Phenotypic profiling of pancreatic ductal adenocarcinoma plasma-derived small extracellular vesicles for cancer diagnosis and cancer stage prediction: a proof-of-concept study

• Published in: Analytical methods Vol. 14; no. 23; pp. 2255 - 2265
• Main Authors: Zhang, Wei, Wang, Ling, Li, Dan, Campbell, Douglas H, Walsh, Bradley J, Packer, Nicolle H, Dong, Qing, Wang, Erkang, Wang, Yuling
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 16.06.2022
• Subjects: Adenocarcinoma; Assaying; Biomarkers; Biomarkers, Tumor; Body fluids; Cancer; Carcinoma, Pancreatic Ductal - diagnosis; Carcinoma, Pancreatic Ductal - genetics; Carcinoma, Pancreatic Ductal - pathology; Computed tomography; Diagnosis; Extracellular vesicles; Extracellular Vesicles - genetics; Extracellular Vesicles - pathology; Heparan sulfate proteoglycans; Humans; Imaging techniques; Magnetic resonance imaging; Medical diagnosis; Medical imaging; Medical research; Membrane proteins; Membrane Proteins - genetics; Membranes; Organs; Pancreas; Pancreatic Neoplasms; Pancreatic Neoplasms - diagnosis; Pancreatic Neoplasms - genetics; Pancreatic Neoplasms - pathology; Patients; Phenotype; Phenotypes; Plasma; Proteins; Raman spectra; Vesicles

Circulating pancreatic ductal adenocarcinoma (PDAC) derived small extracellular vesicles (sEVs) are nano-sized membranous vesicles secreted from PDAC cells and released into surrounding body fluids, such as blood. The use of plasma-derived sEVs for cancer diagnosis is particularly appealing in biome...