Integrated transcriptomic and metabolomic analysis of the global response of Staphylococcus aureus to ohmic heating

Ohmic heating (OH), an alternative thermal processing method, has been widely used for the pasteurization of foods. To further understand the inactivation mechanism on microorganisms and the formation of sublethally injured cells subject to OH treatment, transcriptomic and metabolomic changes of Sta...

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Published inInnovative food science & emerging technologies Vol. 74; p. 102870
Main Authors Shao, Lele, Liu, Yi, Zhao, Yijie, Zou, Bo, Li, Xingmin, Dai, Ruitong
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.12.2021
Subjects
Amino acids metabolism
cell membranes
energy
Energy metabolism
heat
metabolic diseases
Metabolomic
metabolomics
Non-thermal effect
ohmic heating
Osmotic imbalance
pasteurization
secondary metabolites
Staphylococcus aureus
Transcriptomic
transcriptomics
virulence
Amino acids metabolism
Metabolomic
Energy metabolism
Non-thermal effect
Transcriptomic
Osmotic imbalance
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Abstract Ohmic heating (OH), an alternative thermal processing method, has been widely used for the pasteurization of foods. To further understand the inactivation mechanism on microorganisms and the formation of sublethally injured cells subject to OH treatment, transcriptomic and metabolomic changes of Staphylococcus aureus treated with OH and water bath heating (WB) were characterized. There were 349 and 180 differential genes and metabolites after OH treatment, respectively. Amino acids and their secondary metabolites accounted for the largest proportion of differential metabolites for the two treatments, while the majority of differential metabolites between the two heating methods were lipids. The results indicated that OH led to osmotic imbalance, cell membrane damage and energy metabolism disorder of S. aureus. Meanwhile, replication, transcription and translation were inhibited, virulence factors also decreased after OH treatment. Sublethally injured cells induced by OH required increased energy to maintain osmotic, repair damaged membrane and express selective genes for survival. •Ohmic heating treatment showed 349 and 180 differential genes and metabolites.•Osmotic imbalance and amino acids limitation were observed in ohmic-heated S. aureus.•Energy metabolism disorder in ohmic-heated S. aureus were observed.•Growth and reproduction of S. aureus were inhibited after ohmic heating.•Injured cells required more energy and selective genes expression for survival.
AbstractList Ohmic heating (OH), an alternative thermal processing method, has been widely used for the pasteurization of foods. To further understand the inactivation mechanism on microorganisms and the formation of sublethally injured cells subject to OH treatment, transcriptomic and metabolomic changes of Staphylococcus aureus treated with OH and water bath heating (WB) were characterized. There were 349 and 180 differential genes and metabolites after OH treatment, respectively. Amino acids and their secondary metabolites accounted for the largest proportion of differential metabolites for the two treatments, while the majority of differential metabolites between the two heating methods were lipids. The results indicated that OH led to osmotic imbalance, cell membrane damage and energy metabolism disorder of S. aureus. Meanwhile, replication, transcription and translation were inhibited, virulence factors also decreased after OH treatment. Sublethally injured cells induced by OH required increased energy to maintain osmotic, repair damaged membrane and express selective genes for survival.
Ohmic heating (OH), an alternative thermal processing method, has been widely used for the pasteurization of foods. To further understand the inactivation mechanism on microorganisms and the formation of sublethally injured cells subject to OH treatment, transcriptomic and metabolomic changes of Staphylococcus aureus treated with OH and water bath heating (WB) were characterized. There were 349 and 180 differential genes and metabolites after OH treatment, respectively. Amino acids and their secondary metabolites accounted for the largest proportion of differential metabolites for the two treatments, while the majority of differential metabolites between the two heating methods were lipids. The results indicated that OH led to osmotic imbalance, cell membrane damage and energy metabolism disorder of S. aureus. Meanwhile, replication, transcription and translation were inhibited, virulence factors also decreased after OH treatment. Sublethally injured cells induced by OH required increased energy to maintain osmotic, repair damaged membrane and express selective genes for survival. •Ohmic heating treatment showed 349 and 180 differential genes and metabolites.•Osmotic imbalance and amino acids limitation were observed in ohmic-heated S. aureus.•Energy metabolism disorder in ohmic-heated S. aureus were observed.•Growth and reproduction of S. aureus were inhibited after ohmic heating.•Injured cells required more energy and selective genes expression for survival.
ArticleNumber 102870
Author Zou, Bo
Dai, Ruitong
Li, Xingmin
Zhao, Yijie
Shao, Lele
Liu, Yi
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  surname: Liu
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  surname: Zhao
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  email: dairuitong@hotmail.com
  organization: College of Food Science and Nutritional Engineering, China Agricultural University, No. 17 Qinghua East Road, Haidian District, Beijing 100083, PR China
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Keywords Amino acids metabolism
Metabolomic
Energy metabolism
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Transcriptomic
Osmotic imbalance
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Snippet Ohmic heating (OH), an alternative thermal processing method, has been widely used for the pasteurization of foods. To further understand the inactivation...
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SubjectTerms Amino acids metabolism
cell membranes
energy
Energy metabolism
heat
metabolic diseases
Metabolomic
metabolomics
Non-thermal effect
ohmic heating
Osmotic imbalance
pasteurization
secondary metabolites
Staphylococcus aureus
Transcriptomic
transcriptomics
virulence
Title Integrated transcriptomic and metabolomic analysis of the global response of Staphylococcus aureus to ohmic heating
URI https://dx.doi.org/10.1016/j.ifset.2021.102870
https://www.proquest.com/docview/2636500269
Volume 74
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