Intermittent Fasting Attenuates Obesity-Induced Triple-Negative Breast Cancer Progression by Disrupting Cell Cycle, Epithelial-Mesenchymal Transition, Immune Contexture, and Proinflammatory Signature

• Published in: Nutrients Vol. 16; no. 13; p. 2101
• Main Authors: Son, Deok-Soo, Done, Kaitlyn A, Son, Jubin, Izban, Michael G, Virgous, Carlos, Lee, Eun-Sook, Adunyah, Samuel E
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.07.2024
• Subjects: Animals; Breast cancer; Cell Cycle; Cell growth; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chemotherapy; Cold; Complications and side effects; Disease Progression; Epithelial-Mesenchymal Transition; Fasting; Female; Flow cytometry; Forecasts and trends; Health aspects; Health disparities; Humans; Inflammation; Intermittent Fasting; Mice; Mice, Obese; Minority & ethnic groups; Obesity; Obesity - complications; Penicillin; Phenols; proinflammatory signature; Reducing diets; Triple Negative Breast Neoplasms; triple-negative breast cancer; Tumor Microenvironment; Womens health; United States; United States > US; epithelial–mesenchymal transition; triple-negative breast cancer; intermittent fasting; obesity; proinflammatory signature

Obesity is associated with one-fifth of cancer deaths, and breast cancer is one of the obesity-related cancers. Triple-negative breast cancer (TNBC) lacks estrogen and progesterone receptors and human epidermal growth factor receptor 2, leading to the absence of these therapeutic targets, followed b...