Efficacy and security of ivermectin given orally to rats naturally infected with Syphacia spp., Giardia spp. and Hymenolepis nana
The results of this study show that the oral administration of ivermectin (48 mg/L) repeatedly for 72 h used in accordance with the present protocol is a safe and highly effective treatment for Giardia spp. and Hymenolepis nana in laboratory rat colonies. The drug can be easily and safely administer...
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| Published in | Laboratory animals (London) Vol. 49; no. 3; pp. 196 - 200 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
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London, England
SAGE Publications
01.07.2015
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| Abstract | The results of this study show that the oral administration of ivermectin (48 mg/L) repeatedly for 72 h used in accordance with the present protocol is a safe and highly effective treatment for Giardia spp. and Hymenolepis nana in laboratory rat colonies. The drug can be easily and safely administered using drinking water. This simple regimen should control pinworm infection (Syphacia muris), a problem that can be endemic in laboratory colonies. Experiments using healthy animals are likely to generate more consistent results, thereby requiring a reduced number of animals per group. |
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| AbstractList | The results of this study show that the oral administration of ivermectin (48 mg/L) repeatedly for 72 h used in accordance with the present protocol is a safe and highly effective treatment for Giardia spp. and Hymenolepis nana in laboratory rat colonies. The drug can be easily and safely administered using drinking water. This simple regimen should control pinworm infection (Syphacia muris), a problem that can be endemic in laboratory colonies. Experiments using healthy animals are likely to generate more consistent results, thereby requiring a reduced number of animals per group. |
| Author | Tonussi, CR Gazarini, L Stern, CAJ Foletto, VRS Vanz, F |
| Author_xml | – sequence: 1 givenname: VRS surname: Foletto fullname: Foletto, VRS email: vanessafoletto@uol.com.br organization: Department of Pharmacology, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil – sequence: 2 givenname: F surname: Vanz fullname: Vanz, F organization: Department of Pharmacology, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil – sequence: 3 givenname: L surname: Gazarini fullname: Gazarini, L organization: Department of Pharmacology, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil – sequence: 4 givenname: CAJ surname: Stern fullname: Stern, CAJ organization: Department of Pharmacology, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil – sequence: 5 givenname: CR surname: Tonussi fullname: Tonussi, CR organization: Department of Pharmacology, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25480657$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_parint_2020_102127 crossref_primary_10_1007_s00436_017_5631_7 crossref_primary_10_14814_phy2_15510 crossref_primary_10_1016_j_actatropica_2019_03_024 crossref_primary_10_1016_j_bbamcr_2019_118566 crossref_primary_10_3390_vetsci10020169 crossref_primary_10_1038_s41598_020_74299_z crossref_primary_10_1016_j_cvex_2021_04_002 |
| Cites_doi | 10.1128/CMR.11.2.231 10.1017/S0031182005008218 10.1007/BF00431848 10.1007/BF01308343 10.1007/BF03001163 10.1002/9780470344552.ch11 10.1096/fj.07-9574LSF 10.1258/002367794780745263 10.1016/S0016-5085(76)80097-2 10.1645/GE-3356RN 10.1258/002367798780559202 10.1155/2011/942616 10.1258/002367781780958982 10.1016/j.neuroscience.2005.12.064 10.5694/j.1326-5377.1921.tb60654.x 10.1016/B978-0-12-263620-2.50029-X 10.1016/0165-6147(91)90567-C 10.1258/002367776780948862 10.1292/jvms.10-0424 10.1038/npp.2012.63 10.1016/0163-1047(90)91282-G |
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| Keywords | laboratory animals Syphacia Giardia faecal examination Hymenolepis ivermectin |
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| Snippet | The results of this study show that the oral administration of ivermectin (48 mg/L) repeatedly for 72 h used in accordance with the present protocol is a safe... The results of this study show that the oral administration of ivermectin (48 mg/L) repeatedly for 72 h used in accordance with the present protocol is a safe... |
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| SubjectTerms | Administration, Oral Animals Antiparasitic Agents - pharmacology Antiparasitic Agents - therapeutic use Female Gastrointestinal Tract - parasitology Giardia - drug effects Giardiasis - drug therapy Giardiasis - parasitology Giardiasis - veterinary Hymenolepiasis - drug therapy Hymenolepiasis - parasitology Hymenolepiasis - veterinary Hymenolepis nana - drug effects Ivermectin - pharmacology Ivermectin - therapeutic use Male Oxyuriasis - drug therapy Oxyuriasis - parasitology Oxyuriasis - veterinary Oxyuroidea - drug effects Parasite Egg Count - veterinary Rats Rats, Wistar Rodent Diseases - drug therapy Rodent Diseases - parasitology Rodentia |
| Title | Efficacy and security of ivermectin given orally to rats naturally infected with Syphacia spp., Giardia spp. and Hymenolepis nana |
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