Tyrosine phosphatase Shp2 accelerated the progression of dilated cardiomyopathy via upregulating NF-κB/Src/FAK signaling induced ROS and mitophagy

• Published in: Scientific reports Vol. 15; no. 1; pp. 29522 - 13
• Main Authors: Hao, Jingxia, Wang, Hua, Li, Bo, Chen, Jingshi, Wang, Wenlu, Wang, Yingxue, Zhang, Yingqian
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 12.08.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 631/337; 631/80; Animals; Apoptosis; Autophagy; BMMs; Bone marrow; Cardiomyocytes; Cardiomyopathy; Cardiomyopathy, Dilated - genetics; Cardiomyopathy, Dilated - metabolism; Cardiomyopathy, Dilated - pathology; Dilated cardiomyopathy; Disease Models, Animal; Disease Progression; Ethanol; Fibrosis; Focal adhesion kinase; Focal Adhesion Kinase 1 - metabolism; Heart; Humanities and Social Sciences; Immunofluorescence; Leukocyte migration; Macrophages; Macrophages - metabolism; Male; Mice; Mice, Knockout; Mitophagy; multidisciplinary; Myocardium - metabolism; Myocardium - pathology; Myocytes, Cardiac - metabolism; NF-kappa B - metabolism; NF-κB protein; Oxidative stress; Phosphatase; Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics; Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism; Protein-tyrosine-phosphatase; Reactive oxygen species; Reactive Oxygen Species - metabolism; Science; Science (multidisciplinary); SHP-2; Signal Transduction; Src protein; src-Family Kinases - metabolism; Transmission electron microscopy; Ultrasonic imaging; Up-Regulation; Oxidative stress; SHP-2; Dilated cardiomyopathy; Mitophagy; BMMs

The purpose of this study was to investigate whether tyrosine phosphatase Shp2 can promote the progression of dilated cardiomyopathy by upregulating intracellular oxidative stress and subsequently promoting mitophagy. Macrophage-specific Shp2 knockout mice were cultured and a dilated cardiomyopathy...