A novel mutation from gene splicing of a voltage-gated sodium channel in a marine copepod and its potential effect on channel function

• Published in: Journal of experimental marine biology and ecology Vol. 469; pp. 131 - 142
• Main Authors: Chen, Lihua, Zhang, Huan, Finiguerra, Michael, Bobkov, Yuriy, Bouchard, Christelle, Avery, David E., Anderson, Peter A.V., Lin, Senjie, Dam, Hans G.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.08.2015
• Subjects: Acartia hudsonica; Alexandrium fundyense; Alternative splicing; Copepod; Cyanobacteria; Electrophysiology; Marine; Saxitoxin; Sodium channel; Electrophysiology; Alternative splicing; Copepod; Saxitoxin; Sodium channel

The saxitoxins (STX), a group of potent neurotoxins produced by some marine algae (dinoflagellates and cyanobacteria), block voltage-gated sodium channels, inhibiting nerve-signal transmission in consumers of STX-bearing prey. Populations of grazers (clams and copepods) persistently exposed to the S...