Thymic Hyperplasia Associated with Graves' Disease: Pathophysiology and Proposed Management Algorithm

• Published in: Thyroid (New York, N.Y.) Vol. 27; no. 8; p. 994
• Main Authors: Haider, Uzma, Richards, Patrick, Gianoukakis, Andrew G
• Format: Journal Article
• Language: English
• Published: United States 01.08.2017
• Subjects: Animals; Autoimmunity; Combined Modality Therapy - adverse effects; Conservative Treatment - adverse effects; Decision Trees; Diagnosis, Differential; Graves Disease - immunology; Graves Disease - pathology; Graves Disease - physiopathology; Graves Disease - therapy; Humans; Incidental Findings; Models, Biological; Organ Size; Practice Guidelines as Topic; Precision Medicine; Thymus Gland - diagnostic imaging; Thymus Gland - immunology; Thymus Gland - pathology; Thymus Gland - physiopathology; Thymus Hyperplasia - diagnosis; Thymus Hyperplasia - etiology; Thymus Hyperplasia - pathology; Thymus Hyperplasia - prevention & control; hyperplasia; thymic lymphoid hyperplasia; autoimmune; true thymic hyperplasia; Graves’ disease; thymic

The association between Graves' disease (GD) and thymic hyperplasia (TH) was first described in 1912 and has been reported numerous times thereafter. TH associated with GD presents as an incidental mediastinal mass on chest X-ray or computed tomography (CT). The pathogenesis of TH in the settin...