Opposite changes in cannabinoid CB1 and CB2 receptor expression in human gliomas
Gliomas are the most important group of malignant primary brain tumors and one of the most aggressive forms of cancer. During the last years, several studies have demonstrated that cannabinoids induce apoptosis of glioma cells and inhibit angiogenesis of gliomas in vivo. As the effects of cannabinoi...
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| Published in | Neurochemistry international Vol. 56; no. 6-7; pp. 829 - 833 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
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Elsevier
01.05.2010
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| Abstract | Gliomas are the most important group of malignant primary brain tumors and one of the most aggressive forms of cancer. During the last years, several studies have demonstrated that cannabinoids induce apoptosis of glioma cells and inhibit angiogenesis of gliomas in vivo. As the effects of cannabinoids rely on CB(1) and CB(2) receptors activation, the aim of the present study was to investigate both receptors protein expression in cellular membrane homogenates of human glial tumors using specific antibodies raised against these proteins. Additionally, we studied the functionality of the cannabinoid receptors in glioblastomas by using WIN 55,212-2 stimulated [(35)S]GTPgammaS binding. Western blot analysis showed that CB(1) receptor immunoreactivity was significantly lower in glioblastoma multiforme (-43%, n=10; p<0.05) than in normal post-mortem brain tissue (n=16). No significant differences were found for astrocytoma (n=6) and meningioma (n=8) samples. Conversely, CB(2) receptor immunoreactivity was significantly greater in membranes of glioblastoma multiforme (765%, n=9; p<0.05) and astrocytoma (471%, n=4; p<0.05) than in control brain tissue (n=10). Finally, the maximal stimulation of [(35)S]GTPgammaS binding by WIN 55,212-2 was significantly lower in glioblastomas (134+/-4%) than in control membranes (183+/-2%; p<0.05). The basal [(35)S]GTPgammaS binding and the EC(50) values were not significantly different between both groups. The present results demonstrate opposite changes in CB(1) and CB(2) receptor protein expression in human gliomas. These changes may be of interest for further research about the therapeutic effects of cannabinoids in glial tumors. |
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| AbstractList | Gliomas are the most important group of malignant primary brain tumors and one of the most aggressive forms of cancer. During the last years, several studies have demonstrated that cannabinoids induce apoptosis of glioma cells and inhibit angiogenesis of gliomas in vivo. As the effects of cannabinoids rely on CB(1) and CB(2) receptors activation, the aim of the present study was to investigate both receptors protein expression in cellular membrane homogenates of human glial tumors using specific antibodies raised against these proteins. Additionally, we studied the functionality of the cannabinoid receptors in glioblastomas by using WIN 55,212-2 stimulated [(35)S]GTPgammaS binding. Western blot analysis showed that CB(1) receptor immunoreactivity was significantly lower in glioblastoma multiforme (-43%, n=10; p<0.05) than in normal post-mortem brain tissue (n=16). No significant differences were found for astrocytoma (n=6) and meningioma (n=8) samples. Conversely, CB(2) receptor immunoreactivity was significantly greater in membranes of glioblastoma multiforme (765%, n=9; p<0.05) and astrocytoma (471%, n=4; p<0.05) than in control brain tissue (n=10). Finally, the maximal stimulation of [(35)S]GTPgammaS binding by WIN 55,212-2 was significantly lower in glioblastomas (134+/-4%) than in control membranes (183+/-2%; p<0.05). The basal [(35)S]GTPgammaS binding and the EC(50) values were not significantly different between both groups. The present results demonstrate opposite changes in CB(1) and CB(2) receptor protein expression in human gliomas. These changes may be of interest for further research about the therapeutic effects of cannabinoids in glial tumors. |
| Author | SALLES, Joan MEANA, J. Javier GARIBI, Jesús M HOSTALOT, Cristina CALLADO, Luis F LOPEZ DE JESUS, Maider |
| Author_xml | – sequence: 1 givenname: Maider surname: LOPEZ DE JESUS fullname: LOPEZ DE JESUS, Maider organization: Department of Pharmacology, University of the Basque Country, 48940 Leioa, Bizkaia, Spain – sequence: 2 givenname: Cristina surname: HOSTALOT fullname: HOSTALOT, Cristina organization: Department of Pharmacology, University of the Basque Country, 48940 Leioa, Bizkaia, Spain – sequence: 3 givenname: Jesús M surname: GARIBI fullname: GARIBI, Jesús M organization: Department of Surgery, University of the Basque Country, 48940 Leioa, Bizkaia, Spain – sequence: 4 givenname: Joan surname: SALLES fullname: SALLES, Joan organization: Department of Pharmacology, University of the Basque Country, 48940 Leioa, Bizkaia, Spain – sequence: 5 givenname: J. Javier surname: MEANA fullname: MEANA, J. Javier organization: Department of Pharmacology, University of the Basque Country, 48940 Leioa, Bizkaia, Spain – sequence: 6 givenname: Luis F surname: CALLADO fullname: CALLADO, Luis F organization: Department of Pharmacology, University of the Basque Country, 48940 Leioa, Bizkaia, Spain |
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| Keywords | Human CB1 cannabinoid receptor Glial cell Cannabinoids Neuroglia Central nervous system Human brain Cannabinoid Encephalon Glial tumors |
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| Title | Opposite changes in cannabinoid CB1 and CB2 receptor expression in human gliomas |
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