Extrachromosomal telomere DNA derived from excessive strand displacements

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 121; no. 19; p. e2318438121
• Main Authors: Lee, Junyeop, Lee, Jina, Sohn, Eric J., Taglialatela, Angelo, O’Sullivan, Roderick J., Ciccia, Alberto, Min, Jaewon
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 07.05.2024
• Subjects: Biological Sciences; Blotting, Southern; Cancer; Cytoplasm; Deoxyribonucleic acid; DNA; DNA - genetics; DNA - metabolism; DNA biosynthesis; DNA helicase; DNA polymerase; DNA Polymerase III - genetics; DNA Polymerase III - metabolism; DNA Replication; DNA, Circular - genetics; DNA, Circular - metabolism; DNA, Single-Stranded - genetics; DNA, Single-Stranded - metabolism; DNA-directed DNA polymerase; Humans; Nucleotides; Primase; Single-stranded DNA; Synthesis; Telomere - genetics; Telomere - metabolism; Telomere Homeostasis; Telomeres; POLD3; C-circle; BLM; CST; break-induced replication

Alternative lengthening of telomeres (ALT) is a telomere maintenance mechanism mediated by break-induced replication, evident in approximately 15% of human cancers. A characteristic feature of ALT cancers is the presence of C-circles, circular single-stranded telomeric DNAs composed of C-rich sequen...