High erythropoietin levels are associated with low neurofilament light levels in simulated high altitude: a further hint for neuroprotection by erythropoietin

• Published in: Frontiers in neurology Vol. 16; p. 1608763
• Main Authors: Berek, Klaus, Berek, Anna, Bauer, Angelika, Rudzki, Dagmar, Di Pauli, Franziska, Bsteh, Gabriel, Ponleitner, Markus, Treml, Benedikt, Kleinsasser, Axel, Berger, Thomas, Wille, Maria, Burtscher, Martin, Reindl, Markus, Deisenhammer, Florian, Hegen, Harald
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 2025
• Subjects: acute mountain sickness; axonal damage; erythropoietin; high altitude; neurofilament light; Neurology; axonal damage; high altitude; acute mountain sickness; neurofilament light; erythropoietin

Erythropoietin (EPO) plays a crucial role in the early adaption to high altitude and is possibly involved in neuroprotection. Neurofilament light chain (NfL) is an established marker of neuroaxonal damage. To investigate whether EPO dynamics in simulated high altitude are linked to neuroaxonal damag...