Study on the antidepressant activity of (2R,6R; 2S,6S)-Hydroxynorketamine (HNK) and its derivatives
•In the case of 10 mg HNK treatment, compared with saline, the immobile time of compound C and D groups in the glass cylinder area was significantly different.•In the locomotor sensitization test, the movement distance of compound C and D groups on day 15 and day 7 mice increased significantly compa...
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| Published in | Clinics (São Paulo, Brazil) Vol. 79; p. 100435 |
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| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English Portuguese |
| Published |
United States
Elsevier España, S.L.U
01.01.2024
Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo Faculdade de Medicina / USP |
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| Abstract | •In the case of 10 mg HNK treatment, compared with saline, the immobile time of compound C and D groups in the glass cylinder area was significantly different.•In the locomotor sensitization test, the movement distance of compound C and D groups on day 15 and day 7 mice increased significantly compared with the first day.•In the conditioned place preference experiment, compound C and compound D induced conditioned place preference in mice compared with the Veh group.
This study mainly explores (2R,6R; 2S,6S)-HNK and its compounds whether there are antidepressant effects.
Four HNK compounds were obtained from 2-(Chlorophenyl) Cyclopentylmethanone. Forced swimming test, locomotor sensitization test, and conditioned location preference test were used to screen the antidepressant activity of the synthesized target compounds.
In the case of 10 mg HNK treatment, compared with saline, the immobile time of mice in the HNK group, I5 group and I6 group at 1 h and 7 days had statistical significance. In the case of 10 mg HNK treatment, compared with saline, the immobile time of compound C and D groups in the glass cylinder area was significantly different. In the locomotor sensitization test, the movement distance of compound C and D groups on day 15 and day 7 mice increased significantly compared with the first day. In the conditioned place preference experiment, compound C and compound D induced conditioned place preference in mice compared with the Veh group.
The results of the forced swimming test, locomotor sensitization test, and conditioned location preference test showed that compounds C and D may have certain anti-depressant activity. However, HNK exerts a rapid and significant antidepressant effect within 1 week, but the duration is short. |
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| AbstractList | •
In the case of 10 mg HNK treatment, compared with saline, the immobile time of compound C and D groups in the glass cylinder area was significantly different.
•
In the locomotor sensitization test, the movement distance of compound C and D groups on day 15 and day 7 mice increased significantly compared with the first day.
•
In the conditioned place preference experiment, compound C and compound D induced conditioned place preference in mice compared with the Veh group. Abstract Objective: This study mainly explores (2R,6R; 2S,6S)-HNK and its compounds whether there are antidepressant effects. Methods: Four HNK compounds were obtained from 2-(Chlorophenyl) Cyclopentylmethanone. Forced swimming test, locomotor sensitization test, and conditioned location preference test were used to screen the antidepressant activity of the synthesized target compounds. Results: In the case of 10 mg HNK treatment, compared with saline, the immobile time of mice in the HNK group, I5 group and I6 group at 1 h and 7 days had statistical significance. In the case of 10 mg HNK treatment, compared with saline, the immobile time of compound C and D groups in the glass cylinder area was significantly different. In the locomotor sensitization test, the movement distance of compound C and D groups on day 15 and day 7 mice increased significantly compared with the first day. In the conditioned place preference experiment, compound C and compound D induced conditioned place preference in mice compared with the Veh group. Conclusion: The results of the forced swimming test, locomotor sensitization test, and conditioned location preference test showed that compounds C and D may have certain anti-depressant activity. However, HNK exerts a rapid and significant antidepressant effect within 1 week, but the duration is short. This study mainly explores (2R,6R; 2S,6S)-HNK and its compounds whether there are antidepressant effects. Four HNK compounds were obtained from 2-(Chlorophenyl) Cyclopentylmethanone. Forced swimming test, locomotor sensitization test, and conditioned location preference test were used to screen the antidepressant activity of the synthesized target compounds. In the case of 10 mg HNK treatment, compared with saline, the immobile time of mice in the HNK group, I5 group and I6 group at 1 h and 7 days had statistical significance. In the case of 10 mg HNK treatment, compared with saline, the immobile time of compound C and D groups in the glass cylinder area was significantly different. In the locomotor sensitization test, the movement distance of compound C and D groups on day 15 and day 7 mice increased significantly compared with the first day. In the conditioned place preference experiment, compound C and compound D induced conditioned place preference in mice compared with the Veh group. The results of the forced swimming test, locomotor sensitization test, and conditioned location preference test showed that compounds C and D may have certain anti-depressant activity. However, HNK exerts a rapid and significant antidepressant effect within 1 week, but the duration is short. •In the case of 10 mg HNK treatment, compared with saline, the immobile time of compound C and D groups in the glass cylinder area was significantly different.•In the locomotor sensitization test, the movement distance of compound C and D groups on day 15 and day 7 mice increased significantly compared with the first day.•In the conditioned place preference experiment, compound C and compound D induced conditioned place preference in mice compared with the Veh group. This study mainly explores (2R,6R; 2S,6S)-HNK and its compounds whether there are antidepressant effects. Four HNK compounds were obtained from 2-(Chlorophenyl) Cyclopentylmethanone. Forced swimming test, locomotor sensitization test, and conditioned location preference test were used to screen the antidepressant activity of the synthesized target compounds. In the case of 10 mg HNK treatment, compared with saline, the immobile time of mice in the HNK group, I5 group and I6 group at 1 h and 7 days had statistical significance. In the case of 10 mg HNK treatment, compared with saline, the immobile time of compound C and D groups in the glass cylinder area was significantly different. In the locomotor sensitization test, the movement distance of compound C and D groups on day 15 and day 7 mice increased significantly compared with the first day. In the conditioned place preference experiment, compound C and compound D induced conditioned place preference in mice compared with the Veh group. The results of the forced swimming test, locomotor sensitization test, and conditioned location preference test showed that compounds C and D may have certain anti-depressant activity. However, HNK exerts a rapid and significant antidepressant effect within 1 week, but the duration is short. This study mainly explores (2R,6R; 2S,6S)-HNK and its compounds whether there are antidepressant effects.OBJECTIVEThis study mainly explores (2R,6R; 2S,6S)-HNK and its compounds whether there are antidepressant effects.Four HNK compounds were obtained from 2-(Chlorophenyl) Cyclopentylmethanone. Forced swimming test, locomotor sensitization test, and conditioned location preference test were used to screen the antidepressant activity of the synthesized target compounds.METHODSFour HNK compounds were obtained from 2-(Chlorophenyl) Cyclopentylmethanone. Forced swimming test, locomotor sensitization test, and conditioned location preference test were used to screen the antidepressant activity of the synthesized target compounds.In the case of 10 mg HNK treatment, compared with saline, the immobile time of mice in the HNK group, I5 group and I6 group at 1 h and 7 days had statistical significance. In the case of 10 mg HNK treatment, compared with saline, the immobile time of compound C and D groups in the glass cylinder area was significantly different. In the locomotor sensitization test, the movement distance of compound C and D groups on day 15 and day 7 mice increased significantly compared with the first day. In the conditioned place preference experiment, compound C and compound D induced conditioned place preference in mice compared with the Veh group.RESULTSIn the case of 10 mg HNK treatment, compared with saline, the immobile time of mice in the HNK group, I5 group and I6 group at 1 h and 7 days had statistical significance. In the case of 10 mg HNK treatment, compared with saline, the immobile time of compound C and D groups in the glass cylinder area was significantly different. In the locomotor sensitization test, the movement distance of compound C and D groups on day 15 and day 7 mice increased significantly compared with the first day. In the conditioned place preference experiment, compound C and compound D induced conditioned place preference in mice compared with the Veh group.The results of the forced swimming test, locomotor sensitization test, and conditioned location preference test showed that compounds C and D may have certain anti-depressant activity. However, HNK exerts a rapid and significant antidepressant effect within 1 week, but the duration is short.CONCLUSIONThe results of the forced swimming test, locomotor sensitization test, and conditioned location preference test showed that compounds C and D may have certain anti-depressant activity. However, HNK exerts a rapid and significant antidepressant effect within 1 week, but the duration is short. |
| ArticleNumber | 100435 |
| Author | Li, Shupeng Mei, Xi Shi, Xin Yang, Xuemei Feng, Jinxing Tan, Zhen Zang, Dongdong Li, Zhenxing Liu, Jianxi Wang, Hao Ma, Yanjun |
| AuthorAffiliation | Peking University Guangdong Engineering Technological Research Center for Nervous anatomy and Related Clinical Applications Shenzhen People’s Hospital Zhuhai Pengkun Biomedicine Technology Co. LTD Shenzhen Ruijian Biotechnology Co., LTD Shenzhen Children’s Hospital Shenzhen University |
| AuthorAffiliation_xml | – name: Shenzhen University – name: Shenzhen Children’s Hospital – name: Guangdong Engineering Technological Research Center for Nervous anatomy and Related Clinical Applications – name: Peking University – name: Shenzhen Ruijian Biotechnology Co., LTD – name: Zhuhai Pengkun Biomedicine Technology Co. LTD – name: Shenzhen People’s Hospital |
| Author_xml | – sequence: 1 givenname: Dongdong orcidid: 0009-0002-9578-9536 surname: Zang fullname: Zang, Dongdong organization: Department of Neonatology, Shenzhen Children's Hospital, Shenzhen City, Guangdong Province, China – sequence: 2 givenname: Xuemei orcidid: 0009-0006-1111-235X surname: Yang fullname: Yang, Xuemei organization: Health Management Center, Shenzhen University General Hospital, Shenzhen University Clinical Medical Academy, Shenzhen University, Shenzhen City, Guangdong Province, China – sequence: 3 givenname: Hao orcidid: 0009-0003-5987-1222 surname: Wang fullname: Wang, Hao organization: Department of Neurosurgery, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen City, Guangdong Province, China – sequence: 4 givenname: Zhenxing orcidid: 0009-0003-2901-7965 surname: Li fullname: Li, Zhenxing organization: Health Management Center, Shenzhen University General Hospital, Shenzhen University Clinical Medical Academy, Shenzhen University, Shenzhen City, Guangdong Province, China – sequence: 5 givenname: Yanjun orcidid: 0009-0001-9091-0555 surname: Ma fullname: Ma, Yanjun organization: Shenzhen Ruijian Biotechnology Co., LTD, Shenzhen City, Guangdong Province, China – sequence: 6 givenname: Jianxi orcidid: 0009-0005-0685-1409 surname: Liu fullname: Liu, Jianxi organization: Shenzhen Ruijian Biotechnology Co., LTD, Shenzhen City, Guangdong Province, China – sequence: 7 givenname: Xi orcidid: 0009-0007-8557-2479 surname: Mei fullname: Mei, Xi organization: Zhuhai Pengkun Biomedicine Technology Co. LTD, Zhuhai City, Guangdong Province, China – sequence: 8 givenname: Shupeng orcidid: 0009-0003-6588-3086 surname: Li fullname: Li, Shupeng organization: State Key Laboratory of Oncogenomics, School of Chemical Biology and Biotechnology, Peking University, Shenzhen City, Guangdong Province, China – sequence: 9 givenname: Jinxing orcidid: 0009-0009-4413-6149 surname: Feng fullname: Feng, Jinxing organization: Department of Neonatology, Shenzhen Children's Hospital, Shenzhen City, Guangdong Province, China – sequence: 10 givenname: Xin orcidid: 0009-0007-3510-2823 surname: Shi fullname: Shi, Xin organization: Department of Neurosurgery, Shenzhen University General Hospital and Shenzhen University Clinical Medical Academy Centre, Shenzhen University, Shenzhen City, Guangdong Province, China – sequence: 11 givenname: Zhen orcidid: 0000-0002-0187-6755 surname: Tan fullname: Tan, Zhen email: tanzhen@szu.edu.cn organization: Department of Neonatology, Shenzhen Children's Hospital, Shenzhen City, Guangdong Province, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38996724$$D View this record in MEDLINE/PubMed |
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| Keywords | Antidepressant Conditioned Place Preference Test Forced Swimming Test Behavioral Sensitization Test Hydroxynorketamine and its Derivatives |
| Language | English Portuguese |
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| Snippet | •In the case of 10 mg HNK treatment, compared with saline, the immobile time of compound C and D groups in the glass cylinder area was significantly... This study mainly explores (2R,6R; 2S,6S)-HNK and its compounds whether there are antidepressant effects. Four HNK compounds were obtained from... This study mainly explores (2R,6R; 2S,6S)-HNK and its compounds whether there are antidepressant effects.OBJECTIVEThis study mainly explores (2R,6R; 2S,6S)-HNK... • In the case of 10 mg HNK treatment, compared with saline, the immobile time of compound C and D groups in the glass cylinder area was significantly... Abstract Objective: This study mainly explores (2R,6R; 2S,6S)-HNK and its compounds whether there are antidepressant effects. Methods: Four HNK compounds were... |
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| SubjectTerms | Antidepressant Behavioral Sensitization Test Conditioned Place Preference Test Forced Swimming Test Hydroxynorketamine and its Derivatives MEDICINE, GENERAL & INTERNAL Original |
| Title | Study on the antidepressant activity of (2R,6R; 2S,6S)-Hydroxynorketamine (HNK) and its derivatives |
| URI | https://dx.doi.org/10.1016/j.clinsp.2024.100435 https://www.ncbi.nlm.nih.gov/pubmed/38996724 https://www.proquest.com/docview/3079855193/abstract/ https://pubmed.ncbi.nlm.nih.gov/PMC11301192 http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322024000100287&lng=en&tlng=en |
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