Increased Expression of TXNIP Facilitates Oxidative Stress in Nasal Epithelial Cells of Patients With Chronic Rhinosinusitis With Nasal Polyps

• Published in: American journal of rhinology & allergy Vol. 35; no. 5; p. 607
• Main Authors: Lin, Hai, Ba, Guangyi, Tang, Ru, Li, Mingxian, Li, Zhipeng, Li, Dawei, Ye, Haibo, Zhang, Weitian
• Format: Journal Article
• Language: English
• Published: United States 01.09.2021
• Subjects: Carrier Proteins - genetics; Chronic Disease; Epithelial Cells; Humans; Nasal Polyps; Oxidative Stress; Rhinitis; Sinusitis; human nasal epithelial cells; thioredoxin; superoxide dismutase; reactive oxygen species; chronic rhinosinusitis; inflammatory disease; thioredoxin-interacting protein; malondialdehyde; nasal polyp; oxidative stress

Oxidative stress plays crucial roles in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP). Thioredoxin-interacting protein (TXNIP) is essential in the process of triggering oxidative stress. However, its role and mechanism in CRSwNP remain unclear. The present study sought to exp...