Biomimetic peptide nanoparticles participate in natural coagulation for hemostasis and wound healing
Uncontrolled hemorrhage is a major problem both in surgical intervention and after trauma. Herein, we design an in situ constructable peptide network, mimicking and participating in the native coagulation process for enhanced hemostasis and wound healing. The network consists of two peptides includi...
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Published in | Biomaterials science Vol. 1; no. 1; pp. 2628 - 2637 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Royal Society of Chemistry
17.05.2022
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Subjects | |
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Abstract | Uncontrolled hemorrhage is a major problem both in surgical intervention and after trauma. Herein, we design an
in situ
constructable peptide network, mimicking and participating in the native coagulation process for enhanced hemostasis and wound healing. The network consists of two peptides including C
6
KL, mimicking platelets and C
6
KG, mimicking fibrin. The C
6
KL nanoparticles could bind to the collagen at the wound site and transform into C
6
KL nanofibers. The C
6
KG nanoparticles could bind to GPIIb/IIIa receptors on the surface of activated platelets and transform into C
6
KG nanofibers. The
in situ
formed peptide network could interwind platelets, fibrin and red blood cells, causing embolism at the wound site. In a lethal femoral artery, vein, and nerve cut model of rats, the amount of bleeding was reduced to 32.8% by C
6
KL and C
6
KG with chitosan/alginate. The biomimetic peptides show great clinical potential as trauma hemostatic agents.
C
6
KL NPs and C
6
KG NPs enhanced coagulation by
in situ
mimicking and participating in the natural coagulation process. |
---|---|
AbstractList | Uncontrolled hemorrhage is a major problem both in surgical intervention and after trauma. Herein, we design an
in situ
constructable peptide network, mimicking and participating in the native coagulation process for enhanced hemostasis and wound healing. The network consists of two peptides including C
6
KL, mimicking platelets and C
6
KG, mimicking fibrin. The C
6
KL nanoparticles could bind to the collagen at the wound site and transform into C
6
KL nanofibers. The C
6
KG nanoparticles could bind to GPIIb/IIIa receptors on the surface of activated platelets and transform into C
6
KG nanofibers. The
in situ
formed peptide network could interwind platelets, fibrin and red blood cells, causing embolism at the wound site. In a lethal femoral artery, vein, and nerve cut model of rats, the amount of bleeding was reduced to 32.8% by C
6
KL and C
6
KG with chitosan/alginate. The biomimetic peptides show great clinical potential as trauma hemostatic agents.
C
6
KL NPs and C
6
KG NPs enhanced coagulation by
in situ
mimicking and participating in the natural coagulation process. Uncontrolled hemorrhage is a major problem both in surgical intervention and after trauma. Herein, we design an in situ constructable peptide network, mimicking and participating in the native coagulation process for enhanced hemostasis and wound healing. The network consists of two peptides including C6KL, mimicking platelets and C6KG, mimicking fibrin. The C6KL nanoparticles could bind to the collagen at the wound site and transform into C6KL nanofibers. The C6KG nanoparticles could bind to GPIIb/IIIa receptors on the surface of activated platelets and transform into C6KG nanofibers. The in situ formed peptide network could interwind platelets, fibrin and red blood cells, causing embolism at the wound site. In a lethal femoral artery, vein, and nerve cut model of rats, the amount of bleeding was reduced to 32.8% by C6KL and C6KG with chitosan/alginate. The biomimetic peptides show great clinical potential as trauma hemostatic agents. Uncontrolled hemorrhage is a major problem both in surgical intervention and after trauma. Herein, we design an in situ constructable peptide network, mimicking and participating in the native coagulation process for enhanced hemostasis and wound healing. The network consists of two peptides including C 6 KL, mimicking platelets and C 6 KG, mimicking fibrin. The C 6 KL nanoparticles could bind to the collagen at the wound site and transform into C 6 KL nanofibers. The C 6 KG nanoparticles could bind to GPIIb/IIIa receptors on the surface of activated platelets and transform into C 6 KG nanofibers. The in situ formed peptide network could interwind platelets, fibrin and red blood cells, causing embolism at the wound site. In a lethal femoral artery, vein, and nerve cut model of rats, the amount of bleeding was reduced to 32.8% by C 6 KL and C 6 KG with chitosan/alginate. The biomimetic peptides show great clinical potential as trauma hemostatic agents. Uncontrolled hemorrhage is a major problem both in surgical intervention and after trauma. Herein, we design an constructable peptide network, mimicking and participating in the native coagulation process for enhanced hemostasis and wound healing. The network consists of two peptides including C KL, mimicking platelets and C KG, mimicking fibrin. The C KL nanoparticles could bind to the collagen at the wound site and transform into C KL nanofibers. The C KG nanoparticles could bind to GPIIb/IIIa receptors on the surface of activated platelets and transform into C KG nanofibers. The formed peptide network could interwind platelets, fibrin and red blood cells, causing embolism at the wound site. In a lethal femoral artery, vein, and nerve cut model of rats, the amount of bleeding was reduced to 32.8% by C KL and C KG with chitosan/alginate. The biomimetic peptides show great clinical potential as trauma hemostatic agents. |
Author | Zhan, Li-Ning Ding, Meng-Ru Xu, Huan-Ge Zhang, Kuo Qi, Gao-Feng Wang, Lei Cui, Xu Li, Litao Liang, Qi-Lin |
AuthorAffiliation | CAS Center for Excellence in Nanoscience School of Materials Science and Engineering The 4th Medical Center of Chinese PLA General Hospital CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety College of Medicine Southwest Jiaotong University National Center for Nanoscience and Technology (NCNST) Department of Orthopaedics |
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Author_xml | – sequence: 1 givenname: Huan-Ge surname: Xu fullname: Xu, Huan-Ge – sequence: 2 givenname: Qi-Lin surname: Liang fullname: Liang, Qi-Lin – sequence: 3 givenname: Litao surname: Li fullname: Li, Litao – sequence: 4 givenname: Gao-Feng surname: Qi fullname: Qi, Gao-Feng – sequence: 5 givenname: Lei surname: Wang fullname: Wang, Lei – sequence: 6 givenname: Li-Ning surname: Zhan fullname: Zhan, Li-Ning – sequence: 7 givenname: Meng-Ru surname: Ding fullname: Ding, Meng-Ru – sequence: 8 givenname: Kuo surname: Zhang fullname: Zhang, Kuo – sequence: 9 givenname: Xu surname: Cui fullname: Cui, Xu |
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Snippet | Uncontrolled hemorrhage is a major problem both in surgical intervention and after trauma. Herein, we design an
in situ
constructable peptide network,... Uncontrolled hemorrhage is a major problem both in surgical intervention and after trauma. Herein, we design an constructable peptide network, mimicking and... Uncontrolled hemorrhage is a major problem both in surgical intervention and after trauma. Herein, we design an in situ constructable peptide network,... |
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SubjectTerms | Alginates Biomimetics Blood platelets Chitosan Coagulation Erythrocytes Fibrin Hemorrhage Hemostatics Nanofibers Nanoparticles Peptides Platelets Wound healing |
Title | Biomimetic peptide nanoparticles participate in natural coagulation for hemostasis and wound healing |
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