New induction of leukotriene A4 hydrolase by interleukin-4 and interleukin-13 in human polymorphonuclear leukocytes

• Published in: Blood Vol. 96; no. 2; pp. 601 - 609
• Main Authors: ZAITSU, M, HAMASAKI, Y, ICHIMARU, T, KOHASHI, O, MIYAZAKI, S, MATSUO, M, KUKITA, A, TSUJI, K, MIYAZAKI, M, HAYASAKI, R, MURO, E, YAMAMOTO, S, KOBAYASHI, I
• Format: Journal Article
• Language: English
• Published: Washington, DC The Americain Society of Hematology 15.07.2000
• Subjects: Allergic diseases; Biological and medical sciences; General aspects; Immunopathology; Medical sciences; Human; Immunopathology; Allergy; Pathophysiology; Enzyme; Cytokine; Granulocyte; Inflammation; Interleukin 13; Chemotaxis; Leukotriene; Interleukin 4; Leukotriene B4; hydrolase; Interleukin 10; Ether hydrolases; Hydrolases; Leukotriene-A; Neutrophil

Abstract Interleukin (IL)-4, IL-10, and IL-13, Th2 cell–derived cytokines, play major roles in the pathophysiology of allergic diseases. These cytokines up-regulate or down-regulate the production of arachidonic acid metabolites. In this study, we have investigated the effect of IL-4, IL-10, IL-13,...