Serum profiling of the antibody response to HPV in women with or without abnormal cervical cytology undergoing cervical cancer screening

• Published in: Frontiers in immunology Vol. 16; p. 1612761
• Main Authors: Ewaisha, Radwa, Ruffin, Mack T., Williams, Stacy, Chung, Yunro, DeGraffinreid, Cecilia R., Paskett, Electra D., Reiter, Paul L., Qiu, Ji, Brenner, Dean E., Anderson, Karen S.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 2025
• Subjects: Adult; Aged; antibodies; Antibodies, Viral - blood; Antibodies, Viral - immunology; cervical cancer; cervical intraepithelial neoplasia; Early Detection of Cancer; Female; HPV; Humans; Immunology; Middle Aged; NAPPA; Papillomaviridae - immunology; Papillomavirus Infections - blood; Papillomavirus Infections - diagnosis; Papillomavirus Infections - immunology; Papillomavirus Infections - virology; protein microarrays; Uterine Cervical Neoplasms - blood; Uterine Cervical Neoplasms - diagnosis; Uterine Cervical Neoplasms - immunology; Uterine Cervical Neoplasms - virology; early detection antibodies; NAPPA; serology; antibodies; protein microarrays; cervical cancer; cervical intraepithelial neoplasia; HPV

Understanding the humoral immune response to HPV is important for understanding the natural history of infection and developing biomarkers for early detection of cervical cancer. This has been technically limited by HPV type diversity and challenges of high-throughput protein expression and display....