House Dust Mite-Specific Immunotherapy Alters the Basal Expression of T Regulatory and FcεRI Pathway Genes

• Published in: International archives of allergy and immunology Vol. 159; no. 3; pp. 287 - 296
• Main Authors: Pevec, Branko, Radulovic Pevec, Mira, Stipic Markovic, Asja, Batista, Irena, Rijavec, Matija, Silar, Mira, Kosnik, Mitja, Korosec, Peter
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland Karger 01.01.2012
• Subjects: Adult; Allergens - administration & dosage; Allergens - immunology; Animals; Biological and medical sciences; Case-Control Studies; Complex Mixtures - administration & dosage; Complex Mixtures - immunology; Dermatophagoides pteronyssinus - immunology; Female; Forkhead Transcription Factors - genetics; Forkhead Transcription Factors - immunology; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Gene Expression - drug effects; Gene Expression - immunology; Humans; Hypersensitivity - genetics; Hypersensitivity - immunology; Hypersensitivity - therapy; Immunoglobulin E - genetics; Immunoglobulin E - immunology; Immunopathology; Immunotherapy; Inositol Polyphosphate 5-Phosphatases; Intracellular Signaling Peptides and Proteins - genetics; Intracellular Signaling Peptides and Proteins - immunology; Male; Medical sciences; Nasal Provocation Tests; Original Paper; Phosphoric Monoester Hydrolases - genetics; Phosphoric Monoester Hydrolases - immunology; Protein-Tyrosine Kinases - genetics; Protein-Tyrosine Kinases - immunology; Receptors, IgE - genetics; Receptors, IgE - immunology; RNA, Messenger - biosynthesis; RNA, Messenger - immunology; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Signal Transduction - drug effects; Signal Transduction - genetics; Signal Transduction - immunology; Skin Tests; Syk Kinase; T-Box Domain Proteins - genetics; T-Box Domain Proteins - immunology; T-Lymphocytes, Regulatory - drug effects; T-Lymphocytes, Regulatory - immunology; Gene expression; Specific immunotherapy; House dust mite; Immunopathology; House dust; FcεRI receptor; Immunoglobulin receptor; Mite; Immunology; Treatment; Gene; Immunotherapy; Genetics

Background: Regulatory T (Treg) cells and IgE-mediated signaling pathways could play important roles in the induction of allergen tolerance during house dust mite-specific subcutaneous immunotherapy (HDM-SCIT). Our aim was to compare the basal expression levels of Treg, T helper 1 (Th1) and Th2 tran...