Hollow Gold Nanoparticles Loaded with L-Buthionine-Sulfoximine as a Novel Nanomedicine for In Vitro Cancer Cell Therapy

A novel nanomedicine, constructed by simultaneously binding L-buthionine-sulfoximine (BSO) and thiolated polyethylene glycol (PEG) to the surface of 100 nm hollow gold nanoparticles (HAuNS), was expected to be used in effective therapeutics of cancer. The current study is aimed at evaluating in vitr...

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Published inJournal of nanomaterials Vol. 2021; pp. 1 - 9
Main Authors Liu, Min, Li, Wushan, Xu, Ri, Jiang, Xiaoyan, Liu, Anchang
Format Journal Article
LanguageEnglish
Published New York Hindawi 18.08.2021
Hindawi Limited
Subjects
Acids
Anticancer properties
Apoptosis
Cancer therapies
Chemotherapy
Cytotoxicity
Flow cytometry
Gold
Lung cancer
Nanomaterials
Nanoparticles
Necrosis
Polyethylene glycol
Toxicity
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Abstract A novel nanomedicine, constructed by simultaneously binding L-buthionine-sulfoximine (BSO) and thiolated polyethylene glycol (PEG) to the surface of 100 nm hollow gold nanoparticles (HAuNS), was expected to be used in effective therapeutics of cancer. The current study is aimed at evaluating in vitro the antitumor efficacy of newly synthesized BSO-loaded PEG-SH-HAuNS (BSO@HAuNS) with strong resonances in near-infrared (NIR) as a chemotherapy agents against a line of human lung cancer cells (A549). Here, we conducted cytotoxicity assays and found BSO@HAuNS to efficiently kill human lung cancer cells by ROS generation, indicating that BSO facilitated an increased susceptibility of cancer cells to PEG-SH-HAuNS. Based on flow cytometry analysis, BSO@HAuNS can induce apoptosis and necrosis in mitochondrial-dependent pathway in A549 cells. Our results revealed a novel class of nanomedicine with high potential to be implemented as effective chemotherapy agents for patients diagnosed with unresectable lung cancer.
AbstractList A novel nanomedicine, constructed by simultaneously binding L-buthionine-sulfoximine (BSO) and thiolated polyethylene glycol (PEG) to the surface of 100 nm hollow gold nanoparticles (HAuNS), was expected to be used in effective therapeutics of cancer. The current study is aimed at evaluating in vitro the antitumor efficacy of newly synthesized BSO-loaded PEG-SH-HAuNS (BSO@HAuNS) with strong resonances in near-infrared (NIR) as a chemotherapy agents against a line of human lung cancer cells (A549). Here, we conducted cytotoxicity assays and found BSO@HAuNS to efficiently kill human lung cancer cells by ROS generation, indicating that BSO facilitated an increased susceptibility of cancer cells to PEG-SH-HAuNS. Based on flow cytometry analysis, BSO@HAuNS can induce apoptosis and necrosis in mitochondrial-dependent pathway in A549 cells. Our results revealed a novel class of nanomedicine with high potential to be implemented as effective chemotherapy agents for patients diagnosed with unresectable lung cancer.
Author Jiang, Xiaoyan
Liu, Min
Liu, Anchang
Li, Wushan
Xu, Ri
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CitedBy_id crossref_primary_10_1016_j_colsurfa_2023_131972
crossref_primary_10_1080_10937404_2023_2246876
crossref_primary_10_1186_s12951_022_01626_z
Cites_doi 10.1016/j.nano.2018.05.016
10.1016/j.ijrobp.2015.07.2275
10.1016/j.jconrel.2016.11.021
10.3390/ijms18010120
10.1007/s12272-019-01179-0
10.1021/nn500152u
10.1016/j.tox.2021.152762
10.1016/j.ceca.2011.04.007
10.1021/ja401612x
10.1158/1078-0432.CCR-10-0978
10.1016/j.carbpol.2021.117659
10.1016/j.jconrel.2018.06.031
10.7314/APJCP.2012.13.4.1617
10.1016/j.nano.2012.05.016
10.1038/s41419-018-0794-4
10.1016/j.jinorgbio.2013.10.021
10.1016/j.biomaterials.2011.09.064
10.1021/acs.molpharmaceut.8b00810
10.31661/jbpe.v0i0.579
10.1186/1743-8977-11-26
10.1615/CritRevTherDrugCarrierSyst.2017017845
10.3109/15376516.2013.869783
10.1021/acs.langmuir.9b02420
10.2147/IJN.S295809
10.1007/s11051-010-9911-8
10.1038/s41565-019-0373-6
10.1186/s12951-018-0362-1
10.1007/s11051-013-1745-8
10.1007/s11033-019-04897-2
10.1186/s12951-019-0532-9
10.1002/ijc.31937
10.2174/0929867326666190506123721
10.1002/smll.201401360
10.1016/j.biomaterials.2011.10.058
10.1016/j.ijpharm.2016.04.042
10.3109/1061186X.2015.1051049
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Copyright Copyright © 2021 Min Liu et al.
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Y. L. Wang (26) 2018; 23
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10
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11
33
12
34
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  doi: 10.1016/j.nano.2018.05.016
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  doi: 10.1016/j.ijrobp.2015.07.2275
– ident: 11
  doi: 10.1016/j.jconrel.2016.11.021
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  doi: 10.3390/ijms18010120
– ident: 22
  doi: 10.1007/s12272-019-01179-0
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  doi: 10.1021/nn500152u
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  doi: 10.1016/j.tox.2021.152762
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  doi: 10.1016/j.ceca.2011.04.007
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  doi: 10.1021/ja401612x
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  doi: 10.1158/1078-0432.CCR-10-0978
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  doi: 10.1016/j.carbpol.2021.117659
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  doi: 10.1016/j.jconrel.2018.06.031
– volume: 23
  start-page: 752
  issue: 3
  year: 2018
  ident: 26
  article-title: Antiproliferative activity of Farnesol in HeLa cervical cancer cells is mediated via apoptosis induction, loss of mitochondrial membrane potential (lambdapsim) and PI3K/Akt signalling pathway
  publication-title: Journal of the Balkan Union of Oncology
  contributor:
    fullname: Y. L. Wang
– ident: 32
  doi: 10.7314/APJCP.2012.13.4.1617
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  doi: 10.1016/j.nano.2012.05.016
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  doi: 10.1038/s41419-018-0794-4
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  doi: 10.1016/j.jinorgbio.2013.10.021
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  doi: 10.1016/j.biomaterials.2011.09.064
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  doi: 10.1021/acs.molpharmaceut.8b00810
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  doi: 10.31661/jbpe.v0i0.579
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  doi: 10.1186/1743-8977-11-26
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  doi: 10.1615/CritRevTherDrugCarrierSyst.2017017845
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  doi: 10.1021/acs.langmuir.9b02420
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  doi: 10.2147/IJN.S295809
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  doi: 10.1007/s11051-010-9911-8
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  doi: 10.1038/s41565-019-0373-6
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  doi: 10.1186/s12951-018-0362-1
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  doi: 10.1007/s11051-013-1745-8
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  doi: 10.1007/s11033-019-04897-2
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  doi: 10.1186/s12951-019-0532-9
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  doi: 10.1002/ijc.31937
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  doi: 10.2174/0929867326666190506123721
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  doi: 10.1002/smll.201401360
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  doi: 10.1016/j.biomaterials.2011.10.058
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  doi: 10.1016/j.ijpharm.2016.04.042
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SubjectTerms Acids
Anticancer properties
Apoptosis
Cancer therapies
Chemotherapy
Cytotoxicity
Flow cytometry
Gold
Lung cancer
Nanomaterials
Nanoparticles
Necrosis
Polyethylene glycol
Toxicity
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Title Hollow Gold Nanoparticles Loaded with L-Buthionine-Sulfoximine as a Novel Nanomedicine for In Vitro Cancer Cell Therapy
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