AGSWI
ALMA_UNASSIGNED_HOLDINGS
ANUXI
ASKNT
AUDPV
BLAPV
BSQNT
C6K
CKLOX
EBS
ECGLT
EE0
EF-
HZ
H~N
J3I
JG
O-G
O9-
OK1
RCNCU
RPMJG
RRC
RSCEA
-JG
0R~
AAHBH
AAJAE
AARTK
AAWGC
AAXHV
ABEMK
ABJNI
ABPDG
ABXOH
AEFDR
AENGV
AESAV
AETIL
AFLYV
AFOGI
AGEGJ
AHGCF
AKBGW
APEMP
CGR
CUY
CVF
ECM
EIF
GGIMP
H13
HZ~
NPM
RAOCF
RVUXY
AAYXX
CITATION
7SR
8BQ
8FD
JG9
7X8
ID FETCH-LOGICAL-c337t-59a6e5f5d7bb95a5993bd6db34117be1163d1be2d4ad1ef23005d454f963e2813
ISSN 2047-4830
IngestDate Fri Aug 16 23:16:48 EDT 2024
Thu Oct 10 17:33:56 EDT 2024
Fri Aug 23 02:59:47 EDT 2024
Sat Sep 28 08:23:33 EDT 2024
Fri Apr 15 11:43:18 EDT 2022
IsPeerReviewed true
IsScholarly true
Issue 9
Language English
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c337t-59a6e5f5d7bb95a5993bd6db34117be1163d1be2d4ad1ef23005d454f963e2813
Notes 10.1039/d1bm00371b
Electronic supplementary information (ESI) available. See DOI
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ORCID 0000-0002-1006-0950
PMID 33949443
PQID 2521529247
PQPubID 2047520
PageCount 1
ParticipantIDs proquest_journals_2521529247
proquest_miscellaneous_2522398347
crossref_primary_10_1039_D1BM00371B
pubmed_primary_33949443
rsc_primary_d1bm00371b
PublicationCentury 2000
PublicationDate 20210504
PublicationDateYYYYMMDD 2021-05-04
PublicationDate_xml – month: 5
  year: 2021
  text: 20210504
  day: 4
PublicationDecade 2020
PublicationPlace England
PublicationPlace_xml – name: England
– name: Cambridge
PublicationTitle Biomaterials science
PublicationTitleAlternate Biomater Sci
PublicationYear 2021
Publisher Royal Society of Chemistry
Publisher_xml – name: Royal Society of Chemistry
References Wang (D1BM00371B-(cit29)/*[position()=1]) 2016; 28
Jiang (D1BM00371B-(cit39)/*[position()=1]) 2018; 30
Xu (D1BM00371B-(cit10)/*[position()=1]) 2018; 414
Dong (D1BM00371B-(cit33)/*[position()=1]) 2020; 32
Tang (D1BM00371B-(cit47)/*[position()=1]) 2018; 154
Wilhelm (D1BM00371B-(cit11)/*[position()=1]) 2016; 1
Yang (D1BM00371B-(cit31)/*[position()=1]) 2016; 10
Zhang (D1BM00371B-(cit41)/*[position()=1]) 2020; 243
Lammers (D1BM00371B-(cit12)/*[position()=1]) 2016; 1
Ge (D1BM00371B-(cit40)/*[position()=1]) 2019; 43
Park (D1BM00371B-(cit4)/*[position()=1]) 2019; 9
Zhao (D1BM00371B-(cit20)/*[position()=1]) 2020; 16
Zuckerman (D1BM00371B-(cit1)/*[position()=1]) 2015; 14
Meel (D1BM00371B-(cit2)/*[position()=1]) 2019; 14
Deng (D1BM00371B-(cit32)/*[position()=1]) 2019; 19
Li (D1BM00371B-(cit42)/*[position()=1]) 2019; 10
Zheng (D1BM00371B-(cit43)/*[position()=1]) 2016; 28
Li (D1BM00371B-(cit24)/*[position()=1]) 2019; 13
Dai (D1BM00371B-(cit44)/*[position()=1]) 2017; 33
Gibson (D1BM00371B-(cit5)/*[position()=1]) 2019; 176
Shapira-Furman (D1BM00371B-(cit18)/*[position()=1]) 2019; 295
Gupta (D1BM00371B-(cit3)/*[position()=1]) 2017; 9
Yi (D1BM00371B-(cit15)/*[position()=1]) 2016; 238
Davis (D1BM00371B-(cit8)/*[position()=1]) 2010; 464
Shen (D1BM00371B-(cit13)/*[position()=1]) 2019; 197
Li (D1BM00371B-(cit6)/*[position()=1]) 2019; 190–191
Liao (D1BM00371B-(cit28)/*[position()=1]) 2020; 112
Zhen (D1BM00371B-(cit36)/*[position()=1]) 2018; 130
Zhou (D1BM00371B-(cit23)/*[position()=1]) 2016; 8
Mayer (D1BM00371B-(cit45)/*[position()=1]) 2015; 15
Roper (D1BM00371B-(cit46)/*[position()=1]) 2017; 111
Sellers (D1BM00371B-(cit9)/*[position()=1]) 2019; 13
Wang (D1BM00371B-(cit16)/*[position()=1]) 2016; 28
Zheng (D1BM00371B-(cit7)/*[position()=1]) 2018; 10
Zhou (D1BM00371B-(cit21)/*[position()=1]) 2017; 141
Chao (D1BM00371B-(cit19)/*[position()=1]) 2018; 2
He (D1BM00371B-(cit35)/*[position()=1]) 2021; 264
Zhang (D1BM00371B-(cit14)/*[position()=1]) 2020; 9
Song (D1BM00371B-(cit22)/*[position()=1]) 2020; 7
Wang (D1BM00371B-(cit17)/*[position()=1]) 2016; 104
Kong (D1BM00371B-(cit30)/*[position()=1]) 2020; 16
Lyu (D1BM00371B-(cit37)/*[position()=1]) 2018; 12
Xu (D1BM00371B-(cit48)/*[position()=1]) 2017; 9
Lee (D1BM00371B-(cit26)/*[position()=1]) 2016; 6
Shi (D1BM00371B-(cit38)/*[position()=1]) 2019; 19
Lu (D1BM00371B-(cit25)/*[position()=1]) 2019; 195
Das (D1BM00371B-(cit27)/*[position()=1]) 2019; 35
Sun (D1BM00371B-(cit34)/*[position()=1]) 2019; 362
References_xml – volume: 13
  start-page: 10961
  year: 2019
  ident: D1BM00371B-(cit9)/*[position()=1]
  publication-title: ACS Nano
  doi: 10.1021/acsnano.9b01515
  contributor:
    fullname: Sellers
– volume: 238
  start-page: 231
  year: 2016
  ident: D1BM00371B-(cit15)/*[position()=1]
  publication-title: J. Controlled Release
  doi: 10.1016/j.jconrel.2016.06.015
  contributor:
    fullname: Yi
– volume: 112
  start-page: 100666
  year: 2020
  ident: D1BM00371B-(cit28)/*[position()=1]
  publication-title: Prog. Mater. Sci.
  doi: 10.1016/j.pmatsci.2020.100666
  contributor:
    fullname: Liao
– volume: 130
  start-page: 3938
  year: 2018
  ident: D1BM00371B-(cit36)/*[position()=1]
  publication-title: Angew. Chem., Int. Ed.
  doi: 10.1002/anie.201712550
  contributor:
    fullname: Zhen
– volume: 7
  start-page: 723
  year: 2020
  ident: D1BM00371B-(cit22)/*[position()=1]
  publication-title: Natl. Sci. Rev.
  doi: 10.1093/nsr/nwz201
  contributor:
    fullname: Song
– volume: 464
  start-page: 1067
  year: 2010
  ident: D1BM00371B-(cit8)/*[position()=1]
  publication-title: Nature
  doi: 10.1038/nature08956
  contributor:
    fullname: Davis
– volume: 35
  start-page: 15320
  year: 2019
  ident: D1BM00371B-(cit27)/*[position()=1]
  publication-title: Langmuir
  doi: 10.1021/acs.langmuir.9b03001
  contributor:
    fullname: Das
– volume: 28
  start-page: 9320
  year: 2016
  ident: D1BM00371B-(cit29)/*[position()=1]
  publication-title: Adv. Mater.
  doi: 10.1002/adma.201602997
  contributor:
    fullname: Wang
– volume: 295
  start-page: 93
  year: 2019
  ident: D1BM00371B-(cit18)/*[position()=1]
  publication-title: J. Controlled Release
  doi: 10.1016/j.jconrel.2018.12.048
  contributor:
    fullname: Shapira-Furman
– volume: 30
  start-page: 1705980
  year: 2018
  ident: D1BM00371B-(cit39)/*[position()=1]
  publication-title: Adv. Mater.
  doi: 10.1002/adma.201705980
  contributor:
    fullname: Jiang
– volume: 14
  start-page: 1007
  year: 2019
  ident: D1BM00371B-(cit2)/*[position()=1]
  publication-title: Nat. Nanotechnol.
  doi: 10.1038/s41565-019-0567-y
  contributor:
    fullname: Meel
– volume: 13
  start-page: 3691
  year: 2019
  ident: D1BM00371B-(cit24)/*[position()=1]
  publication-title: ACS Nano
  doi: 10.1021/acsnano.9b00452
  contributor:
    fullname: Li
– volume: 141
  start-page: 116
  year: 2017
  ident: D1BM00371B-(cit21)/*[position()=1]
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2017.06.030
  contributor:
    fullname: Zhou
– volume: 8
  start-page: 29899
  year: 2016
  ident: D1BM00371B-(cit23)/*[position()=1]
  publication-title: ACS Appl. Mater. Interfaces
  doi: 10.1021/acsami.6b07838
  contributor:
    fullname: Zhou
– volume: 10
  start-page: 787
  year: 2018
  ident: D1BM00371B-(cit7)/*[position()=1]
  publication-title: Nat. Chem.
  doi: 10.1038/s41557-018-0055-2
  contributor:
    fullname: Zheng
– volume: 104
  start-page: 129
  year: 2016
  ident: D1BM00371B-(cit17)/*[position()=1]
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2016.07.013
  contributor:
    fullname: Wang
– volume: 14
  start-page: 843
  year: 2015
  ident: D1BM00371B-(cit1)/*[position()=1]
  publication-title: Nat. Rev. Drug Discovery
  doi: 10.1038/nrd4685
  contributor:
    fullname: Zuckerman
– volume: 2
  start-page: 611
  year: 2018
  ident: D1BM00371B-(cit19)/*[position()=1]
  publication-title: Nat. Biomed. Eng.
  doi: 10.1038/s41551-018-0262-6
  contributor:
    fullname: Chao
– volume: 43
  start-page: 8835
  year: 2019
  ident: D1BM00371B-(cit40)/*[position()=1]
  publication-title: New J. Chem.
  doi: 10.1039/C9NJ01402K
  contributor:
    fullname: Ge
– volume: 264
  start-page: 120453
  year: 2021
  ident: D1BM00371B-(cit35)/*[position()=1]
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2020.120453
  contributor:
    fullname: He
– volume: 195
  start-page: 13
  year: 2019
  ident: D1BM00371B-(cit25)/*[position()=1]
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2018.12.025
  contributor:
    fullname: Lu
– volume: 16
  start-page: 2004161
  year: 2020
  ident: D1BM00371B-(cit30)/*[position()=1]
  publication-title: Small
  doi: 10.1002/smll.202004161
  contributor:
    fullname: Kong
– volume: 19
  start-page: 6772
  year: 2019
  ident: D1BM00371B-(cit32)/*[position()=1]
  publication-title: Nano Lett.
  doi: 10.1021/acs.nanolett.9b01716
  contributor:
    fullname: Deng
– volume: 6
  start-page: 2196
  year: 2016
  ident: D1BM00371B-(cit26)/*[position()=1]
  publication-title: Theranostics
  doi: 10.7150/thno.16923
  contributor:
    fullname: Lee
– volume: 12
  start-page: 1801
  year: 2018
  ident: D1BM00371B-(cit37)/*[position()=1]
  publication-title: ACS Nano
  doi: 10.1021/acsnano.7b08616
  contributor:
    fullname: Lyu
– volume: 197
  start-page: 86
  year: 2019
  ident: D1BM00371B-(cit13)/*[position()=1]
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2019.01.019
  contributor:
    fullname: Shen
– volume: 414
  start-page: 57
  year: 2018
  ident: D1BM00371B-(cit10)/*[position()=1]
  publication-title: Cancer Lett.
  doi: 10.1016/j.canlet.2017.09.043
  contributor:
    fullname: Xu
– volume: 19
  start-page: 937
  year: 2019
  ident: D1BM00371B-(cit38)/*[position()=1]
  publication-title: Nano Lett.
  doi: 10.1021/acs.nanolett.8b04179
  contributor:
    fullname: Shi
– volume: 32
  start-page: 2002439
  year: 2020
  ident: D1BM00371B-(cit33)/*[position()=1]
  publication-title: Adv. Mater.
  doi: 10.1002/adma.202002439
  contributor:
    fullname: Dong
– volume: 9
  start-page: 8037
  year: 2019
  ident: D1BM00371B-(cit4)/*[position()=1]
  publication-title: Theranostics
  contributor:
    fullname: Park
– volume: 190–191
  start-page: 86
  year: 2019
  ident: D1BM00371B-(cit6)/*[position()=1]
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2018.10.046
  contributor:
    fullname: Li
– volume: 10
  start-page: 2774
  year: 2016
  ident: D1BM00371B-(cit31)/*[position()=1]
  publication-title: ACS Nano
  doi: 10.1021/acsnano.5b07882
  contributor:
    fullname: Yang
– volume: 28
  start-page: 8218
  year: 2016
  ident: D1BM00371B-(cit43)/*[position()=1]
  publication-title: Adv. Mater.
  doi: 10.1002/adma.201602486
  contributor:
    fullname: Zheng
– volume: 10
  start-page: 3349
  year: 2019
  ident: D1BM00371B-(cit42)/*[position()=1]
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-11269-8
  contributor:
    fullname: Li
– volume: 9
  start-page: 15
  year: 2017
  ident: D1BM00371B-(cit3)/*[position()=1]
  publication-title: Cancers
  doi: 10.3390/cancers9020015
  contributor:
    fullname: Gupta
– volume: 28
  start-page: 8912
  year: 2016
  ident: D1BM00371B-(cit16)/*[position()=1]
  publication-title: Adv. Mater.
  doi: 10.1002/adma.201506312
  contributor:
    fullname: Wang
– volume: 33
  start-page: 5378
  year: 2017
  ident: D1BM00371B-(cit44)/*[position()=1]
  publication-title: Langmuir
  doi: 10.1021/acs.langmuir.7b00097
  contributor:
    fullname: Dai
– volume: 362
  start-page: 679
  year: 2019
  ident: D1BM00371B-(cit34)/*[position()=1]
  publication-title: Chem. Eng. J.
  doi: 10.1016/j.cej.2019.01.095
  contributor:
    fullname: Sun
– volume: 16
  start-page: 2004879
  year: 2020
  ident: D1BM00371B-(cit20)/*[position()=1]
  publication-title: Small
  doi: 10.1002/smll.202004879
  contributor:
    fullname: Zhao
– volume: 154
  start-page: 248
  year: 2018
  ident: D1BM00371B-(cit47)/*[position()=1]
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2017.10.030
  contributor:
    fullname: Tang
– volume: 9
  start-page: 20361
  year: 2017
  ident: D1BM00371B-(cit48)/*[position()=1]
  publication-title: ACS Appl. Mater. Interfaces
  doi: 10.1021/acsami.7b02307
  contributor:
    fullname: Xu
– volume: 15
  start-page: 5427
  year: 2015
  ident: D1BM00371B-(cit45)/*[position()=1]
  publication-title: Nano Lett.
  doi: 10.1021/acs.nanolett.5b01833
  contributor:
    fullname: Mayer
– volume: 176
  start-page: 43
  year: 2019
  ident: D1BM00371B-(cit5)/*[position()=1]
  publication-title: Cell
  doi: 10.1016/j.cell.2018.10.049
  contributor:
    fullname: Gibson
– volume: 1
  start-page: 16014
  year: 2016
  ident: D1BM00371B-(cit11)/*[position()=1]
  publication-title: Nat. Rev. Mater.
  doi: 10.1038/natrevmats.2016.14
  contributor:
    fullname: Wilhelm
– volume: 243
  start-page: 119934
  year: 2020
  ident: D1BM00371B-(cit41)/*[position()=1]
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2020.119934
  contributor:
    fullname: Zhang
– volume: 9
  start-page: 1901101
  year: 2020
  ident: D1BM00371B-(cit14)/*[position()=1]
  publication-title: Adv. Healthcare Mater.
  doi: 10.1002/adhm.201901101
  contributor:
    fullname: Zhang
– volume: 111
  start-page: 3636
  year: 2017
  ident: D1BM00371B-(cit46)/*[position()=1]
  publication-title: J. Phys. Chem. C
  doi: 10.1021/jp064341w
  contributor:
    fullname: Roper
– volume: 1
  start-page: 16069
  year: 2016
  ident: D1BM00371B-(cit12)/*[position()=1]
  publication-title: Nat. Rev. Mater.
  doi: 10.1038/natrevmats.2016.69
  contributor:
    fullname: Lammers
SSID ssj0000779061
Score 2.347481
Snippet Local administration of therapeutic agents with long-term retention capabilities efficiently avoids nonspecific distribution in normal organs with an increased...
SourceID proquest
crossref
pubmed
rsc
SourceType Aggregation Database
Index Database
Publisher
StartPage 3516
SubjectTerms Ablation
Alginates
Animals
Biocompatibility
Calcium ions
Cell Line, Tumor
Chemical compounds
Chemotherapy
Doxorubicin
Gold
Hydrogels
Hyperthermia
Hyperthermia, Induced
Mice
Nanorods
Near infrared radiation
Neoplasms - therapy
Organs
Pharmacology
Silver
Tumors
Title Injectable hydrogel-mediated combination of hyperthermia ablation and photo-enhanced chemotherapy in the NIR-II window for tumor eradication
URI https://www.ncbi.nlm.nih.gov/pubmed/33949443
https://www.proquest.com/docview/2521529247
https://search.proquest.com/docview/2522398347
Volume 9
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELaW7QUOiFdhS0FGcKsCm9h5-NhCoYtoD2grVb1ETuw0K7EJSrOqljNHfjRjO4m96iIBlyiyrSTyfJkZj2c-I_SGEQACY8KLMiI8ygnzwG8mXpzkYVLQOIh0Ff_pWXRyTj9fhBej0U8na2nVZm_zH1vrSv5HqtAGclVVsv8g2eGh0AD3IF-4goTh-lcynlUqiqKLn8q1aOor-c3TpSDKjYQXwqrXeoSw4GyUt7dUZViZSYEzNAFl3daerEqTDABSXHZlWeshC3L21ZvNDm5gAV_fmMzE1VJxhTdcdEG_jd3hRQ2OsJmBg87G2si90S6feGcz3aj1mc0b4jqGe7lYbxt3WcrqquQLN2YR-DpDkFrVFih-CJp0OzLSbTMEpr1uZg4EmaNnSehHjs1WnK5b7cGUKDpV4WdLzU2YWas35CLazjtoJwB1lYzRzuHxfPZliNVNFSmjpt4dPrxnuiXsnX3Apm9za8EC7kvTHyuj3Zf5A3S_W3fgQwOih2gkq0fonsNG-Rj9snDCt-CEHTjhusAunHAPJwxwwptwwi6c8KLCcIsNnLCBEwY4YQ0n7MDpCTr_eDx_f-J1h3V4OSFx64WMRzIsQhFnGQs5_P8kU4eVgZfkx5n0we-HiZKBoFz4sgjUMQmChrQACyCDxCe7aFzVlXyGsABl4RdsynNGKQtyPiVCFHGuNrULzsIJet1Pc_rdcLKkOpeCsPSDf3SqhXE0Qfu9BNLun71Og1Cd48wCGk_Qq6EbNKraJuOVrFd6jCLFJGrMUyO54TWEMAofRSZoF0Q5NFsI7P2p4zm6a_-EfTRum5V8Af5sm73s4PYbniGkzA
link.rule.ids 315,783,787,27938,27939
linkProvider Royal Society of Chemistry
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Injectable+hydrogel-mediated+combination+of+hyperthermia+ablation+and+photo-enhanced+chemotherapy+in+the+NIR-II+window+for+tumor+eradication&rft.jtitle=Biomaterials+science&rft.au=Wang%2C+Gang&rft.au=Zhang%2C+Na&rft.au=Cao%2C+Ziyang&rft.au=Zhang%2C+Zhenghai&rft.date=2021-05-04&rft.issn=2047-4830&rft.eissn=2047-4849&rft.volume=9&rft.issue=9&rft.spage=3516&rft.epage=3525&rft_id=info:doi/10.1039%2Fd1bm00371b&rft.externalDocID=d1bm00371b
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2047-4830&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2047-4830&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2047-4830&client=summon