3D hierarchic interfacial assembly of Au nanocage@Au along with IS-AgMNPs for simultaneous, ultrasensitive, reliable, and quantitative SERS detection of colorectal cancer related miRNAs

• Published in: Biosensors & bioelectronics Vol. 248; p. 115993
• Main Authors: Wu, Jiamin, Li, Shengrong, Ma, Yiling, Zhi, Weixia, Chen, Tingting, Huang, Xueqin, Huang, Chan, Zhou, Xia, Zhang, Pengcheng, Zhang, Yuan, Zheng, Guangchao, Wang, Zhigang, Zhong, Xing, Cai, Huaihong, Wang, Wenxia, Sun, Pinghua, Zhou, Haibo
• Format: Journal Article
• Language: English
• Published: England 15.03.2024
• Subjects: biomarkers; biosensors; blood serum; calibration; colorectal neoplasms; detection limit; early diagnosis; lymph nodes; magnetism; metastasis; microRNA; nanoparticles; prediction; prognosis; quantitative analysis; Hierarchic interfacial assembly; Biosensors; SERS; Internal standard; MiRNA

Simultaneous, reliable, and ultra-sensitive analysis of promising miRNA biomarkers of colorectal cancer (CRC) in serum is critical for early diagnosis and prognosis of CRC. In this work, we proposed a novel 3D hierarchic assembly clusters-based SERS strategy with dual enrichment and enhancement desi...