Optical analysis of Müller glia cells as light transporters through the retina

One and half decades ago, Müller glia cells of the retina became subjects of extended research as optical waveguides. It was demonstrated that outside the fovea, these cells are capable of providing light transmission through the thicker parts of the retina from the vitreous surface to the photorece...

Full description

Saved in:
Bibliographic Details
Published inBiomedical optics express Vol. 13; no. 12; pp. 6335 - 6356
Main Authors Szabó, Levente, Erdei, Gábor, Maák, Pál Andor
Format Journal Article
LanguageEnglish
Published United States Optica Publishing Group 01.12.2022
Online AccessGet full text
ISSN2156-7085
2156-7085
DOI10.1364/BOE.462568

Cover

Abstract One and half decades ago, Müller glia cells of the retina became subjects of extended research as optical waveguides. It was demonstrated that outside the fovea, these cells are capable of providing light transmission through the thicker parts of the retina from the vitreous surface to the photoreceptor cells. We combined optical modeling of the eye’s optical system with numerical methods that describe light guiding within Müller cells to analyze efficiency of light capture and guidance at different peripheral positions. We show that higher order guided modes play an important role, especially in the case of higher incidence angles and extended geometry of the electromagnetic field distributions predicted by the eye’s optical model. We analyze the mode structure excited at different retinal peripheral positions and show that actual construction of these cells optimizes light guiding. Our results refine previously published modeling results regarding Müller cells as waveguides and provide extension to the whole area of the retina.
AbstractList One and half decades ago, Müller glia cells of the retina became subjects of extended research as optical waveguides. It was demonstrated that outside the fovea, these cells are capable of providing light transmission through the thicker parts of the retina from the vitreous surface to the photoreceptor cells. We combined optical modeling of the eye's optical system with numerical methods that describe light guiding within Müller cells to analyze efficiency of light capture and guidance at different peripheral positions. We show that higher order guided modes play an important role, especially in the case of higher incidence angles and extended geometry of the electromagnetic field distributions predicted by the eye's optical model. We analyze the mode structure excited at different retinal peripheral positions and show that actual construction of these cells optimizes light guiding. Our results refine previously published modeling results regarding Müller cells as waveguides and provide extension to the whole area of the retina.One and half decades ago, Müller glia cells of the retina became subjects of extended research as optical waveguides. It was demonstrated that outside the fovea, these cells are capable of providing light transmission through the thicker parts of the retina from the vitreous surface to the photoreceptor cells. We combined optical modeling of the eye's optical system with numerical methods that describe light guiding within Müller cells to analyze efficiency of light capture and guidance at different peripheral positions. We show that higher order guided modes play an important role, especially in the case of higher incidence angles and extended geometry of the electromagnetic field distributions predicted by the eye's optical model. We analyze the mode structure excited at different retinal peripheral positions and show that actual construction of these cells optimizes light guiding. Our results refine previously published modeling results regarding Müller cells as waveguides and provide extension to the whole area of the retina.
One and half decades ago, Müller glia cells of the retina became subjects of extended research as optical waveguides. It was demonstrated that outside the fovea, these cells are capable of providing light transmission through the thicker parts of the retina from the vitreous surface to the photoreceptor cells. We combined optical modeling of the eye’s optical system with numerical methods that describe light guiding within Müller cells to analyze efficiency of light capture and guidance at different peripheral positions. We show that higher order guided modes play an important role, especially in the case of higher incidence angles and extended geometry of the electromagnetic field distributions predicted by the eye’s optical model. We analyze the mode structure excited at different retinal peripheral positions and show that actual construction of these cells optimizes light guiding. Our results refine previously published modeling results regarding Müller cells as waveguides and provide extension to the whole area of the retina.
Author Szabó, Levente
Erdei, Gábor
Maák, Pál Andor
Author_xml – sequence: 1
  givenname: Levente
  surname: Szabó
  fullname: Szabó, Levente
– sequence: 2
  givenname: Gábor
  orcidid: 0000-0003-1584-3142
  surname: Erdei
  fullname: Erdei, Gábor
– sequence: 3
  givenname: Pál Andor
  surname: Maák
  fullname: Maák, Pál Andor
BackLink https://www.ncbi.nlm.nih.gov/pubmed/36589561$$D View this record in MEDLINE/PubMed
BookMark eNpVUU1LAzEQDVKxtfbiD5AcRWjdbL52L4KW-gGVXvQcZrfZNpJuarIr9L9584-Z0lrqXObBPN6bmXeOOrWrNUKXJBkRKtjtw2wyYiLlIjtBvZRwMZRJxjtHuIsGIXwksRiTCc3OUJcKnuVckB6azdaNKcFiqMFuggnYVfj159ta7fHCGsCltjZgCNiaxbLBjYc6rJ1vtA-4WXrXLpaxa-x1Y2q4QKcV2KAH-95H74-Tt_HzcDp7ehnfT4clpbIZMqFplQtWlZRAxXKeszmXnNJCAjDG0ogKKLVOyFzMSxAVYTxLipzKDFIOtI_udrrrtljpeanruJhVa29W4DfKgVH_J7VZqoX7UrmULMtIFLjeC3j32erQqJUJ21uh1q4NKpUiISKPX4zUq2Ovg8nfFyPhZkcovQvB6-pAIYnapqRiSmqXEv0FvWqFaA
Cites_doi 10.1016/j.bpj.2011.09.062
10.1364/JOSAA.14.001684
10.1177/0301006616657097
10.1002/glia.23727
10.1073/pnas.0611180104
10.1016/j.visres.2009.07.001
10.1364/JOSA.43.000495
10.1038/ncomms12172
10.1364/OE.420493
10.1002/(SICI)1098-1136(199704)19:4<311::AID-GLIA4>3.0.CO;2-#
10.1364/OE.22.032208
10.1016/1350-9462(95)00008-9
10.1038/nn.2465
10.1002/glia.22477
10.1038/s41598-019-44160-z
10.1037/h0083168
10.1038/ncomms5319
10.1364/JOSAA.4.001524
10.1038/scientificamerican0661-72
10.1103/PhysRevLett.104.158102
10.1364/OE.23.023436
10.1016/j.preteyeres.2018.03.006
10.1001/archopht.1968.00980050005002
10.1038/nrn2283
ContentType Journal Article
Copyright 2022 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement.
2022 Optica Publishing Group under the terms of the 2022 Optica Publishing Group
Copyright_xml – notice: 2022 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement.
– notice: 2022 Optica Publishing Group under the terms of the 2022 Optica Publishing Group
DBID AAYXX
CITATION
NPM
7X8
5PM
DOI 10.1364/BOE.462568
DatabaseName CrossRef
PubMed
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
PubMed
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic

PubMed
CrossRef
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Engineering
EISSN 2156-7085
EndPage 6356
ExternalDocumentID PMC9774881
36589561
10_1364_BOE_462568
Genre Journal Article
GrantInformation_xml – fundername: European Commission
  grantid: 862721
– fundername: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal
  grantid: NBP 24 (ED-17-1-2017-0011); NKFIH-873-4/2020; VKSZ-12-1-2013-80
GroupedDBID 4.4
53G
8SL
AAFWJ
AAWJZ
AAYXX
ADBBV
AEDJG
AENEX
AFPKN
AKGWG
ALMA_UNASSIGNED_HOLDINGS
AOIJS
ATHME
AYPRP
AZSQR
AZYMN
BAWUL
BCNDV
CITATION
DIK
DSZJF
E3Z
EBS
GROUPED_DOAJ
GX1
HYE
KQ8
LPK
M~E
O5R
O5S
OFLFD
OK1
OPJBK
ROL
ROS
RPM
TR6
NPM
ROP
7X8
5PM
ID FETCH-LOGICAL-c337t-46e3f964fc31af49594d57533b7aa444233bbacee01d6dca6f14580b9378a25a3
ISSN 2156-7085
IngestDate Thu Aug 21 18:40:20 EDT 2025
Thu Jul 10 17:11:11 EDT 2025
Wed Feb 19 02:24:49 EST 2025
Tue Jul 01 01:36:36 EDT 2025
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 12
Language English
License 2022 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement.
https://doi.org/10.1364/OA_License_v2#VOR-OA
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c337t-46e3f964fc31af49594d57533b7aa444233bbacee01d6dca6f14580b9378a25a3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ORCID 0000-0003-1584-3142
OpenAccessLink https://doi.org/10.1364/boe.462568
PMID 36589561
PQID 2760169215
PQPubID 23479
PageCount 22
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_9774881
proquest_miscellaneous_2760169215
pubmed_primary_36589561
crossref_primary_10_1364_BOE_462568
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2022-12-01
PublicationDateYYYYMMDD 2022-12-01
PublicationDate_xml – month: 12
  year: 2022
  text: 2022-12-01
  day: 01
PublicationDecade 2020
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle Biomedical optics express
PublicationTitleAlternate Biomed Opt Express
PublicationYear 2022
Publisher Optica Publishing Group
Publisher_xml – name: Optica Publishing Group
References Reichenbach (boe-13-12-6335-R18) 2013; 61
Reichenbach (boe-13-12-6335-R4) 1995; 15
Riggs (boe-13-12-6335-R10) 1953; 43
Bringmann (boe-13-12-6335-R14) 1997; 19
Straatsma (boe-13-12-6335-R28) 1968; 80
Franze (boe-13-12-6335-R3) 2007; 104
Fülep (boe-13-12-6335-R23) 2019; 9
Veettikazhy (boe-13-12-6335-R20) 2021; 29
Liou (boe-13-12-6335-R24) 1997; 14
Labin (boe-13-12-6335-R17) 2014; 22
Reichenbach (boe-13-12-6335-R19) 2020; 68
Kusnyerik (boe-13-12-6335-R22) 2015; 23
Rossi (boe-13-12-6335-R32) 2010; 13
Colakoglu (boe-13-12-6335-R21) 2017; 10
Atchinson (boe-13-12-6335-R27) 2002
Denton (boe-13-12-6335-R7) 1999; 19
Chernick (boe-13-12-6335-R33) 2011
Tinsley (boe-13-12-6335-R9) 2016; 7
Kröger (boe-13-12-6335-R6) 2009; 49
Pritchard (boe-13-12-6335-R13) 1960; 14
Gegenfurtner (boe-13-12-6335-R11) 2016; 45
Labin (boe-13-12-6335-R16) 2014; 5
Thibos (boe-13-12-6335-R31) 1987; 4
Agte (boe-13-12-6335-R15) 2011; 101
Bringmann (boe-13-12-6335-R5) 2018; 66
Reichenbach (boe-13-12-6335-R2) 2012; 2012
Lamb (boe-13-12-6335-R8) 2007; 8
Labin (boe-13-12-6335-R1) 2010; 104
Pritchard (boe-13-12-6335-R12) 1961; 204
References_xml – volume: 101
  start-page: 2611
  year: 2011
  ident: boe-13-12-6335-R15
  publication-title: Biophys. J.
  doi: 10.1016/j.bpj.2011.09.062
– volume: 14
  start-page: 1684
  year: 1997
  ident: boe-13-12-6335-R24
  publication-title: J. Opt. Soc. Am. A
  doi: 10.1364/JOSAA.14.001684
– volume: 10
  start-page: 1759
  year: 2017
  ident: boe-13-12-6335-R21
  publication-title: Int. J. Ophthalmol.
– year: 2002
  ident: boe-13-12-6335-R27
– volume: 45
  start-page: 1333
  year: 2016
  ident: boe-13-12-6335-R11
  publication-title: Perception
  doi: 10.1177/0301006616657097
– volume: 68
  start-page: 768
  year: 2020
  ident: boe-13-12-6335-R19
  publication-title: Glia
  doi: 10.1002/glia.23727
– volume: 104
  start-page: 8287
  year: 2007
  ident: boe-13-12-6335-R3
  publication-title: Proc. Natl. Acad. Sci. U.S.A.
  doi: 10.1073/pnas.0611180104
– volume: 49
  start-page: 2318
  year: 2009
  ident: boe-13-12-6335-R6
  publication-title: Vision Res.
  doi: 10.1016/j.visres.2009.07.001
– volume: 43
  start-page: 495
  year: 1953
  ident: boe-13-12-6335-R10
  publication-title: J. Opt. Soc. Am.
  doi: 10.1364/JOSA.43.000495
– volume: 7
  start-page: 12172
  year: 2016
  ident: boe-13-12-6335-R9
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms12172
– volume: 19
  start-page: 37
  year: 1999
  ident: boe-13-12-6335-R7
  publication-title: Origins & Design
– year: 2011
  ident: boe-13-12-6335-R33
– volume: 29
  start-page: 11819
  year: 2021
  ident: boe-13-12-6335-R20
  publication-title: Opt. Express
  doi: 10.1364/OE.420493
– volume: 19
  start-page: 311
  year: 1997
  ident: boe-13-12-6335-R14
  publication-title: Glia
  doi: 10.1002/(SICI)1098-1136(199704)19:4<311::AID-GLIA4>3.0.CO;2-#
– volume: 22
  start-page: 32208
  year: 2014
  ident: boe-13-12-6335-R17
  publication-title: Opt. Express
  doi: 10.1364/OE.22.032208
– volume: 15
  start-page: 139
  year: 1995
  ident: boe-13-12-6335-R4
  publication-title: Prog. Retinal Eye Res.
  doi: 10.1016/1350-9462(95)00008-9
– volume: 13
  start-page: 156
  year: 2010
  ident: boe-13-12-6335-R32
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.2465
– volume: 61
  start-page: 651
  year: 2013
  ident: boe-13-12-6335-R18
  publication-title: Glia
  doi: 10.1002/glia.22477
– volume: 9
  start-page: 7805
  year: 2019
  ident: boe-13-12-6335-R23
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-019-44160-z
– volume: 14
  start-page: 67
  year: 1960
  ident: boe-13-12-6335-R13
  publication-title: Canadian Journal of Psychology/Revue canadienne de psychologie
  doi: 10.1037/h0083168
– volume: 5
  start-page: 4319
  year: 2014
  ident: boe-13-12-6335-R16
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms5319
– volume: 2012
  start-page: 247
  year: 2012
  ident: boe-13-12-6335-R2
  publication-title: Selected Topics on Optical Fiber Technology, IntechOpen
– volume: 4
  start-page: 1524
  year: 1987
  ident: boe-13-12-6335-R31
  publication-title: J. Opt. Soc. Am. A
  doi: 10.1364/JOSAA.4.001524
– volume: 204
  start-page: 72
  year: 1961
  ident: boe-13-12-6335-R12
  publication-title: Sci. Am.
  doi: 10.1038/scientificamerican0661-72
– volume: 104
  start-page: 158102
  year: 2010
  ident: boe-13-12-6335-R1
  publication-title: Phys. Rev. Lett.
  doi: 10.1103/PhysRevLett.104.158102
– volume: 23
  start-page: 23436
  year: 2015
  ident: boe-13-12-6335-R22
  publication-title: Opt. Express
  doi: 10.1364/OE.23.023436
– volume: 66
  start-page: 49
  year: 2018
  ident: boe-13-12-6335-R5
  publication-title: Prog. Retinal Eye Res.
  doi: 10.1016/j.preteyeres.2018.03.006
– volume: 80
  start-page: 3
  year: 1968
  ident: boe-13-12-6335-R28
  publication-title: Arch. Ophthalmol.
  doi: 10.1001/archopht.1968.00980050005002
– volume: 8
  start-page: 960
  year: 2007
  ident: boe-13-12-6335-R8
  publication-title: Nat. Rev. Neurosci.
  doi: 10.1038/nrn2283
SSID ssj0000447038
Score 2.322246
Snippet One and half decades ago, Müller glia cells of the retina became subjects of extended research as optical waveguides. It was demonstrated that outside the...
SourceID pubmedcentral
proquest
pubmed
crossref
SourceType Open Access Repository
Aggregation Database
Index Database
StartPage 6335
Title Optical analysis of Müller glia cells as light transporters through the retina
URI https://www.ncbi.nlm.nih.gov/pubmed/36589561
https://www.proquest.com/docview/2760169215
https://pubmed.ncbi.nlm.nih.gov/PMC9774881
Volume 13
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9swDBayDhi2w7B1r-xRaNhuhTPLkmX7uBVpi6JudkiA3AwplrsCgR0kDlD0t_W2PzbqYcdee-h2cQzFkBzxC0FS5EeEvuZJLqlQ1CtiHbop5MITpGBgyLGCcZ4nca6rkdMLfjpjZ_NwPhicdbKWtrUcLW7urSv5H6nCGMhVV8n-g2TbSWEA7kG-cAUJw_VBMp6salfsv2MWSfXR948jXeF3eLm8Eoc6NL_R7WSW2g_XPSEcm_l603bpMXmGuvhZ9A55TWm-WaFaGTpndb1qUzZ0WOZGSLMcNe69IYNqgTJe58qkCpyYw3giqzYPOBV2yGjin_Z-qXMr3SMuChEEnYwOo6zAcuBe5Nv2OyN1z1ijbWkXVUFHd3JqiUvuKHXKmU5Vn4xHDLw124Wnz5x9McmOZ-fn2XQ8nz5CjwNwGbSSPpmTNt7mMwbKzTQobF7LsdXC9N92k_ftkztOx9-5sx1jZPoCPXdeBP5uIfESDVS5j551uCX30ZPUZU28QhOHE9zgBFcFTn_faoxgjRFsMILFBhuM4C5GsMMIfCpsMfIazY7H06NTzzXS8BaURrXHuKJFwlmxoEQU4BInLAcznVIZCcEYWNRUSgHmkk9yni8ELwgLY1-C6RqLIBT0Ddorq1K9Q1iEQskoJvAsZRTc5ThWofLhP00SJQUZoi_N9mUry5eSmUNTzjLY5Mxu8hB9bnY2A3Wmf6QoVbXdZEFk-IFARkP01u50Ow8Fa1nXYQ9R1JNB-4CmSu9_U179MpTp2suJY_L-Aet-QE93AP-I9ur1Vn0Cw7OWByZgc2Bw9Qeg74Rp
linkProvider Geneva Foundation for Medical Education and Research
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Optical+analysis+of+M%C3%BCller+glia+cells+as+light+transporters+through+the+retina&rft.jtitle=Biomedical+optics+express&rft.au=Szab%C3%B3%2C+Levente&rft.au=Erdei%2C+G%C3%A1bor&rft.au=Ma%C3%A1k%2C+P%C3%A1l+Andor&rft.date=2022-12-01&rft.issn=2156-7085&rft.eissn=2156-7085&rft.volume=13&rft.issue=12&rft.spage=6335&rft_id=info:doi/10.1364%2FBOE.462568&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2156-7085&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2156-7085&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2156-7085&client=summon