Long-Term Functional and Cytoarchitectonic Effects of the Systemic Administration of the Histamine H1 Receptor Antagonist/Inverse Agonist Chlorpheniramine During Gestation in the Rat Offspring Primary Motor Cortex

• Published in: Frontiers in neuroscience Vol. 15; p. 740282
• Main Authors: Valle-Bautista, Rocío, Márquez-Valadez, Berenice, Herrera-López, Gabriel, Griego, Ernesto, Galván, Emilio J., Díaz, Néstor-Fabián, Arias-Montaño, José-Antonio, Molina-Hernández, Anayansi
• Format: Journal Article
• Language: English
• Published: Lausanne Frontiers Research Foundation 24.01.2022; Frontiers Media S.A
• Subjects: Brain architecture; Cell activation; Cell differentiation; Cerebral cortex; cerebral cortex development; chlorpheniramine; Cognition; Cortex (motor); cortical function; Cyclin-dependent kinase inhibitor p21; cytoarchitecture; Dendritic branching; Depolarization; Embryos; Excitability; Foxp2 protein; GTP-binding protein; Hindbrain; Histamine; Histamine H1 receptors; Histidine; Histidine decarboxylase; hitamine H1 receptor; Immunofluorescence; Juveniles; Laboratory animals; Motor activity; Neonates; Neostriatum; Neural stem cells; Neurogenesis; Neurons; Neuroscience; Pain perception; pregnancy; Values; United States > US

The transient histaminergic system is among the first neurotransmitter systems to appear during brain development in the rat mesencephalon/rhombencephalon. Histamine increases FOXP2-positive deep-layer neuron differentiation of cortical neural stem cells through H 1 receptor activation in vitro . Th...