Tyrosine phosphatase Shp2 accelerated the progression of dilated cardiomyopathy via upregulating NF-κB/Src/FAK signaling induced ROS and mitophagy - Hao, Jingxia; Wang, Hua; Li, Bo; Chen, Jingshi; Wang, Wenlu; Wang, Yingxue; Zhang, Yingqian (Scientific reports, 2025)
Keywords: 631/337; 631/80; Animals; Apoptosis; Autophagy; BMMs; Bone marrow; Cardiomyocytes; Cardiomyopathy; Cardiomyopathy, Dilated - genetics; Cardiomyopathy, Dilated - metabolism; Cardiomyopathy, Dilated - pathology; Dilated cardiomyopathy; Disease Models, Animal; Disease Progression; Ethanol; Fibrosis; Focal adhesion kinase; Focal Adhesion Kinase 1 - metabolism; Heart; Humanities and Social Sciences; Immunofluorescence; Leukocyte migration; Macrophages; Macrophages - metabolism; Male; Mice; Mice, Knockout; Mitophagy; multidisciplinary; Myocardium - metabolism; Myocardium - pathology; Myocytes, Cardiac - metabolism; NF-kappa B - metabolism; NF-κB protein; Oxidative stress; Phosphatase; Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics; Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism; Protein-tyrosine-phosphatase; Reactive oxygen species; Reactive Oxygen Species - metabolism; Science; Science (multidisciplinary); SHP-2; Signal Transduction; Src protein; src-Family Kinases - metabolism; Transmission electron microscopy; Ultrasonic imaging; Up-Regulation; Oxidative stress; SHP-2; Dilated cardiomyopathy; Mitophagy; BMMs