A comparison of the efficacy of azithromycin and clarithromycin in oral therapy of experimental airborne Legionnaires' disease

• Published in: Journal of antimicrobial chemotherapy Vol. 31 Suppl E; p. 171
• Main Authors: Fitzgeorge, R B, Lever, S, Baskerville, A
• Format: Journal Article
• Language: English
• Published: England 01.06.1993
• Subjects: Administration, Inhalation; Administration, Oral; Aerosols; Animals; Azithromycin; Clarithromycin - pharmacology; Disease Models, Animal; Erythromycin - analogs & derivatives; Erythromycin - pharmacology; Female; Guinea Pigs; Legionella pneumophila; Legionnaires' Disease - drug therapy; Legionnaires' Disease - microbiology; Legionnaires' Disease - pathology; Lung - microbiology; Lung - pathology

The activities of two new macrolides, azithromycin and clarithromycin, were compared in an aerosol-infected guinea-pig model of legionnaires' disease. The results of this study indicate that a low oral dose of azithromycin (3.6 mg/kg) administered once daily gives 100% survival in Legionella pn...