Early In-Bed Cycle Ergometry With Critically Ill, Mechanically Ventilated Patients: Statistical Analysis Plan for CYCLE (Critical Care Cycling to Improve Lower Extremity Strength), an International, Multicenter, Randomized Clinical Trial

• Published in: JMIR research protocols Vol. 13; p. e54451
• Main Authors: Heels-Ansdell, Diane, Kelly, Laurel, O'Grady, Heather K, Farley, Christopher, Reid, Julie C, Berney, Sue, Pastva, Amy M, Burns, Karen EA, D'Aragon, Frédérick, Herridge, Margaret S, Seely, Andrew, Rudkowski, Jill, Rochwerg, Bram, Fox-Robichaud, Alison, Ball, Ian, Lamontagne, Francois, Duan, Erick H, Tsang, Jennifer, Archambault, Patrick M, Verceles, Avelino C, Muscedere, John, Mehta, Sangeeta, English, Shane W, Karachi, Tim, Serri, Karim, Reeve, Brenda, Thabane, Lehana, Cook, Deborah, Kho, Michelle E
• Format: Journal Article
• Language: English
• Published: Canada JMIR Publications 28.10.2024
• Subjects: Adult; Age; Clinical trials; Consent; Critical care; Critical Care - methods; Critical Illness; Ergometry - methods; Ethics; Female; Frailty; Guillain-Barre syndrome; Humans; Intensive care; Intensive Care Units; Intervention; Lower Extremity; Male; Middle Aged; Muscle Strength; Patients; Physical therapy; Proposal; Quantitative psychology; Randomized Controlled Trials as Topic; Regression analysis; Rehabilitation; Respiration, Artificial; Statistical analysis; Ventilators; Canada; United States > US; cycle ergometry; rehabilitation; exercise therapy; mechanical ventilation; critical illness; recovery of function

Survivors of critical illness are at risk of developing physical dysfunction following intensive care unit (ICU) discharge. ICU-based rehabilitation interventions, such as early in-bed cycle ergometry, may improve patients' short-term physical function. Before unblinding and trial database lock...