Mesenchymal stem cells secrete immunologically active exosomes

• Published in: Stem cells and development Vol. 23; no. 11; p. 1233
• Main Authors: Zhang, Bin, Yin, Yijun, Lai, Ruenn Chai, Tan, Soon Sim, Choo, Andre Boon Hwa, Lim, Sai Kiang
• Format: Journal Article
• Language: English
• Published: United States 01.06.2014
• Subjects: Animals; Cell Differentiation - immunology; Cells, Cultured; Exosomes - immunology; Exosomes - metabolism; HEK293 Cells; Humans; Immunity - physiology; Mesenchymal Stromal Cells - immunology; Mesenchymal Stromal Cells - secretion; Mice; Mice, Inbred BALB C; Myeloid Differentiation Factor 88 - physiology; Signal Transduction; T-Lymphocytes, Regulatory - immunology; T-Lymphocytes, Regulatory - metabolism; Toll-Like Receptors - physiology

Mesenchymal stem cells (MSCs) have been shown to secrete exosomes that are cardioprotective. Here, we demonstrated that MSC exosome, a secreted membrane vesicle, is immunologically active. MSC exosomes induced polymyxin-resistant, MYD88-dependent secreted embryonic alkaline phosphatase (SEAP) expres...