Temporal Profiles of P-Tau, T-Tau, and P-Tau:Tau Ratios in Cerebrospinal Fluid and Blood from Moderate-Severe Traumatic Brain Injury Patients and Relationship to 6-12 Month Global Outcomes

• Published in: Journal of neurotrauma Vol. 41; no. 3-4; p. 369
• Main Authors: Rubenstein, Richard, McQuillan, Leah, Wang, Kevin K W, Robertson, Claudia, Chang, Binggong, Yang, Zhihui, Xu, Haiyan, Williamson, John, Wagner, Amy K
• Format: Journal Article
• Language: English
• Published: United States 01.02.2024
• Subjects: traumatic brain injury; tau; biomarkers; global outcome; phosphorylated tau

Traumatic brain injury (TBI) can initiate progressive injury responses, which are linked to increased risk of neurodegenerative diseases known as "tauopathies." Increased post-TBI tau hyperphosphorylation has been reported in brain tissue and biofluids. Acute-to-chronic TBI total (T)-tau a...