Human Elongation Factor 4 Regulates Cancer Bioenergetics by Acting as a Mitochondrial Translation Switch

• Published in: Cancer research (Chicago, Ill.) Vol. 78; no. 11; pp. 2813 - 2824
• Main Authors: Zhu, Ping, Liu, Yongzhang, Zhang, Fenglin, Bai, Xiufeng, Chen, Zilei, Shangguan, Fugen, Zhang, Bo, Zhang, Lingyun, Chen, Qianqian, Xie, Deyao, Lan, Linhua, Xue, Xiangdong, Liang, Xing-Jie, Lu, Bin, Wei, Taotao, Qin, Yan
• Format: Journal Article
• Language: English
• Published: United States American Association for Cancer Research, Inc 01.06.2018
• Subjects: Apoptosis; Bioenergetics; Cancer; Electron transport; Etiology; Localization; Mitochondria; Mitochondrial DNA; Quality control; Respiration; Translation; Translation elongation; Tumorigenesis

Mitochondria regulate cellular bioenergetics and redox states and influence multiple signaling pathways required for tumorigenesis. In this study, we determined that the mitochondrial translation elongation factor 4 (EF4) is a critical component of tumor progression. EF4 was ubiquitous in human tiss...