Soy isoflavone supplementation in healthy men prevents NF-κB activation by TNF-α in blood lymphocytes

• Published in: Free radical biology & medicine Vol. 30; no. 11; pp. 1293 - 1302
• Main Authors: Davis, Joanne N, Kucuk, Omer, Djuric, Zora, Sarkar, Fazlul H
• Format: Journal Article
• Language: English
• Published: United States 01.06.2001
• Subjects: 5-hydroxymethyl-2'-deoxyuridine; Adult; Antioxidants - administration & dosage; daidzein; Dietary Supplements; Genistein - administration & dosage; Glycine max; Humans; Isoflavones - administration & dosage; Lymphocytes - drug effects; Lymphocytes - metabolism; Male; NF-kappa B - metabolism; Tumor Necrosis Factor-alpha - pharmacology

Dietary intake of soy has been associated with a decreased risk of cancer. Soy isoflavones have been postulated to be the protective compounds in soybeans; however, the precise mechanism by which soy isoflavones prevent human cancer is not known. The major soy isoflavones, genistein and daidzein, ar...