An early and late cytotoxicity evaluation of lidocaine on human oral mucosa fibroblasts

• Published in: Experimental biology and medicine (Maywood, N.J.) Vol. 239; no. 1; p. 71
• Main Authors: Oliveira, Ana Celeste, Rodríguez, Ismael Ángel, Garzón, Ingrid, Martín-Piedra, Miguel Ángel, Alfonso-Rodríguez, Camilo Andrés, García, José Manuel, Sánchez-Quevedo, María del Carmen, Alaminos, Miguel
• Format: Journal Article
• Language: English
• Published: England 01.01.2014
• Subjects: Anesthetics, Local - adverse effects; Anesthetics, Local - pharmacology; Apoptosis - drug effects; Cell Survival - drug effects; Cells, Cultured; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical - methods; Female; Fibroblasts - metabolism; Fibroblasts - pathology; Humans; Lidocaine - adverse effects; Lidocaine - pharmacology; Male; Middle Aged; Mouth Mucosa - metabolism; Mouth Mucosa - pathology; calcein ethidium; X-ray microanalysis; Lidocaine; MTT; WST-1; human oral mucosa fibroblasts

Local anesthetic drugs are extensively used in dentistry. However, the cytotoxic effects of these pharmaceutical compounds remain unclear. In this work, we have evaluated the cell viability and cell function of human oral mucosa fibroblasts exposed to different concentrations of lidocaine for increa...