Molecular and clinical features of the TP53 signature gene expression profile in early-stage breast cancer

• Published in: Oncotarget Vol. 9; no. 18; pp. 14193 - 14206
• Main Authors: Yamaguchi, Shigeo, Takahashi, Shin, Mogushi, Kaoru, Izumi, Yuki, Nozaki, Yumi, Nomizu, Tadashi, Kakugawa, Yoichiro, Ishida, Takanori, Ohuchi, Noriaki, Ishioka, Chikashi, Kato, Shunsuke
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 06.03.2018
• Subjects: Research Paper; breast cancer; prognostic biomarker; genomic instability; TP53; transcriptome

signature has a robust predictive performance for prognosis in early-stage breast cancer, but the experiment that reported this relied on public microarray data and fresh-frozen samples. Before signature can be used in a clinical setting, a simple and low-cost diagnostic system using formalin-fixed...