p53 protein, interferon-γ, and NF-κB levels are elevated in the parkinsonian brain

• Published in: Neuroscience letters Vol. 414; no. 1; pp. 94 - 97
• Main Authors: Mogi, Makio, Kondo, Tomoyoshi, Mizuno, Yoshikuni, Nagatsu, Toshiharu
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 27.02.2007; Elsevier
• Subjects: Biological and medical sciences; Brain; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Fundamental and applied biological sciences. Psychology; Interferon-γ; Medical sciences; Neurology; NF-κB; p53 protein; Parkinson's disease; Vertebrates: nervous system and sense organs; Brain; NF-κB; TGF; IL; Parkinson's disease; PD; PMSF; Interferon-γ; CNS; TNF; p53 protein; ELISA; Nervous system diseases; p53 Protein; NF-KB; Parkinson disease; Cerebral disorder; Central nervous system disease; Degenerative disease; Transcription factor NFκB; Extrapyramidal syndrome; Gamma interferon

We and other workers found markedly increased levels of proinflammatory cytokines and apoptosis-related proteins in parkinsonian brain. Although the pathogenesis of Parkinson's disease (PD) remains enigmatic, apoptosis might be involved in the degeneration of dopaminergic neurons in PD. To inve...