Dipeptidyl Peptidase-4 Stabilizes Integrin α4β1 Complex to Promote Thyroid Cancer Cell Metastasis by Activating Transforming Growth Factor-Beta Signaling Pathway

• Published in: Thyroid (New York, N.Y.) Vol. 32; no. 11; p. 1411
• Main Authors: He, Qingyuan, Cao, Hongxin, Zhao, Yuelei, Chen, Pu, Wang, Na, Li, Wenyuan, Cui, Rongrong, Hou, Peng, Zhang, Xiaozhi, Ji, Meiju
• Format: Journal Article
• Language: English
• Published: United States 01.11.2022
• Subjects: Animals; Cell Line, Tumor; Cell Movement; Dipeptidyl Peptidase 4 - genetics; Dipeptidyl Peptidase 4 - metabolism; Dipeptidyl Peptidase 4 - pharmacology; Dipeptidyl-Peptidase IV Inhibitors - pharmacology; Epithelial-Mesenchymal Transition; Integrin alpha4beta1; Mice; Proto-Oncogene Proteins c-akt - metabolism; Signal Transduction; Sitagliptin Phosphate - pharmacology; Thyroid Neoplasms - genetics; Thyroid Neoplasms - metabolism; Transforming Growth Factor beta1 - metabolism; Transforming Growth Factor beta1 - pharmacology; Transforming Growth Factors - pharmacology; DPP4; integrins; thyroid cancer; tumor metastasis; TGF-β signaling

Metastatic disease is a major cause of thyroid cancer-related death. However, the mechanisms responsible for thyroid cancer metastasis are unclear. Dipeptidyl peptidase-4 (DPP4) is a multifunctional cell surface glycoprotein that has been reported to be a negative prognostic factor in thyroid cancer...