Synthesis of ecdysteroid inhibitors of ecdysone biosynthesis. Inhibition of the C-25 hydroxylation

Condensation of acetylenic nucleophiles on the i-ether 1 leads to new inhibitors of the ecdysone biosynthesis, possessing a hydroxy group at C-22. The synthesis of four inhibitors, containing a hydroxy group at C-22 and an acetylenic function at C-24 or C-25 is described.

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Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 3; no. 10; pp. 1951 - 1952
Main Authors Mauvais, Antony, Hetru, Charles, Luu, Bang
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.10.1993
Elsevier
Subjects
Acetylenic inhibitor
Biological and medical sciences
C-25 Hydroxylase
Ecdysone
General and cellular metabolism. Vitamins
Medical sciences
Pharmacology. Drug treatments
C-25 Hydroxylase
Acetylenic inhibitor
Ecdysone
Acetylenic compound
Enzyme
Ecdysteroide
Hydroxylase
Enzyme inhibitor
Biosynthesis
Chemical synthesis
Nucleophile
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Summary:Condensation of acetylenic nucleophiles on the i-ether 1 leads to new inhibitors of the ecdysone biosynthesis, possessing a hydroxy group at C-22. The synthesis of four inhibitors, containing a hydroxy group at C-22 and an acetylenic function at C-24 or C-25 is described.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(01)80993-8